I am following the career of Cynthia Kenyon. My motivation is that she
seems to be the person closest to figuring out how to extend lifespan
in mammals, including hominids like me. I would like a listing of her
most recent writings (later than '04) and citings (later than '04),
preferably written to audiences with an average IQ greater than room
temperature. The winner will have found "breakthrough" in an article.
Thanks, all.

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Request for Question Clarification by pafalafa-ga on 05 Sep 2005 17:49 PDT

Can you clarify what you mean by 'citings'.

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Request for Question Clarification by knowledge_seeker-ga on 06 Sep 2005 04:55 PDT

Hi Jimbaen

I have found a listing of a couple hundred articles authored or
co-authored by Cynthia Kenyon (not all are the correct Cynthia
however. Must vet the list.). These are all from scientific journals.
However, at first glance (and I haven't taken the time to look
closely) very few by your Cynthia are as current as 2004. I only found
1 in the first 25 articles.

It is here:

Regulation of C. elegans Longevity by Specific Gustatory and Olfactory Neurons
http://seroudelab.biology.queensu.ca/pdf/alcedo.pdf 

Is that the kind of thing you are looking for? If so, I'd be happy to
go through the list and give you the ones that meet your criteria.

Also, to repeat what Pafalafa-ga asked, what do you mean by citings.
Do you want a list of articles that cite her?

Let me know how you'd like me to proceed.

Thanks, 

-K~

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Request for Question Clarification by knowledge_seeker-ga on 06 Sep 2005 04:58 PDT

One thing I should clarify: You will not be able to read most of these
articles online. Without subscriptions to the various journals you
will only have access to the the abstracts and in some cases just the
bibliography.

-K~

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Clarification of Question by jimbaen-ga on 06 Sep 2005 07:41 PDT

What I mean by 'citings': Well, a citation of an article written by
Cynthaa K. or other person dealing with DAF-12 expression. I'd very
much like to see articles regarding life extension in non-mousy
mammals, especially by disabling DAF-12.
I'd LOVE to see an article explaining why Cynthia keeps getting
younger ever since she extended lifespan in C. elegans. :)(I'm 62 and
I want to fix that. The irony  is just excruciating: to miss out by
ten or so years after three billion years of evolution is just too
painful. :)

Hi Jimbaen, 

Wow, what an interesting search!  I?ve read the headlines over the
years, but haven?t followed the actual science. Fascinating!

This is a list of Cynthia Kenyon?s publications linked from her own website:

PUBMED: search results kenyon+c
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?dispmax=25&db=PubMed&cmd=Search&term=kenyon%2Bc&doptcmdl=DocSum%20


However her search term [Kenyon+c] results in many articles by other
scientist with similar names (especially a rather prolific CJ Kenyon
in Scotland). I?ve cleaned up the search results (see my search
strategy at the end of this answer) and presented the most recent
articles below.

I believe I have found everything that she?s published in the last 2-3
years. I took the liberty of including some 2003 articles that seemed
relevant.

It doesn?t appear that Dr. Kenyon is working on anything other than
the trusty nematode, c. elegans. At least one article makes
comparisons with fruit flies, but I don?t see anything more advanced
than that in her literature. Looks to me like it?s going to be some
years before we all get to live twice as long as we do now.


=====================
ARTICLES 
=====================

New Genes Tied to Endocrine, Metabolic, and Dietary Regulation of
Lifespan from a Caenorhabditis elegans Genomic RNAi Screen
Malene Hansen, Ao-Lin Hsu, Andrew Dillin, and Cynthia Kenyon
PLoS Genet. 2005 July; 1(1): e17.
http://www.pubmedcentral.gov/articlerender.fcgi?tool=pubmed&pubmedid=16103914

---------------------------------

Identification of Genes That Regulate a Left-Right Asymmetric Neuronal
Migration in Caenorhabditis elegans
QueeLim Ch'ng, Lisa Williams, Yung S. Lie Mary Syma, Jennifer Whangbo
and Cynthia Kenyon
Genetics, Vol. 164, 1355-1367, August 2003
http://www.genetics.org/cgi/content/full/164/4/1355

CITED BY 1 ARTICLE
GOOGLE SCHOLAR SEARCH RESULTS
http://scholar.google.com/scholar?hl=en&lr=&q=link:xCI24atR4EQJ:scholar.google.com/


--------------------------------

Comparing genomic expression patterns across species identifies shared
transcriptional profile in aging.  Nature Genetics February 2004
CS Chin, YN Jan, C Kenyon, CI Bargmann, H Li 
http://mobydick.ucsf.edu/~haoli/nat_gen_comp_func_genomics_2004.pdf

