subject: molecular mechanism of aldosterone-stimulated
amiloride-sensitive  sodium current in kidney

need a report form discussion on these two question (about 2500 words)

Q1: general terms the mechanisms by which the activity of an ion
channel, such as ENaC could be upregulated. consider transcriptional
regulation, reotein trafficking and direct action on the channel.

Q2: the experiment focuse on the early response to aldosterone.
investigate, via the literature, the transcriptional effects taking
place in the late phase of aldosterone treatment.