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Subject:
What is a "blind breaker"?
Category: Health > Medicine Asked by: centure7-ga List Price: $4.00 |
Posted:
27 Apr 2005 12:48 PDT
Expires: 30 Apr 2005 12:09 PDT Question ID: 515012 |
I saw the following text in a job description for a pharmaceutical company: "Issue blind breakers and dose assignment envelopes for blinded studies that are not run by an Interactive Voice Response System." What are "blind breakers"? |
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There is no answer at this time. |
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Subject:
Re: What is a "blind breaker"?
From: pinkfreud-ga on 27 Apr 2005 14:08 PDT |
In the pharmaceutical industry, "breaking the blind" refers to the process of revealing the name of the specific drug (or placebo, as the case may be) that has been given to a participant in a double-blind study or clinical trial. I have not encountered the term "blind breaker," but I would guess that it may have to do with the paperwork that is associated with breaking the blind in a drug trial. http://www.childrens-mercy.org/stats/weblog2004/blind.asp |
Subject:
Re: What is a "blind breaker"?
From: myoarin-ga on 27 Apr 2005 15:18 PDT |
I found the term once in this context. The site talked about double-blind studies and the difficulties assuring that they were unimpeachable. From the quotation in the question: "Issue blind breakers and dose assignment envelopes for blinded studies", I could imagine that when the "dose assignment envelopes" are prepared for distribution to the MDs in the study, there must also be prepared a control record of what is actually in the envelopes (test drug & dosage or placebo). This list could serve as a "blind breaker", but if the drug being tested suddenly gave rise to serious side-effects, it would be tedious and time-consuming to go back to this record. SO, I expect that along with the "dose assignment envelopes" the MDs are also given a sealed envelope with the true info (maybe like PINs are sent), so that when the alarm on side-effects goes off, each doctor can immediately use this "blind breaker" to know if his patient has been taking the drug and also could be subject to the side effect. I hope it is that, that the studies anticipate this scenario. Of course, at the end of the study, the sealed envelopes must be returned with each MDs' findings to prove that the double-blind was upheld. |
Subject:
Re: What is a "blind breaker"?
From: centure7-ga on 29 Apr 2005 08:52 PDT |
Thank you both. Given the context, I'm now fairly certain that the blind breaker must be the paperwork showing which patients recieved the placebo and which ones are recieving the treatment. |
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