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Q: Insulin pump research ( Answered 4 out of 5 stars,   2 Comments )
Question  
Subject: Insulin pump research
Category: Health > Medicine
Asked by: yoda451-ga
List Price: $50.00
Posted: 27 Apr 2006 14:21 PDT
Expires: 27 May 2006 14:21 PDT
Question ID: 723464
How long were insulin pumps in clinical trials?

Request for Question Clarification by czh-ga on 27 Apr 2006 14:32 PDT
Do you have any particular insulin pump in mind? This technology has
been around for a long time.

http://www.caregiver.com/channels/rural/articles/outlook_for_diabetes.htm

I look forward to your clarification.

~ czh ~

Clarification of Question by yoda451-ga on 27 Apr 2006 18:21 PDT
I'm interestd in the first insulin pump (should have been introduced
by MedTronic in 1983).  If you are thinking of a different
introduction date, let me know.

Request for Question Clarification by bobbie7-ga on 27 Apr 2006 20:39 PDT
Hello Yoda451,

Insulin pumps were being developed in the early 1960s. In 1983 MiniMed
brought the first pump to market.

Please take a look at the following material and let me know if this
is the sort of information you?re looking for.

Thanks,
Bobbie7

 
?Dr. Arnold Kadish of Los Angeles, California, devised the first
insulin pump in the early 1960s. It was worn on the back and was
roughly the size of a Marine backpack (Figure 1). Rigorous clinical
testing for CSII began in the late 1970s,[3-5] and by the early 1980s,
CSII was being considered as a possible alternative form of insulin
delivery for patients with type 1 diabetes.[6]

"The AutoSyringe model, also known as the "Big Blue Brick," was the
first commercial pump.[7] Upon its 1978 introduction, excitement
spread throughout the medical community, and several companies began
to promote the development of insulin pumps. However, many of these
pumps lacked the controls necessary to ensure safe insulin delivery.
They were not very user-friendly, and some models even required the
use of a screwdriver for dosage adjustment.[8] In addition, the idea
of wearing a large, heavy pump and being hooked to a machine
understandably met with resistance among patients.[7] In the early
1980s, pump therapy was reserved only for the most difficult-to-manage
cases, and the results were often unsatisfactory.[8] By the late
1980s, insulin pump therapy was still used in only a minority of
patients.?

Medscape
http://www.medscape.com/viewprogram/2622_pnt

1978-1983

Continuous subcutaneous insulin infusion: an approach to achieving
normoglycaemia. Br Med J. 1978
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=340000&dopt=Abstract

Reduction to normal of plasma glucose in juvenile diabetes by
subcutaneous administration of insulin with a portable infusion pump.
N Engl J Med. 1979
http://content.nejm.org/cgi/content/abstract/300/11/573

Continuous subcutaneous insulin infusion in the treatment of diabetes
mellitus. Diabetes Care. 1980
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=6993143&dopt=Abstract

Clinical use of the insulin infusion pump in 100 patients with type I
diabetes. N Engl J Med. 1982
http://content.nejm.org/cgi/content/abstract/307/9/513


1983 - First Pump To Market
MiniMed 502.
MiniMed 502A insulin pump 
http://www.minimed.com/about/history.html
Answer  
Subject: Re: Insulin pump research
Answered By: bobbie7-ga on 02 May 2006 17:36 PDT
Rated:4 out of 5 stars
 
Hello again Yoda451,

Thank you for accepting my findings as the answer to your question. I
am reposting the information below to make it official.

Insulin pumps were being developed in the early 1960s. In 1983 MiniMed
brought the first pump to market.

Best regards, 
Bobbie7

 
?Dr. Arnold Kadish of Los Angeles, California, devised the first
insulin pump in the early 1960s. It was worn on the back and was
roughly the size of a Marine backpack (Figure 1). Rigorous clinical
testing for CSII began in the late 1970s,[3-5] and by the early 1980s,
CSII was being considered as a possible alternative form of insulin
delivery for patients with type 1 diabetes.[6]

"The AutoSyringe model, also known as the "Big Blue Brick," was the
first commercial pump.[7] Upon its 1978 introduction, excitement
spread throughout the medical community, and several companies began
to promote the development of insulin pumps. However, many of these
pumps lacked the controls necessary to ensure safe insulin delivery.
They were not very user-friendly, and some models even required the
use of a screwdriver for dosage adjustment.[8] In addition, the idea
of wearing a large, heavy pump and being hooked to a machine
understandably met with resistance among patients.[7] In the early
1980s, pump therapy was reserved only for the most difficult-to-manage
cases, and the results were often unsatisfactory.[8] By the late
1980s, insulin pump therapy was still used in only a minority of
patients.?

Medscape
http://www.medscape.com/viewprogram/2622_pnt

1978-1983

Continuous subcutaneous insulin infusion: an approach to achieving
normoglycaemia. Br Med J. 1978
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=340000&dopt=Abstract

Reduction to normal of plasma glucose in juvenile diabetes by
subcutaneous administration of insulin with a portable infusion pump.
N Engl J Med. 1979
http://content.nejm.org/cgi/content/abstract/300/11/573

Continuous subcutaneous insulin infusion in the treatment of diabetes
mellitus. Diabetes Care. 1980
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=6993143&dopt=Abstract

Clinical use of the insulin infusion pump in 100 patients with type I
diabetes. N Engl J Med. 1982
http://content.nejm.org/cgi/content/abstract/307/9/513


1983 - First Pump To Market
MiniMed 502.
MiniMed 502A insulin pump 
http://www.minimed.com/about/history.html
yoda451-ga rated this answer:4 out of 5 stars

Comments  
Subject: Re: Insulin pump research
From: czh-ga on 29 Apr 2006 12:13 PDT
 
This is an interesting slide show on the history of pumps.

http://www.picturetrail.com/gallery/view?p=999&gid=201986&uid=103405
The Evolution of Pumps
Subject: Re: Insulin pump research
From: yoda451-ga on 02 May 2006 17:30 PDT
 
bobbie7 - yep, that's what I was looking for.  Put it in the answer
section - thanks!

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