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Q: Need a basic math computer program to perform the curve-fitting for biology. ( Answered ,   5 Comments )
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 Subject: Need a basic math computer program to perform the curve-fitting for biology. Category: Computers > Algorithms Asked by: los111-ga List Price: \$200.00 Posted: 04 May 2006 07:21 PDT Expires: 03 Jun 2006 07:21 PDT Question ID: 725394
 ```Need a small computer program to perform the curve-fitting for biology. I am a biology graduate student, and I can?t write a computer program by myself. I need a small program (any language) to perform to find a best-fit Gaussian curve from a small set of numbers (X,Y) by least-square-fit method. I can do this easily by off-the-shelf statistic program, Sigma Plot Table Curve, but doing so one by one is way too slow. I need to do in bulk (thousands of them) quickly. For example, I have a set of number (X,Y), (1, 10), (2, 25), (3, 45), (4, 30), (5, 12). All I need is one number (Xmax), at which Y shows maximum value. For example, in this example, it?s Xmax = 3.099395. Doing this task manually takes only 1 minutes (it requires about 15 clicks), but it becomes a big problem when I have to obtain five thousands X max from five thousands set of numbers. I don?t care what program language you use (C, C++, Java etc), as long as it runs on Windows OS or Mac OS (Windows is better). All numbers are stored in Microsoft Excel, but I can paste it in any program. It doesn?t have to be super-fast. As long as I can do this task (say, obtain 5000 Xmax) within 1hour, that?s fine. Alternatively, if you know the trick to do this task using an existing program (Sigma Stat /Plot, Excel), that?s fine with me too. (But it should not require a very expensive computer program which I can?t afford.) You can keep a copy right of a written program, but you have to agree with me that I may distribute the program for free in an academic circle (non-profit). You also have to give me both original code and compiled program. The Xmax value must be accurate. It has to use a simple least-square fit. I don't need "robust" non-linear fitting.``` Clarification of Question by los111-ga on 04 May 2006 07:24 PDT ```For clarification, I don't need to see curve-fitting itself. As long as I get Xmax number, that's all I need.``` Request for Question Clarification by hummer-ga on 04 May 2006 12:03 PDT ```Hi los111, Have you looked at SigmaPlot and its skeleton macro Systat? It might help you get started but unfortunately, its \$499.00 (Academic). SYSTAT 11 http://www.systat.com/products/SigmaPlot/?sec=1085 DOWNLOAD SYSTAT® TRIAL VERSION: "The following product demo is a "Full Featured" working copy of the latest 32-bit version of the software and not just a "slide show" demo. As scientists ourselves, we know the importance of being able to evaluate software to make sure that it fits your needs, and we are committed to providing demonstration software that gives you an excellent overview of the products. If you have suggestions for improvements or comments about our demos, please let us know. This demo will expire after 30 days, and you may share it with colleagues who may have an interest in our applications." http://www.systat.com/downloads/?sec=d001 SYSTAT 10 GRAD PACK \$139.95 http://www.academicsuperstore.com/market/market.html?category_id=244388 Regards, hummer``` Request for Question Clarification by hummer-ga on 04 May 2006 12:15 PDT ```AUTOMATED CURVE FITTING IN TABLECURVE 2D® : http://www.systat.com/products/TableCurve2D/?sec=1010 hummer```
 Subject: Re: Need a basic math computer program to perform the curve-fitting for biology. Answered By: leapinglizard-ga on 05 May 2006 09:42 PDT Rated:
 ```Dear los111, Since you're already using TableCurve, you can take advantage of its built-in production facility to calculate the Xmax value for many data sets at once. First, your data must be arranged in an Excel spreadsheet in columns, with X and Y values in alternating rows. In other words, X values for the first data set should be in column A, and Y values for the first data set in column B; then X values for the second data set in column C, with Y values for the second data set in column D; and so forth. If the X values are identical for every data set, you can list them just once in column A, then put the Y values for each data set in columns B, C, and so on. If your spreadsheet cannot be easily rearranged in one of these formats, show me the layout in a Clarification Request -- either by posting a fragment of the spreadsheet or by linking to the entire file -- and I'll see if I can give you a Python script to automatically rearrange the data. I have uploaded three data sets of my own to the following location, to assist you in following my walkthrough of the procedure. Sample Data http://plg.uwaterloo.ca/~mlaszlo/answers/sample_data.xls Once your spreadsheet is ready, start TableCurve and select "Import..." from the File menu. A window will appear with a list of the columns in your