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Q: CREATINE bioavailability ( Answered 5 out of 5 stars,   0 Comments )
Subject: CREATINE bioavailability
Category: Health > Fitness and Nutrition
Asked by: saregamapa-ga
List Price: $25.00
Posted: 01 Jul 2006 12:59 PDT
Expires: 31 Jul 2006 12:59 PDT
Question ID: 742637
What is the bioavailability of CREATINE in humans upon oral ingestion
of large doses (5 grams and higher)?  We seek details about its
Subject: Re: CREATINE bioavailability
Answered By: welte-ga on 01 Jul 2006 18:54 PDT
Rated:5 out of 5 stars
Hi saregamapa-ga, and thanks for your question.

The best source for information on this topic is likely the following
review article from the University of Florida and SUNY Buffalo:

Persky AM, Brazeau GA, Hochhaus G.  Pharmacokinetics of the dietary
supplement creatine.
Clin Pharmacokinet. 2003;42(6):557-74.

You can request a reprint of this article from Dr. Persky:

This article provides a detailed description of the synthesis,
metabolism, and pharmacokinetics of creatine.  The authors provide an
overview of the contributors of metabolism of creatine, which you can
view here:

A summary of pharmacokinetic parameters as measured in multiple
studies, including bioavailability, can be found in Table II, which
can be seen here:


The following article is freely available online and discusses the
pharmacology of creatine:

Persky AM, Brazeau GA. Clinical pharmacology of the dietary supplement
creatine monohydrate.
Pharmacol Rev. 2001 Jun;53(2):161-76. Review.

The full text is here:


Here is another article of potential interest:

Absorption of creatine supplied as a drink, in meat or in solid form.
Roger C. Harris, Mary Nevill, D. Beorn Harris, Joanne L. Fallowfield,
Gregory C. Bogdanis and John A. Wise.  Journal of Sports Sciences 20.2
(Feb 2002): p147(5).
You can request a reprint from Dr. Harris:

Here are some additional related articles:


I hope this information is useful.  Please feel free to request
clarification prior to rating.

saregamapa-ga rated this answer:5 out of 5 stars and gave an additional tip of: $5.00

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