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Subject:
herpes simplex virus 2 and its influence on the progression of AIDS
Category: Science > Biology Asked by: tiffany2354-ga List Price: $5.00 |
Posted:
15 Jul 2006 19:10 PDT
Expires: 14 Aug 2006 19:10 PDT Question ID: 746686 |
Does HSV-2 speed the progression of HIV/AIDS? |
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There is no answer at this time. |
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Subject:
Re: herpes simplex virus 2 and its influence on the progression of AIDS
From: microman-ga on 17 Jul 2006 16:44 PDT |
Although I am not a virologist I would think it would not. My reasoning for this is because the HSV resides within nerve ganglion and moves down the nerve to begin an infection. Until this happens, the virus is hidden from the immune system and therefore the rest of the body. The HIV virus however transmits itself by infecting white blood cells (mostly helper T cells) and incorporates its RNA into the cells DNA. This happens in ?plain site? but the body is hard pressed in attempt to defeat it because its rapid mutations quickly alter the virus?s antigenic nature This being said, both viruses infect different systems of the body, nervous and immune so I would not see a definite relation. My apologies if I mentioned information you already knew. |
Subject:
Re: herpes simplex virus 2 and its influence on the progression of AIDS
From: pforcelli-ga on 19 Jul 2006 20:41 PDT |
From the Journal of Medical Virology, (Effect of multiple herpesvirus infections on the progression of HIV disease in a cohort of HIV seroconverters., Suligoi et al. Feb 2003, 69(2):182-7.) It does not appear, from this study, that HSV-2 speeds the progression of HIV to AIDS. However, a statistical link between HHV-8 and both Kaposi's sarcoma and subthreshold (<200x10^6 cells/L) CD4+ cell levels was found. You should note, that HSV-2 coinfection with HIV does statistically increase the number of Herpes reactivations, likely due to the immune supression and stress which are known triggers for HSV reactivation (Shacker T. Herpes, 2001 Jul; 8(2):46-9.) It is also worthy of note that it has been reported (Celum, Herpes. 2004 Apr; 11 Suppl. 35-45) that HSV-2 does statistically increase HIV replication. The picture will become clearer as larger and more accurate clinical studies are conducted. So my answer: It may. It may not. We don't know yet. |
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