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Q: Research Studies on These Nutritional Ingredients And Their Effect On Sleep ( Answered,   0 Comments )
Subject: Research Studies on These Nutritional Ingredients And Their Effect On Sleep
Category: Health
Asked by: miramo-ga
List Price: $75.00
Posted: 15 Oct 2006 02:29 PDT
Expires: 14 Nov 2006 01:29 PST
Question ID: 773604
I am in need of documentation of research studies done regarding each
of these nutrients/herbals and their effect on insomnia, sleep, sleep
quality, general health.







Passion Flower 

Subject: Re: Research Studies on These Nutritional Ingredients And Their Effect On Sleep
Answered By: politicalguru-ga on 15 Oct 2006 08:01 PDT
Dear Miramo, 

Achterrath-Tuckermann U, Kunde R, Flaskamp E, Isaac O, Thiemer K.
Pharmacological investigations with compounds of chamomile. Part 5.
Investigations on the spasmolytic effect of compounds of chamomile and
Kamillosan on the isolated guinea pig ileum.
Planta Medica 1980; 39:38-50.

Alisky JM. 
Niacin improved rigidity and bradykinesia in a Parkinson's disease
patient but also caused unacceptable nightmares and skin rash--a case
Nutrition & Neuroscience. 2005 Oct-Dec;8(5-6):327-9.

Avallone R, Zanoli P, Corsi L, Cannazza G, Baraldi M.
Benzodiazepine-like compounds and GABA in flower heads of Matricaria
Phytotherapy Research 1996; 10:S177-S179.

Balderer G, Borbely AA. Effect of valerian on human sleep.
Psychopharmacology (Berl). 1985;87(4):406-409.

Brzezinski, A. Melatonin in Humans. The New England Journal of
Medicine, 336(3),186-195.

Buscemi N., Vandermeer B., Pandya R., et al. Melatonin for Treatment
of Sleep Disorders. Summary, Evidence Report/Technology Assessment:
Number 108. AHRQ Publication Number 05-E002-1, November 2004. Agency
for Healthcare Research and Quality, Rockville, MD.

Cauffield JS, Forbes HJ.
Dietary supplements used in the treatment of depression, anxiety, and
sleep disorders.
Lippincotts Primary Care Practice. 1999 May-Jun;3(3):290-304.

Chase JE, Gidal BE. Melatonin: Therapeutic use in sleep disorders. Ann
Pharmacother. 1997;31:1218-1225.

The use of alternative medicine for the treatment of insomnia in the elderly
Psychogeriatrics Volume 6 Page 21  - March 2006

Didier Chollet, Paul Franken, Yvette Raffin, Alain Malafosse, Jean
Widmer, and Mehdi Tafti
Blood and brain magnesium in inbred mice and their correlation with sleep quality
American Journal of Regulatory, Integrative and Comparative
Physiology, Vol. 279, Issue 6, R2173-R2178, December 2000

Didier Chollet1, Paul Franken1, Yvette Raffin1, Jean-Georges
Henrotte2, Jean Widmer1, Alain Malafosse1 and Mehdi Tafti1
Magnesium Involvement in Sleep: Genetic and Nutritional Models
Behavior Genetics, Volume 31, Number 5 / September, 2001

Claustrat, B., Brun, J., David, M., Sassolas, G., & Chazot, G. (1992).
Melatonin and Jet Lag: Confirmatory Result Using a Simplified
Protocol. Biological Psychiatry, 32, 705-711.

De la Motte S, Bose-O'Reilly S, Heinisch M, Harrison F. Double-blind
comparison of a preparation of pectin/chamomile extract and placebo in
children with diarrhea.
Arzneimittel Forschung 1247; 47:1247-1249.

Depoortere H, Francon D, Llopis J.
Effects of a magnesium-deficient diet on sleep organization in rats.
Neuropsychobiology. 1993;27(4):237-45. 	

Donath F, Quispe S, Diefenbach K, Maurer A, Fietze I, Roots FI.
Critical evaluation of the effect of valerian extract on sleep
structure and sleep quality. Pharmacopsychiatry. 2000;33:47-53.

Durlach J et al. Magnesium and therapeutics. Magnes Res 7(3/4):313-28, 1994

Fenz ZY, Guo DW, Su S, Zhao H, Zheng XX (2002) Sedative and
anticonvulsant effect of jujuboside A. Zhejiang Da Xue Xue Bao Yi Xue

Ferini-Strambi L, Zucconi M, Biella G, et al. Effect of melatonin on
sleep microstructure: preliminary results in healthy subjects. Sleep.

