MULTIPLE CHOICE: Please help me to answer the following question and
Choose most appropriate. Answers for # 1-4


[A] IgA [B] IgD [C] IgE [D] IgG [E] IgM [F] S-IgA 

1. Half-life in human blood of approximately 21 days

2. Immunoglobulin class most frequently acting as rheumatoid factor in
rheumatoid arthritis.

3. Selective immunoglobulin deficiency most frequently involves which
class?

4. Heavy chain (Franklin's) disease usually involves the heavy chains
of which antibody class?


5. Type II hypersensitivity reactions may involve which of the
following?

[A] IgG  [C] Complement  [E] A and C only 

[B] IgM  [D] A,B and C  [F] A and B only 


6. Which of these characteristically does not cross placental barrier
in humans?

[A] IgG1  [B] IgG2  [C] IgG3  [D] IgG4 



7. IgA protease is produced by several bacterial pathogens against:

[A] IgA1  [B] IgA2  [C] Both  [D] Neither 



8. Which of the following possess a J-chain ?

[A] IgM  [B] IgD  [C] Both  [D] Neither 



9. Which of the following is not produced by plasma cells ?

[A] Mu chains  [D] J -chains

[B] Kappa chains  [E] Secretory piece

[C] Lambda chains 

10. IgA protease is produce by all of the following EXCEPT:

[A] Hemophilus influenzae  [D] St. mutans

[B] St. pneumoniae   [E] Neisseria gonorrhoeae

[C] St. pyogenes   [F] Neisseria meningitides 



11. The serum of a five day-old infant is analyzed for quantitation of
immunoglobulins. The lab reports the following values: IgG = 800 mg/dl
IgA = 1 mg/dl; IgM = 20 mg/dl. Which of the following statements is
most correct?

[A] The IgM is of fetal origin

[B] The IgM is both of fetal and maternal origin.

[C] The IgG is of fetal origin.

[D] The immunoglobulin in the serum is all of fetal origin.

[E] The immunoglobulin in the serum of this infant is all of maternal
origin.


12. Which is the region of complement fixation?

[A] Light chain   [D] Hypervariable region

[B] Heavy chain   [E] Fab portion

[C] Kappa or lambda chain

1) IgG has a half-life of approximately 20 days (or 21)
http://antibodies.homestead.com/CLASSES.html

2)  Rheumatoid factor is usually IgM antibodies against IgG
antibodies.
http://www.researchd.com/rdikits/rdiigmkt.htm

3)  IgA is the most frequently involved in selective immunoglobulin
deficiency
http://www.ahealthyme.com/topic/topic100587006

4)  Franklin's disease is related to IgG heavy chain
http://merck.praxis.md/bpm/bpmtables_print.asp?page=BPM01HE11

5)  IgG, IgM, and complement are all involved in type II
hypersensitivity reactions:
http://stingray.bio.cmu.edu/~web/imm/lec15.pdf

6)  IgG2 does not cross the placenta as well as the others:
http://ntri.tamuk.edu/immunology/classes-ab.html

7)  the proteases are produced against IgA1
http://www.sv.cc.yamaguchi-u.ac.jp/~plasma/msg/nextpage/Ig.html

8)  Only IgA possesses a J-chain
http://www.sv.cc.yamaguchi-u.ac.jp/~plasma/msg/nextpage/Ig.html

9)  The secretory piece is produced in mucosal cells, not in plasma
cells
http://www.sv.cc.yamaguchi-u.ac.jp/~plasma/msg/nextpage/Ig.html

10)  The only bacteria in this list which does not express IgA
protease is
s. pyogenes

http://microvet.arizona.edu/Courses/MIC419/SystemModules/microbeevasion.html
http://www.forp.usp.br/bdj/t0572.html
http://216.239.51.100/search?q=cache:fvp0OECxfLUC:cbms.st-and.ac.uk/academics/coote/Teaching/MedMicro/RespInf1-typatyppneum/tsld007.htm+iga+protease+s+pneumoniae&hl=en&ie=UTF-8

11)  IgG is the only Ig that crosses the placenta, therefore, the IgM
is fetal
http://www.microimm.mcgill.ca/coursenotes/513-PREG-Note.pdf

12)  The Fc region of the antibody fixes complement - this is entirely
composed of heavy chains

http://www.cpes.sussex.ac.uk/users/jms/bcenv/lec15/15.pdf