spreadsheet. Select column A and click on "X Values", then select column B and click on "Y Values". Click "OK" to continue. In the next window, you can choose names for the data set and variables, or just click "OK" to accept the defaults and continue. Now generate your fit curve as usual. I used only the plain Gaussian curve among the peak equations, with 500 maximum iterations and 6 significant digits. Once you've configured your curve, click "Fit" and then, in the next window, click the "Graph Start" button. Even if you perform additional configuration, you must go to the Graph Start window -- you can get there from the main window by selecting the first entry under the Review menu -- in order to generate the report. Once you're happy with the curve and you're at the Graph Start window, look at the lowermost row of buttons at the left side of the window. The rightmost of these buttons, which says "Production Facility" when the cursor hovers over it, is the one you want. Click it, then select the "Excel 95/97/200" radio button, which is second from the top. Click the "Select" button immediately below it to choose the Excel file you imported earlier, then select "First worksheet", assuming that your data is indeed on the top layer of the spreadsheet. Otherwise, select the appropriate layer. Then select either the "XY Pairs" or "Single X" radio button, depending on which format you employed in your spreadsheet. I used XY Pairs in mine because the X values are different for each data set. In the "Output" pane, look at the checkboxes listed under "Write Report" and make sure only the one labeled "Numeric Summary" is checked. Uncheck all the others. You can then deselect the "Write Report" checkbox. Now check the "Write Processed Data to Excel File" checkbox and click the "Select" button below it to choose a name and location for the output file. For "Sets Per Sheet", select 1, and for "XLS Format", select 95. You should avoid the 97/2000 output format because it is flawed. Once you've clicked OK, TableCurve processes all the data sets and writes the results to the specified output file, which you can open in Excel once the processing is done. You will see that the numerical summary for each data set is written to its own layer. The Xmax value will be in cell B5 of each layer. This is because the maximum value of a Gaussian curve is also its mean value, and the mean is given by parameter c. In the spreadsheet, this is the third of the parameter values in the second column, and should therefore fall in cell B5 if you faithfully followed every step. The output resulting from my own data is at the following location. Sample Summaries http://plg.uwaterloo.ca/~mlaszlo/answers/sample_summaries.xls If you run into any difficulties with the procedure I outline above, please advise me through a Clarification Request so that I can make sure your needs are fully met. Please do not rate this answer until you have succeeded in carrying out the entire procedure and arrived at the results you desire. Regards, leapinglizard Search strategy: mean maximum gaussian distribution ://www.google.com/search?hs=sMN&hl=en&lr=&client=firefox-a&rls=org.mozilla%3Aen-US%3Aofficial&q=mean+maximum+gaussian+distribution&btnG=Search``` Request for Answer Clarification by los111-ga on 29 May 2006 09:36 PDT ```Dear leapinglizard-ga, No, that's not the answer I want. I clearly said that I didn't have a problem calculating it for one for few sets of numbers. I do not understand why you explain the process I know step by step. My problem is how to do 5000 sets in a first speed. I have 5000 Excel sheets and just opening 5000 takes more than a few hours.``` Request for Answer Clarification by los111-ga on 29 May 2006 10:03 PDT ```Dear leapinglizard-ga, Please read my question. I CLEARLY said this: "I can do this easily by off-the-shelf statistic program, Sigma Plot Table Curve, but doing so one by one is way too slow. I need to do in bulk (thousands of them) quickly." I have no problem doing it. I know how to use Sigma Plot or Table Curve. And you aswered the process I already know in a detail. But you never answered to my question, how to do it quickly if you have 5000 sets of numbers. And remember, my first request is if you can write a problem for this task. You never answred to that request either.``` Clarification of Answer by leapinglizard-ga on 29 May 2006 10:28 PDT ```All of your data sets can be processed in one shot if they are present in the same Excel file, since the Production Facility explicitly provides for multiple data sets. I can easily write you a Python script that unifies the separate Excel files into a single file. All I need to know is the format of the individual files. If you could describe this format, or, better yet, link to a few of these files so that I can examine them myself, I will provide the unification script in short order. leapinglizard``` Request for Answer Clarification by los111-ga on 30 May 2006 12:28 PDT ```Thank you for your quick reply. If you can write a Python prgram, that may solve the problem (but I need the original code too.) All my excel sheet has X numbers in the first column, Y numbers in the second column. Some has only 10 rows, some has 30-50 rows. I assume that doing 50 sheets or 500 or 5000 sheets requires a same procedure. All I need it the automated program. I need a final result in one excel sheet, showing the list of Xmax, like (sheet 1, Xmax = 3.4), (Sheet 2, X max = 4.56)....