"In the U.S. alone, 50 million Pap tests are performed each year, and
they discover close to 1.2 million cases of low-grade dysplasia
(cervical intraepithelial neoplasia [CIN]1), 300,000 cases of
high-grade dysplasia (CIN2/3) and 10,000 cases of cervical cancer.?
The Oncologist, Vol. 10, No. 7, 528-538, August 2005;
Cervical Intraepithelial Neoplasia (CIN)
?CIN, also called cervical dysplasia, is characterized by the presence
of abnormal cells that often precede cervical cancer. These abnormal
cells are usually detected in women through regular Pap smear
screening. More than 1.2 million women are diagnosed with low-grade
cervical dysplasia and another 200,000 to 300,000 are diagnosed with
high-grade cervical dysplasia each year in the U.S.?
Stressgen Biotechnologies Corporation
?Cervical intraepithelial neoplasia (CIN) refers to the pre-invasive
pathological intermediate of cervical cancer. The abnormalities
observed on a Pap smear or tissue biopsy of the cervix represent
alterations in the degree of differentiation of cervical epithelial
cells. In the United States alone, approximately 3.5 million women
have abnormal Pap smear tests each year. Approximately 1.2 million of
these women have a squamous intraepithelial lesion, of which 200,000
to 300,000 are high-grade.?
?The American College of Obstetricians and Gynecologists estimates
that 250,000 to 1 million new cases of cervical intraepithelial
neoplasia (CIN) are diagnosed in
the United States annually.?
?Approximately 50 million Pap smears are taken yearly in the United
States, and 5 to 10% of these smears are reported as having low-grade
cytologic abnormalities, involving an estimated 2.5 million women.?
?An estimated 12,900 new cervical cancers and 4,400 cervical cancer
deaths will occur in the United States in 2001. An additional
1,250,000 women will be diagnosed yearly with changes referred to as
squamous intraepithelial lesions (SIL) or cervical intraepithelial
neoplasia (CIN). These changes form a continuum divided into low- or
high-grade SIL or CIN 1, 2, and 3 that reflects increasingly abnormal
changes of the affected epithelium. These lesions can persist,
regress, or progress to an invasive malignancy. High-grade SIL (CIN
2-3) is more likely to persist or progress and less often regresses
spontaneously, while low-grade SIL (CIN 1) often regresses without
Association of Online Cancer Resources
Search terms used:
million patients "cervical intraepithelial neoplasia"
"Cervical Intraepithelial Neoplasia" million 100000..500000"
million CIN "cervical intraepithelial neoplasia"
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