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Q: Medical ( Answered,   1 Comment )
Question  
Subject: Medical
Category: Health > Conditions and Diseases
Asked by: mom16-ga
List Price: $2.50
Posted: 15 Apr 2005 05:49 PDT
Expires: 15 May 2005 05:49 PDT
Question ID: 509598
I have muscle pain in upper parts of both legs. I was precribed
lipitor and took it for awhile and this is when it started. I have
stopped taking it and wonder if they will get better? What can I do to
help it get better?
Answer  
Subject: Re: Medical
Answered By: hummer-ga on 15 Apr 2005 09:58 PDT
 
Hi mom16,

Ofcourse nothing can substitute for your physician's advice, but I can
give you some general information in order to help you be better
informed during your next doctor's visit. I've cut and pasted some
relevant parts but please click on the links for complete details.
Myopathy (muscle damage) is a known side effect of the cholesterol
lowering drugs (statins) and Lipitor (atorvastatin) is one of them.
The good news is that once the drug is discontinued, your symptoms
should disappear within weeks (or sometimes longer). If your symptoms
are particularly troublesome, you could ask your doctor about the
possibility of taking corticosteroids. While you are waiting for the
symptoms to subside, be kind to your muscles and do moderate, not
strenuous exercise.

MYOSITIS
Myositis is the medical term for muscle inflammation. In myositis,
inflammation damages the fibers of a muscle. This causes muscles to be
weak by interfering with the ability of the muscles to contract.
Myositis also can cause muscle aches and muscle tenderness."
DRUG-INDUCED
Drug-induced myositis - In drug-induced myositis, muscle inflammation
occurs as a side effect of a medication or a combination of medicines.
Although this is rare, the most common medications that can cause
myositis are the cholesterol-lowering drugs called statins - including
atorvastatin (Lipitor)..."
SYMPTOMS
Drug-induced myositis - Symptoms include muscle soreness, pain and
weakness, beginning after a person starts taking a new drug or a
combination of drugs."
DURATION
Drug-induced myositis - Symptoms usually disappear once you stop
taking the drug. However, this can take weeks or months."
TREATMENT
Drug-induced myositis - Your doctor will discontinue any medication
that may be causing myositis. Medications called corticosteroids may
help you to recover faster."
PROGNOSIS
Drug-induced myositis - The prognosis is very good. In most cases,
symptoms subside when the drug is stopped."
http://www.intelihealth.com/IH/ihtPrint/WSIHW000/9071/25398/200800.html?d=dmtHealthAZ&hide=t&k=basePrint

The Scripps Mercy Clinical Research Center is a voluntary group of
physicians, pharmacists and nurses who have collaborated in the
IMPOSTER evaluation of patients with muscle complaints on statin
therapy.
"In patients with atypical symptoms we generally search for
alternative explanations for their symptoms.  In patients with typical
symptoms we stop statin therapy for 2 weeks.  If their symptoms
resolve and they were receiving statins for primary prevention we
recommend alternate lipid lowering therapies."
The therapeutic options which we offer to patients with hyperlipidemia
who can not take statins include:
1. Low Fat Diet
2. Mediterranean Diet
3. Exercise
4. Resins and Cholesterol Absorbing Drugs:
5. Non-statin Cholesterol Lowering Drugs
6. Plant Stanols and Sterols (2 grams a day at lunch)
7.  Policosinol 
8.  Red yeast rice 
"We inform the patients that none of these options will be as powerful
as a statin in lowering cholesterol.  However, we reassure them that
many therapies such as the Mediterranean Diet and Niacin have benefits
in preventing atherosclerosis and its complications beyond those which
can be explained by lowering cholesterol alone. We are all eager to
see our patients cholesterol levels fall as a good sign that a therapy
is working but some of these therapies work well despite producing
less cholesterol reduction than statins."
http://www.impostertrial.com/physician.htm

Cholesterol, Other Lipids, and Lipoproteins
"The primary safety concern with statins has involved an uncommon
condition called myopathy, which can cause muscle damage and in some
cases, muscle and joint pain."
http://adam.about.com/reports/000023_7.htm

Additional Links of Interest:

Statin Adverse Effects
http://medicine.ucsd.edu/SES/adverse_effects.htm

Drug-Induced Myopathy
"The clinical symptoms of muscle weakness and myalgia may take several
weeks or months to resolve after laboratory parameters such as muscle
enzymes return to baseline."
http://www.uspharmacist.com/oldformat.asp?url=newlook/files/Feat/myopathy.cfm&pub_id=8&article_id=444

I was glad to find this for you. If you have any questions, please
post a clarification request *before* closing/rating my answer and
I'll be happy to reply.

Thank you,
hummer

Google Search Terms Used:

statin myopathy symptoms disappear
statins myopathy symptoms
Comments  
Subject: Re: Medical
From: jack_of_few_trades-ga on 15 Apr 2005 06:43 PDT
 
You might want to have your spine checked out.  I have 2 friends who
have/had upper leg pain that is caused by spinal problems... 1 slipped
disc and the other is just an unalligned spine.  A chiropractor can
help alot with an unalligned spine for a relatively small amount of
money (mine is $30 per visit and I went 2ce a week for a month at
first until my back was more stabalized, now I go once a month for
maintenance.)

The slipped disc on the other hand will require more than the
chiropractor can do in most cases.

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