Garfinkel, D., Laudon, M., Nof, D., & Zisapel, N. (1995). 
Improvement of sleep quality in elderly people by controlled-release
melatonin. The  Lancet, 346, 541-543.

Garfinkel D, Zisapel N, Wainstein J, Laudon M. Facilitation of
benzodiazepine discontinuation by melatonin: a new clinical approach.
Arch Intern Med. 1999;159(8):2456-2460.

Gould L, Reddy CVR, Gomprecht RF. Cardiac effects of chamomile tea. Journal of
Clinical Pharmacology & New Drugs 1973; 13:475-479

Gyllenhaal C. Efficacy and safety of herbal stimulants and sedatives
in sleep disorders. Sleep Med Rev. 2000;4(2).

Haimov I, Laudon I, Zisapel N, Souroujon M, Nof D, Shiltner A, et al.
Sleep disorders and melatonin rhythms in elderly people. BMJ.

Hornyak M, Voderholzer U, Hohagen F, et al. Magnesium therapy for
periodic leg movements-related insomnia and restless legs syndrome: an
open pilot study. Sleep 1998;21:501-5.

Jan, J. (1994). The Treatment of Sleep Disorders With Melatonin.
Developmental Medicine and Child Neurology, 36, 97-107.

Jan JE, Espezel H, Appleton RE. The treatment of sleep disorders with
melatonin. Dev Med Child Neurol. 1994;36(2):97-107.

Jan JE, Espezel H, Freeman RD, Fast DK. Melatonin treatment of chronic
sleep disorders. J Child Neurol. 1998; 13(2):98.

Jungryun Lee, Daesoo Kim *, and Hee-Sup Shin
Lack of delta waves and sleep disturbances during non-rapid eye
movement sleep in mice lacking {alpha}1G-subunit of T-type calcium
PNAS | December 28, 2004 | vol. 101 | no. 52 | 18195-18199 

Sleep and the vascular action of nicotinic acid.
Confin Neurol. 1960;20:355-65. 

Kayumov L, Zhdanova IV, Shapiro CM.
Melatonin, sleep, and circadian rhythm disorders.
Seminars in Clinical Neuropsychiatry. 2000 Jan;5(1):44-55.

Kripke, DF P Lavie, D Parker, L Huey and LJ Deftos 
Plasma parathyroid hormone and calcium are related to sleep stage cycles
Journal of Clinical Endocrinology & Metabolism, Vol 47, 1021-1027

Leathwood PD, Chauffard F, Heck E, Munoz-Box R: Aqueous extract of
valerian root (Valeriana officinalis L.) improves sleep quality in
man. Pharmacology, Biochemistry and Behavior 17: 65-71, 1982.

Lino, A., Silvy, S., Condorelli, L., & Rusconi, A. (1993). Melatonin and Jet
Lag: Treatment Schedule. Biological Psychiatry, 34, 587.

Martens D. Chamomile: The Herb and the Remedy. Prover, The Journal of the
Chiropractic Academy of Homeopathy 1995; 6:15-18

Nagtagaal JE, Laurant MW, Kerkhof GA, Smits MG, van der Meer YG,
Coenen AM. Effects of melatonin on the quality of life in patients
with delayed sleep phase syndrome. J Psychosom Res. 2000;48(1):45-50.

Elisabeth Ngo Buma1, Esther Ngahb Benoite Charlotte Ekoundic,
Christian Dongc, Rigobert Espoir Ayissi Mbomoc, SilvereVincent
Rakotonirinac, Alice Rakotonirinac
African Journal. Traditional, Complementary and Alternative Medicines
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Park JH, Lee HJ, Koh SB, Ban JY, Seong YH (2004) Protection of
NMDA-induced neuronal cell damage by methanol extract of zizyphi
semen in cultured rat cerebellar granule cells. J Ethnopharmacol. 95(1):39-45.

Penland J. Effects of trace element nutrition on sleep patterns in
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Pierce, James B. _Heart Healthy Magnesium_, Avery Publishing Group

Pillar G, Shahar E, Peled N, Ravid S, Lavie P, Etzioni A. Melatonin
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Popoviciu L et al. Clinical, EEG, electromyographic and
polysomnographic studies in restless legs syndrome caused by magnesium
deficiency. Rom J Neurol Psychiatry 31(1):55-61, 1993

Rechtschaffen, A. and Siegel, J.M. Sleep and Dreaming. In: Principles of
Neuroscience. Fourth Edition, Edited by E. R. Kandel, J.H. Schwartz and
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(search for "calcium")

Reimund E. 
Sleep deprivation-induced dermatitis: further support of nicotinic
acid depletion in sleep deprivation.
Med Hypotheses. 1991 Dec;36(4):371-3

Reimund E. 
Sleep deprivation-induced neuronal damage may be due to nicotinic acid depletion.
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Rommel T, Demisch L. Influence of chronic beta-adrenoreceptor blocker
treatment on melatonin secretion and sleep quality in patients with
essential hypertension. J Neural Transm Gen Sect. 1994;95:39-48.

