L-Carnitine - bioavailability, pharmacokinetics
Category: Health > Fitness and Nutrition
Asked by: saregamapa-ga
List Price: $25.00
04 Jul 2006 21:59 PDT
Expires: 03 Aug 2006 21:59 PDT
Question ID: 743429
What is the bioavailability of L-Carnitine in humans upon oral administrations at low, medium and high dose? We seek details about its pharmacokinetics.
Re: L-Carnitine - bioavailability, pharmacokinetics
Answered By: keystroke-ga on 05 Jul 2006 05:33 PDT
Like most drugs, much of l-carnitine taken orally is lost and not available to the body. The best method for gaining the highest absorption rate is to acquire it through the diet, not theough supplements. Dietary l-carnitine (from the actual diet) maintains an absorption rate of 54-87%, dependent on the dosage, from low (54%) to high (87%), whereas supplementary l-carnitine is passively absorbed and therefore only maintains a bioavailability of 14-18% of the dose taken. Sources: http://www.annalsnyas.org/cgi/content/abstract/1033/1/30 http://www.pdrhealth.com/drug_info/nmdrugprofiles/nutsupdrugs/lca_0060.shtml Search terms: bioavailability + l carnitine Let me know if you need any other assistance or any clarification of this answer. I'd be happy to help! --keystroke-ga
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