(Sheet 500, X max = 4.33) etc. I will try to upload Excel file in somewhere so that you can see an example. I will add more comments later to clarify the situation.``` Request for Answer Clarification by los111-ga on 30 May 2006 13:13 PDT ```Another problem is that your version ot Table Curve can be older than mine. I use the newest version v5.01.02, you can get 30days trial version (full functional) for free. I pasted the screenshot of my table curve here. http://img144.imageshack.us/img144/7885/tablecurve6so.gif http://img330.imageshack.us/img330/7752/table24pz.gif I can't find "Production facility" you mentioned. I think what you meant was "Automated Processing"? I tried it, but it didn't work either. OK button disappeared, and I can't click it.``` Request for Answer Clarification by los111-ga on 30 May 2006 13:58 PDT ```I think I figured out the "Production Facility" part. In a new version of TableCurve, it's called "Automated Processing". But there is a problem again. You told me that I find the Xmax value in B5 cell in each sheet, but then I have to collect the number in B5 cells, by cut and paste from 5000 sheets, which takes probably 12 hours. This problem cannot be solved unless you write a simple python program (or any program) which can collect value in B5 cells from all sheets, and arrange only Xmax value in a sheet. By the way, I filed the complain to Google Answer yesterday before I saw your clarification, because your first answer didn't solve the problem at all. But as long as you can solve this simple problem by two python programs (one combine all sheets into one Excel sheet, another collects B5 from all sheets into one sheets), I will withdraw it. In addition, if you have a capability to write this type of program, I am willing to do more business with you. I am not going to be unreasonalbe, if 5000 sheets are too many, I can do ten times for 500 sheets.``` Request for Answer Clarification by los111-ga on 30 May 2006 17:12 PDT ```Again, just wanted to clarify this. Auto-processing function of Table Curve itself doesn't solve the problem, because I have already known the "Batch Process Excel" function and "Regression Wizard" function in Sigma Plot, which allowed me to open all Excel files. But batch process function still creates 5000 excel files, and I have to go through all sheets, which takes probably 15 hours. I need all Xmax value in one sheet. That's what I need, and I think you can solve it easily by Python program. Thank you.``` Clarification of Answer by leapinglizard-ga on 30 May 2006 18:06 PDT ```Let me get this straight. Are you saying that you can already run a batch job on all 5000 data sets? So the only remaining problem is to extract the Xmax value from each result file? And Xmax is always in cell B5 in each of the 5000 result files? If the answer to all three of these questions is yes, then I can indeed write a Python script to assemble the Xmax values into a single file. I presume a CSV (comma-separated value) file would be fine? Excel can open CSV files without any trouble. I imagine it would be best to have the Xmax values in column A and the corresponding file names in column B. leapinglizard``` Request for Answer Clarification by los111-ga on 31 May 2006 08:25 PDT ```Dear leapinglizard-ga, First of all, I think i should apologize to 1 star rating thing. Some other explained the whole situation, and I put this comment to answer his question. When I saw that my order was "CLOSED" while I didn't get my real answer, and I was charged \$200 on 05/05/2006 while I never received any notification in my gmail, and Google didn't have any phone line, and Google Answer customer service never replied to my complain, I felt that it was like a fraud, and that's why I gave a 1 big star, as a way to show my dissatisfaction. But After reading Clarification from this expert, I started to think that this expert himself is doing his best and the poor service is due to Google Answer itself.``` Request for Answer Clarification by los111-ga on 31 May 2006 08:35 PDT ```Let me get this straight. Are you saying that you can already run a batch job on all 5000 data sets? So the only remaining problem is to extract the Xmax value from each result file? And Xmax is always in cell B5 in each of the 5000 result files? >>>>This Batch function of Sigma Plot produces a whole report in the word file, not excel. So, I can't say it's in "B5 cell". CSV is absolutely fine. I imagine it would be best to have the Xmax values in column A and the corresponding file names in column B. >> that is correct. And I need both original code and compiled program. I do not distribute it, you can keep the copy right, but I need the code in case I have to modify something. (I cannot write a program from scratch, but I do have some very basic knowledge of C, UNIX, MS-DOS and I may be able to change something small.)