Hello Sasijo,
Most drug allergies manifest symptoms rather quickly, from 10-15
minutes to a few hours. Others, such as serum sickness can take up to
a week to develop. Generally speaking, the faster allergic symptoms
appear, the more dangerous they can be.
"Symptoms occur rapidly on re-administration of the drug and subside
within 3-5 days of discontinuance of the drug. The drugs most commonly
associated with allergic reactions are penicillins, sulphonamides,
sulphonylurea hypoglycaemics, ACE inhibitors, thiazide diuretics.
The clinical manifestations may be immediate or delayed.
Anaphylactic symptoms usually follow rapidly after exposure to the
drug. Some reactions are slower in onset and may occur between 30 min
? 2 hours. "
http://www.allergysa.org/drugallergy.htm
"Reactions to drugs or antibiotics can take many forms and about 25%
of all drug reactions may represent a true immunologic event.
Immediate or IgE mediated reactions are some of the most serious
events and these can be diagnosed by skin testing with the implicated
drug."
http://www.breathingeasy.com/pages/allergy.html
"Reactions range from irritating or mild side effects such as nausea
and vomiting, to allergic reactions, including life-threatening
anaphylaxis. Some drug reactions are idiosyncratic (unusual effects of
the medication). For example, aspirin can cause nonallergic hives (no
antibodies formed), or it may trigger asthma. Only a small proportion
of these reactions are allergic in nature. Many individuals may
confuse an uncomfortable but not serious side effect of a medicine,
such as nausea, with a true drug allergy, which can be
life-threatening.
True drug allergies occur when there is an allergic reaction to a
medication. This is caused by hypersensitivity of the immune system,
leading to an incorrect response against a substance that is harmless
in most people. The body becomes sensitized (the immune system is
triggered) by the first exposure to the medication. The second or
subsequent exposure causes an immune response, including the
production of antibodies and release of histamine.
"Most drug allergies cause minor skin rashes and hives. However, other
symptoms occasionally develop and life-threatening acute allergic
reaction involving the whole body (anaphylaxis) can occur. Serum
sickness is a delayed type of drug allergy that occurs a week or more
after exposure to a medication or vaccine."
http://www.nlm.nih.gov/medlineplus/ency/article/000819.htm
"The most common symptoms are itching, redness, swelling of the skin,
welts, and a runny nose. Symptoms of a drug allergy can occur fairly
quickly, possibly within minutes of taking the first dose, or they can
begin several days after taking the drug. About half of all allergic
reactions occur one week after starting the drug. Most symptoms should
disappear in 3 to 5 days after stopping the drug. Ask you doctor if
you can treat the symptoms mentioned above with an allergy medication,
such as an antihistamine (e.g., Benadryl®, Chlortrimeton®).
You also should be aware of a rare, but potentially life-threatening
reaction to a drug allergy. Analyphylaxis, a severe reaction that
usually occurs immediately after taking a drug, can cause difficulty
breathing, increased heart rate, and decreased blood pressure. If you
think that are developing symptoms of a drug allergy, stop taking the
drug. There is an increased chance of anaphylaxis with repeated
exposure to the drug (the more doses you take). If you suspect
anaphylaxis, seek medical help immediately. An anaphylactic reaction
can be fatal."
http://www.umm.edu/careguides/allergy/allergy_drugallergies.html
Hope this helps!
Regards, Crabcakes
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