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Q: herpes simplex virus 2 and its influence on the progression of AIDS ( No Answer,   2 Comments )
Subject: herpes simplex virus 2 and its influence on the progression of AIDS
Category: Science > Biology
Asked by: tiffany2354-ga
List Price: $5.00
Posted: 15 Jul 2006 19:10 PDT
Expires: 14 Aug 2006 19:10 PDT
Question ID: 746686
Does HSV-2 speed the progression of HIV/AIDS?
There is no answer at this time.

Subject: Re: herpes simplex virus 2 and its influence on the progression of AIDS
From: microman-ga on 17 Jul 2006 16:44 PDT
Although I am not a virologist I would think it would not. My
reasoning for this is because the HSV resides within nerve ganglion
and moves down the nerve to begin an infection. Until this happens,
the virus is hidden from the immune system and therefore the rest of
the body. The HIV virus however transmits itself by infecting white
blood cells (mostly helper T cells) and incorporates its RNA into the
cells DNA. This happens in ?plain site? but the body is hard pressed
in attempt to defeat it because its rapid mutations quickly alter the
virus?s antigenic nature
This being said, both viruses infect different systems of the body,
nervous and immune so I would not see a definite relation.

My apologies if I mentioned information you already knew.
Subject: Re: herpes simplex virus 2 and its influence on the progression of AIDS
From: pforcelli-ga on 19 Jul 2006 20:41 PDT
From the  Journal of Medical Virology,  (Effect of multiple
herpesvirus infections on the progression of HIV disease in a cohort
of HIV seroconverters., Suligoi et al. Feb 2003, 69(2):182-7.) It does
not appear, from this study, that HSV-2 speeds the progression of HIV
to AIDS.  However, a statistical link between HHV-8 and both Kaposi's
sarcoma and subthreshold (<200x10^6 cells/L) CD4+ cell levels was

You should note, that HSV-2 coinfection with HIV does statistically
increase the number of Herpes reactivations, likely due to the immune
supression and stress which are known triggers for HSV reactivation
(Shacker T. Herpes, 2001 Jul; 8(2):46-9.)

It is also worthy of note that it has been reported (Celum, Herpes.
2004 Apr; 11 Suppl. 35-45) that HSV-2 does statistically increase HIV

The picture will become clearer as larger and more accurate clinical
studies are conducted.

So my answer: It may.  It may not.  We don't know yet.

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