``` Clarification of Answer by leapinglizard-ga on 31 May 2006 09:26 PDT ```It can be tricky to extract data from Word files, but I'll be able to write a script to do it if they are formatted in a consistent fashion. Could you take, say, five of these files from a batch job and upload them to a file hosting service such as streamload.com or badongo.com? This would ensure that I am working with exactly the same file format that you're producing. leapinglizard``` Request for Answer Clarification by los111-ga on 31 May 2006 14:47 PDT ```>>>Clarification of Answer by leapinglizard-ga on 31 May 2006 09:26 PDT It can be tricky to extract data from Word files, but I'll be able to write a script to do it if they are formatted in a consistent fashion. Could you take, say, five of these files from a batch job and upload them to a file hosting service such as streamload.com or badongo.com? This would ensure that I am working with exactly the same file format that you're producing. ------------------------------------------------------ I will upload thing in this evening. But if you can convert all excel files (all in the same directory) into one file by Python (all sheets have X number in column 1, Y number in colum 2), Table Curve can produce the excel file too. I don't care about the order of X max, as long as I know the sheet's file name. Either way is fine to me. I will upload the file and more files and will post it tonight.``` Clarification of Answer by leapinglizard-ga on 31 May 2006 15:21 PDT ```I am willing to implement the other method if necessary, but I want to try this one first because it calls for less code and therefore less debugging, greater maintainability, and so forth. Either way, I'll have some code for you tomorrow. leapinglizard``` Request for Answer Clarification by los111-ga on 31 May 2006 16:35 PDT ```Dear lizard: I just found that the problem with Sigma Plot is that you can "batch-process" to open 5000 excel files and do regression all data from 5000 Excel sheets with a single click, but you cannot batch-process to save all these 5000 files (what a stupid program!) with a single click. It opens up 5000 REPORTs, but you have to save them manually. I asked around in my lab, but it seems that there is no way to get around this. It seems that would be best if you can convert 2 columns in 5000 excels sheet in one excel sheets. I tried Visual Basic Editor for Excel to do that task, but coudn't figure out. So it would be best if you can write a Python for. 1. your program converts 5000 Excels sheets to one Excel sheet. 2. Table Curve calculates Xmax (Gaussian) for all of them and export into 5000 sheets. 3. Collect all B5 cells from 5000 sheets into one excel file. Total sheet numbers may be 5000 or 3499 or 342. If your program can figure it out automatically, it would be great. But if it can't, I can change some parameter as long as there is an instruction. Thank you.``` Clarification of Answer by leapinglizard-ga on 31 May 2006 17:03 PDT ```I understand. I'll proceed to work on scripts to do the Excel file consolidation and data extraction. You'll hear from me tomorrow evening. leapinglizard``` Request for Answer Clarification by los111-ga on 31 May 2006 17:26 PDT ```Thanks. Just to explain the situation, the reason why i want to do this very fast is that I have to do about 1000 calculations of 5000 Excel sheets for over next 2 years. My one experiment produces about 5000 Excel sheets and I have to do it again and again. That's why I have to establish the fast method. Even cutting 1 minute in each process will save a lot of work over years.``` Clarification of Answer by leapinglizard-ga on 31 May 2006 18:06 PDT ```It is perfectly natural to want to automate a procedure like yours. Trust me, the problem will be solved within the next day or two. I have plenty of experience with automated data extraction and conversion, and, furthermore, I aim to restore your confidence in this service and to earn your repeat business. leapinglizard``` Clarification of Answer by leapinglizard-ga on 01 Jun 2006 23:26 PDT ```I apologize for the delay, but I am very tired and I ask you to wait one more day before I give you the solution. I have worked it out over the past few hours, and it remains only to write instructions for you. Instead of writing a Python script to do the file merging, which after some study I concluded would be too hard, I found an Excel macro that will do this work. Once the files are merged into one, with one data set per sheet, you can run the TableCurve batch process and output the results in an RTF document. My script extracts the Xmax values and produces a CSV file. So it's all ready to go. I just need to rest and run some urgent errands tomorrow before I can sit down to do the write-up. leapinglizard``` Request for Answer Clarification by los111-ga on 02 Jun 2006 07:34 PDT ```That's OK. Please take your time. I will ask Google Answer to try to change the star rating to better one. I do not understand why Google doesn't email-notify the user. I myself run a small web service, but that's simply unacceptable. Had they done it, this whole thing went much better for both of us.