Sack RL, Hughes RJ, Edgar DM, Lewy AJ. Sleep-promoting effects of
melatonin: at what dose, in whom, under what conditions, and by what
mechanisms? Sleep. 1997;20(10):908-915.

Mildred S. Seelig, MD, MPH and Andrea Rosanoff, PhD , _The Magnesium
Factor>_ Avery Publishing Group

Shamir E, Laudon M, Barak Y, Anis Y, Rotenberg V, Elizur A, Zisapel N.
Melatonin improves sleep quality of patients with chronic
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Shinomiya K, Inoue T, Utsu Y, Tokunaga S, Masuoka T, Ohmori A, Kamei C.
Hypnotic activities of chamomile and passiflora extracts in sleep-disturbed rats.
Biological and Pharmaceutuical Bulletin. 2005 May;28(5):808-10.

Skene DJ, Lockley SW, Arendt J. Use of melatonin in the treatment of
phase shift and sleep disorders. Adv Exp Med Biol. 1999;467:79-84.

Smits MG, Nagtegaal EE, van der Heijden J, Coenen AM, Kerkhof GA.
Melatonin for chronic sleep onset insomnia in children: a randomized
placebo-controlled trial. J Child Neurol. 2001;16(2):86-92.

Soulimani R, Younos C, Jarmouni S, Bousta D, Misslin R, Mortier F.
Behavioural effects of Passiflora incarnata L. and its indole alkaloid
and flavonoid derivatives and maltol in the mouse.
J Ethnopharmacol. 1997 Jun;57(1):11-20.

Stevinson C, Ernst E: Valerian for insomnia: a systematic review of
randomized clinical trials. Sleep Medicine 1: 91-99, 2000

Tyler, V.E. 1999. Herbs affecting the central nervous system. p.
442?449. In: J. Janick (ed.), Perspectives on new crops and new uses.
ASHS Press, Alexandria, VA.

Tzischinsky O, Lavie P. Melatonin possesses time-dependent hypnotic
effects. Sleep. 1994;17:638?645.

Viola H, Wasowski C, Levi de Stein M, et al. 
Apigenin, a component of Matricaria recutita flowers, is a central
benzodiazepine receptors-ligand with anxiolytic effects.
Planta Medica 1995; 61:213-6.

Warren C. Wacker _Magnesium and Man_  Harvard University Press 1980

Wu SX, Zhang JX, Xu T, Li LF, Zhao SY, Lan MY (1993) Effects of seeds,
leaves and fruits of Ziziphus spinosa and jujuboside A on central
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S N Young
Melatonin, sleep, aging, and the health protection branch.
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?Wang Yuangyang,Huang Dengyu,Wu Qiuling?
Experimental Study of Sleep Improvement Function on Oral Solution of
Wild Jujube Seed & RoyalJelly? ?
[in Chinese! --->

Zal HM. Five herbs for depression, anxiety, and sleep disorders. Uses,
benefits, and adverse effects. Consultant. 1999;3343-3349.

Zhdanova IV, Wurtman RJ, Morabito C, Piotrovska VR, Lynch HJ. Effects
of low oral doses of melatonin, given 2-4 hours before habitual
bedtime, on sleep in normal young humans. Sleep. 1996;19:423?431.

Zhdanova, I. (1995). Sleep - inducing effects of low doses of
melatonin ingested in the evening. Clinical Pharmacology &
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Further Resources
Carden, Dr. William B  
Functional and molecular analysis of long-term sleep disruption by
ethanol (research project)
< > 

General research about camomile could be found at: 
University of Maryland Medical Centre, German Chamomile 

About Calcium:
University of Maryland Medical Centre, Calcium

About Magnesium

About Melatonin 

About Niacin

About Passionflower

I hope this answers your question. Please contact me if you need any
clarification on this answer before you rate it. Search strategy:
[name of component, e.g. Valerian] [sleep/insomnia/other "sleep" terms] 
- Google Scholar
- Google Index
- Google Index with [site:edu] term
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