Specific to recombinant monoclonal antibody against integrins
employing the alpha-4 chain (VLA-4)

Why target integrins rather than their molecular ligands, ICAMs? And
what are the cell types that this antibody target?

Interesting question;

Here is some background, integrin4alpha is found as part of a
heterodimer with b1 on Natural Killer, B, T, Eosinophils, Endothelial,
Muscle, and Fibroblasts - it plays a role in T cell transedothetlial
migration.


The ligrands for a4b1 -- include, a4b1, a4b7, fibronectin, vcam-1, MAdCAM1 and TSP1.