``` Request for Answer Clarification by los111-ga on 05 Jun 2006 14:06 PDT `Hi, 4 days passed, but no reply. Are you still working on it?` Request for Answer Clarification by los111-ga on 05 Jun 2006 18:36 PDT ```I noticed that this question expired without any answer. I have to file for a refund.``` Clarification of Answer by leapinglizard-ga on 06 Jun 2006 14:17 PDT ```I apologize for the delay in getting back to you. I had a very stressful weekend dealing with personal matters, but I am now back in action and ready to devote my attention to customers. At the end of this message, I enclose the Visual Basic code for an Excel macro that will merge all your separate data spreadsheets into a single workbook, with one data set per sheet. Follow the instructions below to use this macro. 1. Start a new workbook in Excel. 2. Type Alt-F11 to open the macro explorer. 3. Right-click on VBAProject (Book1) in the upper-left pane. 4. Select Insert -> Module and paste in the code. 5. In the code, change the value of dataFolderName to the absolute pathname of your data directory. Now close the macro explorer. 6. Type Alt-F8 to open Macros, select "merge", and click on Run. 7. Save the resulting workbook before making any changes. 8. Make sure the front sheet, named Index, is active. Now select File -> Save As... and, in the "Save as type:" menu at bottom, choose CSV (Comma delimited). Choose an appropriate name for the file. 9. When you click Save, a warning will appear. Click OK to save the active sheet. Another warning will appear about incompatible features. Click Yes to leave out these features. 10. After saving the index as a CSV file, close this file and choose not to save changes. 11. Now open the workbook that resulted from running the macro. 12. Delete the index sheet by selecting Edit -> Delete Sheet. Save the workbook. You can now run a batch job in TableCurve, as outlined in my original answer. You should choose to output the results as an RTF (Rich Text Format) file. In my next message, I will give you Python code to extract the X_max values from this RTF file and merge them with the CSV index. leapinglizard Option Explicit Sub merge() Application.ScreenUpdating = False Dim xlsFileNames() As String Dim i As Integer Dim fileName As String Dim dataFolderName As String Dim newSheet As Worksheet Dim rowIndex As Long Dim tempBook As Workbook dataFolderName = "C:\Documents and Settings\x\My Documents\data" If Right(dataFolderName, 1) <> "\" Then dataFolderName = dataFolderName & "\" End If fileName = Dir(dataFolderName & "*.xls") If fileName = "" Then MsgBox "no excel files found" Exit Sub End If Do While fileName <> "" i = i + 1 ReDim Preserve xlsFileNames(1 To i) xlsFileNames(i) = dataFolderName & fileName fileName = Dir() Loop Set newSheet = Workbooks.Add(1).Worksheets(1) newSheet.Name = "Index" rowIndex = 0 For i = LBound(xlsFileNames) To UBound(xlsFileNames) rowIndex = rowIndex + 1 newSheet.Cells(rowIndex, 1).Value = "'" & xlsFileNames(i) Application.StatusBar = "Processing: " & i & " : " & xlsFileNames(i) Application.DisplayAlerts = False Application.EnableEvents = False Set tempBook = Workbooks.Open( _ Filename := xlsFileNames(i), _ ReadOnly := True) tempBook.Worksheets(1).Copy after := _ newSheet.Parent.Worksheets(newSheet.Parent.Worksheets.Count) newSheet.Cells(rowIndex, 2).Value = "'" & ActiveSheet.Name tempBook.Close savechanges := False Application.EnableEvents = True Application.DisplayAlerts = True Next i newSheet.UsedRange.Columns.AutoFit newSheet.Select Application.ScreenUpdating = True Application.StatusBar = False End Sub``` Clarification of Answer by leapinglizard-ga on 06 Jun 2006 14:24 PDT ```Have you submitted the refund request already? If so, I am sure it will be approved. You will get your money back, and the one-star rating will be expunged from my record. If you wish to continue our exchange, please post a new question to my attention. If you have not requested a refund, I will complete the present answer through Clarifications. leapinglizard``` Clarification of Answer by leapinglizard-ga on 06 Jun 2006 19:11 PDT ```It seems a message has gone missing. Did you post a Clarification Request recently? I am anxious to resolve this matter to your satisfaction. leapinglizard```

 Subject: Re: Need a basic math computer program to perform the curve-fitting for biology. From: magnesium-ga on 30 May 2006 17:26 PDT
 ```It strikes me as odd that you are now asking Leaping Lizard to write a program for you, even though you have already given his work a final rating of one star. Why did you assign that rock bottom rating if you intended to seek more assistance from the researcher? This is kind of like slamming the door on a salesman's foot and then asking for a bargain price on the merchandise.```