CITED BY 26 ARTICLES: GOOGLE SCHOLAR SEARCH RESULTS
http://scholar.google.com/scholar?hl=en&lr=&q=link:FUQjAw7ABqwJ:scholar.google.com/

---------------------

Neuron. 2004 Jan 8;41(1):1-3.
Regulation of C. elegans Longevity by Specific Gustatory and Olfactory Neurons
Alcedo J, Kenyon C.
http://seroudelab.biology.queensu.ca/pdf/alcedo.pdf
 
CITED BY 66 ARTICLES: GOOGLE SCHOLAR SEARCH RESULTS
http://scholar.google.com/scholar?hl=en&lr=&q=link:5whXZbvWmR4J:scholar.google.com/


===================
ABSTRACT ONLY
===================

The roles of two C. elegans HOX co-factor orthologs in cell migration
and vulva development
Lucie Yang*, Mary Sym{dagger} and Cynthia Kenyon
Development 132, 1413-1428 (2005)
Published by The Company of Biologists 2005
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15750187&query_hl=6

------------------------------

Cell. 2003 Nov 14;115(4):489-502.
Tissue-specific activities of C. elegans DAF-16 in the regulation of lifespan.
Libina N, Berman JR, Kenyon C.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=14622602&query_hl=12

CITED BY 20 ARTICLES: GOOGLE SCHOLAR SEARCH RESULTS
http://scholar.google.com/scholar?hl=en&lr=&q=link:kTzQy40jXIMJ:scholar.google.com/

-----------------------------

The plasticity of aging: insights from long-lived mutants.
Kenyon C.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15734678&query_hl=6

CITED BY 3 ARTICLES: GOOGLE SCHOLAR SEARCH RESULTS
http://scholar.google.com/scholar?hl=en&lr=&q=link:njdXeALbaWkJ:scholar.google.com/

-----------------------------

Genes that act downstream of DAF-16 to influence the lifespan of
Caenorhabditis elegans. Nature. 2003 Jul 17;424(6946):277-83. Epub
2003 Jun 29.
Murphy CT, McCarroll SA, Bargmann CI, Fraser A, Kamath RS, Ahringer J,
Li H, Kenyon C.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12845331&query_hl=12

CITED BY 108 ARTICLES: GOOGLE SCHOLAR SEARCH RESULTS
http://scholar.google.com/scholar?hl=en&lr=&q=link:ugy5skWwTT8J:scholar.google.com/

-------------------------------

Regulation of aging and age-related disease by DAF-16 and heat-shock
factor. Science. 2003 May 16;300(5622):1142-5.
Hsu AL, Murphy CT, Kenyon C.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12750521&query_hl=12

CITED BY 49 ARTICLES: GOOGLE SCHOLAR SEARCH RESULTS
http://scholar.google.com/scholar?hl=en&lr=&q=link:xQOWOTXQtwAJ:scholar.google.com/


=====================
BIBLIOGRAPHY ONLY
=====================


Comment in: Science. 2004 Aug 27;305(5688):1238-9.
Healthy animals with extreme longevity.
Arantes-Oliveira N, Berman JR, Kenyon C.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=14576426&query_hl=12


CITED BY 18 ARTICLES: GOOGLE SCHOLAR SEARCH RESULTS
http://scholar.google.com/scholar?hl=en&lr=&q=link:hW6DXcSKZZEJ:scholar.google.com/

------------------------------------------


As for Cynthia?s personal anti-aging strategy, take a look at the
woman! She never stops smiling!

GOOGLE IMAGE SEARCH: CYNTHIA KENYON
http://images.google.com/images?svnum=10&hl=en&lr=&q=%22Cynthia+Kenyon&btnG=Search

This is a woman who clearly loves what she does, is passionate for
research, and has enthusiastic hope for the future. If that doesn?t
keep a person young, nothing will.

Thanks for a great question. I had fun answering it and learned a lot.
 If anything?s not clear, let me know and I?ll be happy to clarify for
you.

-K~

SEARCH STRATEGY:

PUBMED
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed

Searched: Kenyon C[au] 94143 

.. and sorted by date.  I added the zip code for UCSF in order to weed
out the other researchers with similar names.

GOOGLE SCHOLAR
http://scholar.google.com/

Cynthia Kenyon 2004
Cynthia Kenyon 2005

In Google Scholar, once you have an article, a link beneath the
article on the search results page takes you directly to all articles
citing that one.

GOOGLE IMAGES:  
http://images.google.com/imghp?hl=en

?Cynthia Kenyon?

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Clarification of Answer by knowledge_seeker-ga on 08 Sep 2005 03:50 PDT

Hi again, 

I just noticed, in checking over my links, that the number of
citations in the Google Scholar search results is ever-changing. They
are going up (as one might expect), so my numbers are no longer
correct.

-K~