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Q: interaction between ssri antidepressants and endocannabinoid antagonists(Rimonab ( Answered,   1 Comment )
Subject: interaction between ssri antidepressants and endocannabinoid antagonists(Rimonab
Category: Science
Asked by: val1-ga
List Price: $40.00
Posted: 05 Nov 2006 12:20 PST
Expires: 05 Dec 2006 12:20 PST
Question ID: 780313
is there an interaction between antidepressants and endocannabinoid
antagonists (Acompli). A pharmacological interaction.
Subject: Re: interaction between ssri antidepressants and endocannabinoid antagonists(Rim
Answered By: keystroke-ga on 04 Dec 2006 13:16 PST
Hello val1,

Thank you for your question.

The answer to your question, according to the most recent available
scientific research, appears to be no, at least in a negative way. 
The drugs continue to work and prevent depression and weight loss
despite being taken together and do not negatively affect the patient
taking them simultaneously.

"Antidepressant-induced undesirable weight gain: Prevention with
rimonabant without interference with behavioral effectiveness."

At Pubmed:

"The acute studies indicated that rimonabant [Acomplia's chemical
name] did not influence 'antidepressant' activity of desipramine or
fluoxetine... The antidepressant effects of desipramine were
maintained throughout treatment; this was not altered by the chronic
rimonabant treatment at any time, although rimonabant together with
desipramine transiently enhanced anxiety-like behavior. These
observations suggest that combined treatment with antidepressants and
cannabinoid CB(1) receptor antagonist to prevent undesirable weight
gain, should be further investigated."

Before this Israeli study, the subject had not been studied well, and
Acomplia is still not recommended for use in patients who are on
antidepressants.  Further research needs to be done.

Rimonabant has caused depressive side effects in numerous test cases. 
The studies that have been conducted with Acomplia have been
complicated by the fact that many patients deciding to take the drug
are obese, and many obese people are already depressed.  Many of the
people involved in the study grew more depressed over the course of
the study, despite losing weight.  While it is not known exactly what
is causing the side effects of depression, other studies are currently
being conducted to determine what exactly is causing the problems and
how it can be dealt with.  This is a factor which has helped to
prevent the drug's approval in the United States.

Therefore, antidepressants and Acomplia go together well, because
antidepressants work well with helping depression but can cause weight
gain, and Acomplia works well with preventing weight gain but can
cause depression.


"Anti-obesity drug"

"Diet Pill Acomplia May Prevent Weight Gain Common to Antidepressants"

Search terms:
acomplia weight loss
rimonabant antidepressant

If you need any additional clarification, let me know and I'll be glad
to assist you.

Subject: Re: interaction between ssri antidepressants and endocannabinoid antagonists(Rimonab
From: nickyc8013-ga on 30 Nov 2006 10:19 PST
Im not sure, but these links may help.
Otherwise i cant really help you out.

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