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Q: aurorix after cipralex ( Answered 4 out of 5 stars,   0 Comments )
Subject: aurorix after cipralex
Category: Health > Medicine
Asked by: demis7071-ga
List Price: $20.00
Posted: 19 Sep 2006 13:58 PDT
Expires: 19 Oct 2006 13:58 PDT
Question ID: 766705
I' m starting to taking aurorix after cipralex. I low down cipralex
from 10mg/day to 5 mg per day and I started aurorix with 75(1/2 of
150mg) per day for now 3 days.
But I have some problems of headache, nausea and some others...
Is tis from stoping cipralex or from starting aurorix? In how many
days I will take some benefit from aurorix (I have especially social
Subject: Re: aurorix after cipralex
Answered By: livioflores-ga on 20 Sep 2006 00:31 PDT
Rated:4 out of 5 stars

According to my research both actions (starting aurorix and stopping
cipralex) can cause the side effects you are experiencing (headache,
nausea and some others):
"Effects when treatment with Cipralex is stopped:
Stopping this kind of medication quickly may cause discontinuation
symptoms such as dizziness, nausea and headache. When you have
completed your course of treatment it is therefore advised that the
dose of Cipralex is gradually reduced over a couple of weeks."
From "CIPRALEX FILM-COATED TABLETS - Electronic Medicines Compendium":

"AURORIX helps most people with depression but it may have unwanted
side effects in a few people. All medicines can have side effects.
Sometimes they are serious, most of the time they are not. You may
need medical treatment if you get some of the side effects.
Ask your doctor or pharmacist to answer any questions you may have.
In the first week or two you may experience:
* Sleep disturbances, dizziness, nausea, headache."
From "AURORIX - Moclobemide - Consumer Medicine Information":

I looked for but have not found info regarding interaction between
Aurorix (moclobemide) and Cipralex (escitalopram), that is there are
not known (or informed) interactions between these two drugs.
BUT, considering that Aurorix is a Monoamine oxidase inhibitors
(MAOIs) (actually it is a reversible inhibitor of monoamine oxidase A
(RIMA), that is a subset of MAOIs) and Cipralex is a selective
serotonin reuptake inhibitor (SSRI), the following paragraphs MUST BE
discussed with your doctor:
"Concomitant Use: ...
Clinical data are not available on the concomitant use of MANERIX and
selective serotonin reuptake inhibitors, or conventional monoamine
oxidase inhibitors. Therefore, until clinical data become available,
MANERIX should not be administered in combination with these agents.
Sequential Use: ...
When switching patients from serotonergic antidepressants to a
conventional MAO-inhibitor, it is standard practice to allow for a
washout period equivalent to at least 4-5 half-lives of the previously
administered drug or any active metabolites. This recommendation also
applies to MANERIX."
From "DRUG INTERACTIONS" section (page 5) of MANERIX® (moclobemide)
PRODUCT MONOGRAPH from Roche Canada (the manufacturer):
Note that Manerix and Aurorix are brand names of the same drug, moclobemide.

And this one also:
"Switching Patients To or From a Monoamine Oxidase Inhibitor:
At least 14 days should elapse between discontinuation of a MAOI and
initiation of LEXAPRO therapy. Similarly, at least 14 days should be
allowed after stopping LEXAPRO before starting a MAOI"
From "Lexapro Indications, Dosage, Storage, Stability - Escitalopram
Oxalate - RxList Monographs":
Note that Lexapro and Cipralex are brand names for the same drug, escitalopram.

Regarding to how long you must wait to see some benefit from aurorix,
the answer of this is out of my scope, even your doctor cannot give
you this answer accurately.
According to many sources usual dosage for the treatment of social
phobia is 300 mg orally each day for 3 days, then 300 mg twice daily
after food. Assess efficacy after 8-12 weeks.
The following paragraphs will be useful to you:
"Treatment of social phobia:
The recommended dose of moclobemide is 600mg/day, given in 2 divided
doses. The moclobemide dose should be started at 300mg/day and should
be increased to 600mg/day on day 4. Continuing the 300mg/day dose for
longer than 3 days is not recommended, as the efficacious dose is
600mg/day. Treatment with 600mg/day should continue for 8 - 12 weeks
in order to assess the efficacy of the drug. Social phobia may be a
chronic condition and it is reasonable to consider continuation of
treatment for a responding patient. Patients should be periodically
re-evaluated to determine need for further treatment."
From "Manerix - Summary of Product Characteristics - Electronic
Medicines Compendium":

"How long to take AURORIX:
The length of treatment will depend on how quickly your symptoms
improve. Most antidepressants take time to work so don't be
discouraged if you don't feel better right away. Some of your symptoms
may improve in 1 or 2 weeks but it can take up to 4 or 6 weeks to feel
any real improvement if you have depression.
Social phobia may be a chronic condition and treatment should continue
for 8 to 12 weeks at least. Even when you feel well, you will usually
have to take AURORIX for several months or even longer to make sure
the benefits will last. Continue taking it until your doctor tells you
to stop."
From "AURORIX - Consumer Medicine Information":

For further readings see:

"Lexapro Online, Description, Chemistry, Ingredients, Blackbox -
Escitalopram Oxalate - RxList Monographs":

"CIPRALEX FILM-COATED TABLETS - Summary of Product Characteristics -
Electronic Medicines Compendium":

Search strategy:
aurorix "social phobia"

I hope this helps you. Feel free to request for a clarification if you
find something unclear and/or incomplete on this answer before rate
it. i will be glad to give you further assistance on this question if
you need it.

Best regards,
demis7071-ga rated this answer:4 out of 5 stars

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