I'd like a list of the top 25 selling cancer therapeutics (generic
names listed with approximate yearly market sales -- for 2004 or 2005
worldwide or US) AND the chemical name and structure of the drugs. The
structure can be pasted in as a picture or provided as a link. For
example one item on the list might be:

#     Generic name    Sales         Chemical Name    Structure 

17.  Temozolomide    $215M (2005, US) 
3,4-dihydro-3-methyl-4-oxoimidazo[5,1-d]-as-tetrazine-8-carboxamide   
structure: http://en.wikipedia.org/wiki/Image:Temozolomide.png


There is no need to include structures or chemical names for
antibodies or peptides.

The important part of the question is the chemical name & structure. 
The sales need not be exactly right, although I would like to get a
general idea of where each drug ranks and I'm only interested in the
top 25 right now (although if you get more this would be great!).

---

Request for Question Clarification by pafalafa-ga on 19 Apr 2006 09:31 PDT

sko123-ga,

There does not appear to be a readily-availble, free source of
information that lists the top 25 cancer drugs.

I think I can probably tease out such a list from numerous discrete
sources, but that alone would take a substantial (i.e. $200-worth)
amount of effort.

Let me suggest two possible ways to move forward on your question:

1.  If you could supply us with a list of the drugs of interest to
you, we could look into the generic name and structure information for
you.

2.  If you don't have such a list, perhaps this current question
should be pared down to simiply developing a list of the Top 25 cancer
drugs.  You could then ask a separate question seeking names/structure
for each of the drugs.


Let me know your thoughts on this.


pafalafa-ga

---

Clarification of Question by sko123-ga on 19 Apr 2006 13:03 PDT

Pafalafa-ga,
For $200 you can find the trade names and sales of the top 50 cancer
drugs and I'll worry about the chemical names and structures later.
Thanks

Hello sko123-ga,

This is a very tough search because the sales ranking information
about cancer drugs and therapeutics is closely guarded and generally
only available from very expensive databases. Commercial Insight:
Generic Cancer Market is a December 2005 Datamonitor report that has
most of the information you?re looking for but it costs $15,200. Many
other market research reports are available on the cancer therapeutics
and drugs industry for similarly high prices.

http://www.datamonitor.com/~d4da7f1734fa4c87892619f8dcbecd74~/Products/Free/Report/DMHC2115/020DMHC2115.htm
Commercial Insight: Generic Cancer Market ? 
New Legislation and a Wave of Patent Expiries to Transform the Market ? 


After extensive searching I was able to identify a report of the Top
200 Drugs for 2004 by U.S. Sales. This report gives a listing of Rank,
Product, Company and US Sales in $Billions. I reviewed this list and
identified 24 cancer drugs. This was very time consuming because I had
to click on the product name of each drug I didn?t recognize to see if
it was a cancer drug. Fortunately, the link in this table for each
drug provides the generic names that you asked for.

http://www.drugs.com/top200.html
Top 200 Drugs for 2004 by U.S. Sales.
Source: NDCHealth, NDC PHAST, 3/2005


Next, I used databases available from the FDA and the National Library
of Medicine to find the additional technical information you wanted. I
was able to locate the molecular formula and systematic name for each
of the 24 drugs I had identified. In addition, the ChemIDplus database
had the diagram of the structure of the drug for about half of the
drugs on my list.

http://chem.sis.nlm.nih.gov/chemidplus/
National Library of Medicine (NLM)
Specialized Information Services (SIS) National Library of Medicine (NLM) 
ChemIDplus Advanced Search
Provides chemical structure, property, and toxicity searching.

http://www.fda.gov/cder/cancer/druglistframe.htm
http://www.accessdata.fda.gov/scripts/cder/onctools/druglist.cfm
U.S. Food and Drug Administration
Center for Drug Evaluation and Research
Listing of Approved Oncology Drugs with Approved Indications


In the course of my search I found some additional resources that were
helpful in providing information about current market trends and I was
able to identify some additional drugs that you might want to know
about even without having the information about their sales figures.

http://www.leaddiscovery.co.uk/reports/Cytotoxics%20-%20Third-Generation%20Cytotoxics%20To%20Offset%20Taxol%92s%20Generic%20Woes.html
Cytotoxics - Third-Generation Cytotoxics To Offset Taxol?s Generic Woes

http://www.leaddiscovery.co.uk/reports/Commercial_Insight_Antihormonal_Therapies.html
Commercial Insight: Antihormonal Therapies
Aromatase Inhibitors Reinvigorate a Mature Market

http://www.leaddiscovery.co.uk/reports/pharmaceutical_reports/The_Cancer_Market_Outlook_to_2010.html
The Cancer Market Outlook to 2010

http://www.piribo.com/publications/diseases_conditions/cancer/dat277.html
Cancer Market Top 20 Drugs
Supportive Care Grows the Cancer Market


I consolidated all of the information I gathered into an Excel
spreadsheet showing the following items:
 -- Cancer Drug Rank
 -- NDC Rank
 -- Product Name
 -- Company
 -- U.S. Sales $Billions
 -- Generic Name
 -- Systematic Name
 -- Molecular Formula
 -- Structure

You can download the table from this address. 

http://download.yousendit.com/39139F0F5C2A7814

Be sure to do it as soon as possible since it will be available only
for a few days.


The information you want is tough to find. I wish you well for
continuing your research.

~ czh ~