 Subject: Re: Need a basic math computer program to perform the curve-fitting for biology. From: los111-ga on 30 May 2006 17:49 PDT
 ```Well, your comment is quite odd to me too. You said, "you are now asking Leaping Lizard to write a program for you". Please read my origianl question carefully. The very thing I am asking expert is to write a program! The answer I got from my "expert" is something you can get by using Help function of the TableCurve! I paid \$200 for it, and of course I am not satisfied with the answer. And you accuse me of "you are NOW asking to write a program"? Google advertised that I pay only when you are satisfied with the answer, so I was expecting the better answer from other experts. Then, I found that Google has already charged me \$200 on my credit card on May 5th! I asked Google Answer but there is no reply. Now, the credit card company told me that only way to dispute is that I document all the reasons why I am not satisfied with it, and I HAD TO put 1 star for documentation, otherwise they ask me why I didn't put the star. If you blame me on putting 1 star, you should ask why google charged me on May 5th, and why they don't answer to my email, why they don't even have a customer support phone line.```
 Subject: Re: Need a basic math computer program to perform the curve-fitting for biology. From: los111-ga on 30 May 2006 18:03 PDT
 ```I also have to add this very strange aspect of Google Answer. I made this Google Answer account using Google gmail account. Two accounts (Google Answer and gmail) are linked. Then why didn't GOOGLE send me by email that "You get answer!" notification or something? I thought I didn't get any answer, because I didn't get any email notification. I used other Ask/Answer web service, but they always email you when you get an answer. Any merchant, including Ebay, paypal, Amazon, any forum, credit card company, also gives you an email notification. I will make sure to make a payment to an expert as long as I get a Pythong program from this expert, but this Google service is ridiculous.```
 Subject: Re: Need a basic math computer program to perform the curve-fitting for biology. From: hummer-ga on 31 May 2006 07:32 PDT
 ```Dear los111, Regarding email notifications, GA has always sent them whenever any activity was posted on a question but unfortunately, something went wrong with the service and all notifications have ceased. GA is currently working on the problem and hopes to get it back in working order soon. We all find the lack of notifications very frustrating, but glitches in cyberspace do happen from time to time and I guess we all need to use some patience. Regarding this particular question, leapinglizard-ga posted the answer on 05 May 2006 and that is why your credit card was charged on that date. Just because your question was answered, doesn't mean it is written in stone. The Request For Clarification option is there to communicate with "your" researcher when needed and all researchers are happy to respond promptly to ensure that questioners receive an answer that meets their expectations and you were welcome to use this feature *before you closed and rated the question*. Judging by Leapinglizard's responses so far, it sounds like you would've been more than happy with the answer after a few clarifications. If not, it is possible to ask GA for a refund (after exhausting clarifications), there is no need to involve your credit card company in the refund process. To prematurely rate a question 1 star before giving the researcher a chance to respond, is really not fair. We are only human and given this type of venue (written word only), misunderstandings do happen but they can almost always be worked out through communication. Regarding your statement "...this Google service is ridiculous", on behalf of all GA researchers I would like to say that we're sorry to hear you say that. We take our research seriously and work more hours than I care to admit to provide the best answers that we can. In order to do that, we often need to communicate with the questioner. Don't think of the clarification process as a weakness in the researcher, but rather a strength in the service. Hopefully the email notifications will be up and running again soon! Sincerely, hummer```
 Subject: Re: Need a basic math computer program to perform the curve-fitting for biology. From: los111-ga on 31 May 2006 08:23 PDT
 ```Thank you for your information. It was helpful. I now realized that I should have waited before putting 1 star rating. When I saw that my order was "CLOSED" while I didn't get my real answer, and I was charged \$200 on 05/05/2006 while I never received any notification in my gmail, and Google didn't have any phone line, and Google Answer customer service never replied to my complain, I felt that it was like a fraud, and that's why I gave a 1 big star, as a way to show my dissatisfaction. But After reading Clarification from this expert, I started to think that this expert himself is doing his best and the poor service is due to Google Answer itself.```