I started poking around and found the answer to my question immediately.
Good Call! From what I am able to unearth, this is not uncommon, and
it's from his DHT levels getting too high, just as suspected..
Please send your friend to his medical Doctor ASAP! There are several
options, but the choice should be between your friend and his Doctor,
and possibly his wife.
The Safety of Testosterone Supplementation
-Physician Conference Call-
Jeffry S. Life, M.D., Ph.D.
Cenegenics Medical Institute
Las Vegas, Nevada
April 14, 2004
..."There are several alleged potential risks to testosterone
supplementation including elevation of hemoglobin and hematocrit1,2,
coronary artery disease, abnormal lipid profiles, increase in severity
of sleep apnea, decrease in testicular size or atrophy, decline in
sperm count (rare), fluid retention (usually transient), acne (rare),
hepatotoxicity (rare except with oral forms), prostatic hypertrophy,
and prostate cancer.....Testicular atrophy is associated with direct
testosterone replacement only and occurs in 10 to 12% of treated
individuals. Recovery takes place over 8-12 weeks after stopping
injections. hCG supplementation prevents testicular atrophy..." [much
more at the link]
Effects of testosterone supplementation in the aging male.
..."Another side effect of testosterone supplementation is testicular
shutdown. The body senses all of the excess testosterone in your
system and decides to stop producing its own. This causes your
testicles to shrink and your sperm count to decrease significantly.
The use of clomiphine citrate (more commonly known as clomid) can
prevent this from happening. Clomid stimulates your body to keep
producing its own testosterone. That way, testicular shutdown never
comes about. Even though testicular shutdown is completely reversible
once steroid use has ceased, it is a good idea to prevent it from ever
happening. Once you stop using steroids, your body will start
producing its own testosterone again. But this can take up to a month
to happen. During that month, you will have significantly reduced
amounts of testosterone in you system. Thus, you will most likely lose
much of your gains once you stop using testosterone. To prevent
testicular shutdown, I suggest using clomiphine citrate (AKA Clomid).
I recommend 25mg of clomid per day per 500mg of testosterone you use.
Since clomid most often comes in 50mg tablets, that would equate to
one tablet every other day. If you are using 1000mg of testosterone,
that equates to 1 tablet a day. Clomid has been shown extremely safe
in many laboratory tests and medical research..."
Question #4 - Is Testosterone replacement therapy safe?
..."Natural Testosterone can be used safely in large doses by men who
are deficient. Normal healthy doses present no health risks to men.
Only if the levels of Testosterone metabolites, such as DHT or E2,
rise above ideal physiologic range, can problems occur. These include
baldness, prostate enlargement, shrinking of testicles, increased
acne, and loss of sex drive with moodiness and emotionality..."
..."Side-effects from testosterone replacement therapy are rare, but
can include the shutting down of natural testosterone production,
shrinking of the testicles, hair loss, increased sexual desire, and
aggression. In women, male characteristics, such as the deepening of
the voice, and facial hair may develop..."
Scroll very near the bottom to: The side effects of testosterone that
have been noted can be summed up as follows:
..."Testicular atrophy, otherwise known as shrinkage of the testicles,
can also happen, and this is because when you are supplementing the
testosterone in your body with testosterone your body may stop
producing the hormone itself. To return the testes to their normal
size, you could take human chorionic gonadotropin, or HCG, which can
be administered at the end of, or during a cycle to kick-start the
production of testosterone and return your testes to a normal size.
Some people also take breaks when applying testosterone to themselves
so that the body is given a chance to resume natural production.
Apparently, the shrinkage of testes happens more with injections,
rather than gel or patches..."
Re: One solution to shrinking testicles
Another forum posting worth reading.
If I can be of further assistance in regards to testosterone
supplements and testicular atrophy, please ask for a clarification
before rating this answer and I'll be happy to assist.
Search terms used at Google:
testosterone topical testicles smaller OR shrinking
testosterone "testicular atrophy"
hCG supplement testicular atrophy
testosterone DHT testicles