Could someone please help me find unbiased published results from
medical journals etc. on the completed CAFE study. It stands for
Comparison of Atypicals in First Episode Psychosis. It was sponsored
by Astrazenca. There was a small mention at the 8th World Congress in
Psychiatry recently. I am looking for more info on the adverse effects
and the suicides.

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Clarification of Question by mjh1234-ga on 05 Aug 2005 05:14 PDT

The study results are just now starting to come out. By unbiased, I am
hoping to find more information on the adverse effects, such as
suicide, that were only mentioned by one source at the 8th world
congress of psychiatry. I realize completely, Astrazenca, the sponsor,
will try to hide that information, and all information that might be
negative to their product. It was a clinical study headed by the
University of North carolina and conducted around the country at 26
sites.It compared seroquel, zyprexa, risperdal in people with a first
episode of schizophrenia.CAFE, comparison of atypicals in first
episode psychosis.

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Request for Question Clarification by pafalafa-ga on 05 Aug 2005 05:32 PDT

Have you seen this article already?


http://64.233.161.104/search?q=cache:DSjQ0dY_PpoJ:www.medscape.com/viewarticle/507638+%22Comparison+of+Atypicals+in+First+Episode+Psychosis&hl=en


Let me know if this is useful.

pafalafa-ga

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Clarification of Question by mjh1234-ga on 05 Aug 2005 06:29 PDT

The medscape article I have already seen. It is the only article with
the reference to suicide from the study thank-you.

In searching PubMed for the title you presented, I found three trials,
one of which is in Japanese.  The citations follow.  I'm not sure what
you mean by "unbiased" published results, though --- depending on your
philosophic stance, one might consider all studies to be biased.  If
you just want the raw data (and are mathematically inclined), you
might appeal to the author of a given study.  Otherwise you might
check to see if the publishing journal is a well-respected,
peer-reviewed journal, and look at the methodology of the study
itself...

Comparative effect of atypical and conventional antipsychotic drugs on
neurocognition in first-episode psychosis: a randomized, double-blind
trial of olanzapine versus low doses of haloperidol.
Am J Psychiatry. 2004 Jun;161(6):985-95. 
PMID: 15169686 [PubMed - indexed for MEDLINE]

[A clinical study of emergent anxiety in neuroleptic-naive,
first-episode schizophrenia patients following treatment with
risperidone]
Seishin Shinkeigaku Zasshi. 2003;105(5):643-58. Japanese. 
PMID: 12875232 [PubMed - indexed for MEDLINE]

Atypical and conventional antipsychotic drugs in treatment-naive
first-episode schizophrenia: a 52-week randomized trial of clozapine
vs chlorpromazine.
Neuropsychopharmacology. 2003 May;28(5):995-1003. Epub 2003 Mar 26. 
PMID: 12700715 [PubMed - indexed for MEDLINE]