At the beginning of my answer stands a little surprise: The place you
refer to as Yzeran does still exist. Its Jewish shtetl has been wiped
out in World War II, but not the town itself. I will explain the
results of my research step by step:
I was aware of the fact that the eastern borders of Poland shifted
about 200 kilometers westward after World War II; so I knew that if
Yzeran was indeed located in the southeast part of what was pre-war
Poland, that region (East Galicia) would now belong to the Ukraine. I
kept that in mind during my research.
I also took into account that place names and their spellings are
anything but consistent or enduring in those regions of Eastern
Europe. One and the same place could have various Polish, Ukrainian,
Yiddish and German names, all of them with numerous spelling variants.
So I also had to pay attention to possible alternate names and
Knowing that, I searched for references with the spelling you
provided, "Yzeran". I did not find much, but there was one important
hint: I found two articles about American comic book artist Joe
Kubert, who recalls the name of the place where he was born before his
family emigrated in 1926 as "Yzeran, on the south-eastern end of
Poland."  He also used his birth place as the setting for his
graphic novel "Yossel".
This seemed to be the only explicit reference to Yzeran. And the
connection with the family name "Kubert" was my only reliable clue so
I consulted the ShtetlSeeker database of Eastern European towns 
with former Jewish communities. Among the results were no places
exactly matching with the name Yzeran, but in the list of resulst
there was one town ca. 237 miles west-south-west of Kiev whose name
was given in three different spelling variants: Jezierna / Yezerna /
Ozernaya. This town is located in the Ukraine today, but prior to
WWII, it would have been the south-eastern part of Poland. And two of
the possible spellings were similar to Yzeran.
I decided to do more research on this place. Through the Falling Rain
Global Gazetteer  I found out that this Ukrainian town still
exists, and that there are even more possible spellings: Ozernaya,
Ozernyany, Ozerna, Jezierna, Yezerna, Ozėrnaya, Ozernyani.
Knowing this, I now had to find out if the Ukrainian town known as
Ozernaya today is identical with the Yzeran where Joe Kubert was born.
Was Ozernaya home to a family of the name Kubert?
A full search of the entire JewishGen website content  led to one
clue that I was correct: I found a list of surnames of Holocaust
victims from Ozernaya , and the name "Kubert" showed up in that
list. It did not appear on other similar lists, so I assumed that the
name was typical for Ozernaya only and would only rarely occur
My assumption was confirmed when I searched for the surame "Kubert" in
the family records database of Jewish Records Indexing - Poland .
Numerous individuals of that name were found, and almost all entries
referred to the town "Jezierzany". And Jezierzany is, as I found out,
the Polish name for Ozernaya/Ozeryany.
The town has its own website in the JewishGen database, providing some
This is an extensive article  on the history of the town and its
Besides, the Yiddish/Jewish name of Ozeryany was Oziran or Ozieran. It
is obvious that this is actually a variant of "Yzeran".
Since Ozeryany still exists today, you don't even need a pre-war map
to locate it. This MapQuest map shows you its location; use the
zoom-out feature to get a better overview:
In addition, I have prepared this extract of a pre-war map of Poland
for you. The black arrow points to Jezierzany/Ozeryany; the red arrow
points to the city of Tarnopol, which can be easily located on a
modern-day map of the Ukraine (Ukrainian name: Ternopil), so you get
an impression on where the town is:
I hope that this information is useful for you!
 The Jewish Week: The Comic Book As Resistance
 Silver Bullet Comic Books: Joe Kubert - From Shtetl to Grand Master
 JBooks.com: Yossel - Introduction
 Forward: Veteran Artist Evokes Jewish Strength - Overtly
 JewishGen ShtetlSeeker: Town Search
 Falling Rain Global Gazetteer: Ozernaya, Ukraine
 JewishGen: Search the JewishGen website
 JewishGen: Surnames of Jezierzany's Holocaust Victims
 Jewish Records Indexing - Poland: Search Database
 JewishGen ShtetLinks: Jezierzany - Ozeryany, Ukraine
 JewishGen: "Jezierzany" - Encyclopedia of Jewish Communities in
Poland, Volume II (Ozeryany, Ukraine)