Google Answers Logo
View Question
 
Q: Microbiology ( Answered 3 out of 5 stars,   3 Comments )
Question  
Subject: Microbiology
Category: Miscellaneous
Asked by: mashhour-ga
List Price: $5.00
Posted: 19 Aug 2002 01:49 PDT
Expires: 18 Sep 2002 01:49 PDT
Question ID: 56131
CHoose the single most appropriate from those listed below and place
it in the left or right the question.
(A) CH2 region of molecule
(B) CH3 region of molecule
(D) CH4 region of molecule
(E) None of these

1- The Clq binding site of IgG
2- The Clq binding of IgM
3- The Clq binding of IgD
4- The Clq binding of IgE
5- Neutrophil, monocyte, platelet, and lymphocyte binding site IgG
6- Lymphocyte binding site of IgM
7- J chain binding site of IgG
8- Neutrophil binding site if IgM
9- Antigenic combining site of IgG

Choose the single most appropriate answer from those listed below and
place it.
(A) Allergy capable of transient passive transfer from one person to
anothe by serum.
(B) Allergy capable of passive transfer by mean of cell only.
(C) Both
(D) neither

1- Systemic anaphylaxis
2- Tuberculin sensitivity
3- Food Allergy
4- Contact dermatitis
5- Poison Ivy
Answer  
Subject: Re: Microbiology
Answered By: nealc-ga on 20 Aug 2002 08:41 PDT
Rated:3 out of 5 stars
 
After conferring with the resident immunologist in my department we
came up with the following answers.

(A) CH2 region of molecule 
(B) CH3 region of molecule 
(D) CH4 region of molecule 
(E) None of these 
 
1- The Clq binding site of IgG (A- CH2)
2- The Clq binding of IgM (B- CH3)
3- The Clq binding of IgD (E- none of these)
4- The Clq binding of IgE (E- none of these)
5- Neutrophil, monocyte, platelet, and 
lymphocyte binding site IgG (A- CH2)
6- Lymphocyte binding site of IgM (If this is monomeric IgM with the
transmembrane portion of IgM linked to the surface of a naïve B cell
then the answer would be D- CH4, However, if you what the portion of
IgM bound to an Fc receptor on a lymphocyte then the answer would be
B- CH3)
7- J chain binding site of IgG (E- none of these)
8- Neutrophil binding site of IgM (E- none of these)
9- Antigenic combining site of IgG (E- none of these)
 
Choose the single most appropriate answer from those listed below and
place it.
(A) Allergy capable of transient passive transfer from one person to
another by serum.
(B) Allergy capable of passive transfer by means of cells only. 
(C) Both 
(D) Neither 
 
1- Systemic anaphylaxis (A)- requires allergen, IgE, and mast cells.
If the recipient has sufficient mast cells then passively transferred
IgE and allergen will cause mast cell degranulation.
2- Tuberculin sensitivity (B)
3- Food Allergy (A)- same reason as 1 above.
4- Contact dermatitis (If type IV hypersensitivity then it is (B) if
type I hypersensitivity then (A))
5- Poison Ivy (B)

A text that might be of help for other questions you may have would be
Immunology, 6th edition, by Roitt, Brostoff, and Male, Mosby press,
2001.
Hope that helps.
Nealc-ga
mashhour-ga rated this answer:3 out of 5 stars
In the first Questions, I think the number 1,5 and 6 are wrong

Comments  
Subject: Re: Microbiology
From: nealc-ga on 22 Aug 2002 07:40 PDT
 
Actually the answer to question 1 of the first question set is
correct. See the following websites:
http://www.xs4all.nl/~ednieuw/IgGsubclasses/subkl24.htm

http://medweb.bham.ac.uk/immunityinfection/research/RoyJefferis/croatia/croatia.html

The second website references journal articles that demonstrated the
glycosylation of the CH2 site is important for Fc receptor binding to
IgG as well as C1q.
Subject: Re: Microbiology
From: nealc-ga on 22 Aug 2002 07:49 PDT
 
With respect to C1q binding to IgM the Roitt textbook I referred to in
our answer states on page 59 that,"IgM is very efficient at complement
activation as it contains potentially 10 C1q binding sites in its CH3
domains." Furthermore, the same page of Roitt states that,"the six
heads of C1q each contain a binding site for a domain in IgG (CH2)."
Subject: Re: Microbiology
From: mashhour-ga on 22 Aug 2002 09:49 PDT
 
Sorry you are right not # one of the first Question, i think # 2,5,
and 6 of the first Question are wrong

Important Disclaimer: Answers and comments provided on Google Answers are general information, and are not intended to substitute for informed professional medical, psychiatric, psychological, tax, legal, investment, accounting, or other professional advice. Google does not endorse, and expressly disclaims liability for any product, manufacturer, distributor, service or service provider mentioned or any opinion expressed in answers or comments. Please read carefully the Google Answers Terms of Service.

If you feel that you have found inappropriate content, please let us know by emailing us at answers-support@google.com with the question ID listed above. Thank you.
Search Google Answers for
Google Answers  


Google Home - Answers FAQ - Terms of Service - Privacy Policy