I have had Paternal Leukocyte Immunization treatment in London after
recurrent early miscarriages. The only known provider of the treatment
in the UK, to my knowledge, is Mr. Paul Armstrong, who is currently
unable to offer the service. I am seeking other places where the
treatment can be done, which are accessible to someone living in the
UK (The treatment does not have to be undertaken in the UK, but UK,
US, or Europe would be preferable).I would be grateful for any
information which might help me to find a place where I might get the
treatment again.
thanks, Nina Adamyk

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Request for Question Clarification by silviares-ga on 14 Nov 2002 08:45 PST

Hello percygreen-ga 

I have been doing some research in regard to your question.
So far I have only searched in the US but the answers here have been
discouraging.
One of the fertility and reproduction doctors I contacted sent me this
answer:

"
Paternal white cell immunization is no longer offered in the USA.  It
currently under review by the FDA.  I am not able to make
recommendations
outside of this country (liability matter).  IVIg is a very good
alternative.
If the person is welcome to call my office for a telephone
consultation if
she is interested in pursuing this.
"

I also found some test results from a BlueCross BlueShield Association
Technology Evaluation Center (TEC) assessment of 1995. (1) In
addition, an updated MEDLINE search was completed through April 10,
2002.

TEC concluded that the available evidence was inadequate to determine
if this therapy reduces fetal loss. Conflicting results were reported
from the seven controlled trials (n=411) of paternal leukocyte therapy
that were reviewed. Three of these trials showed significant favorable
differences between treatment and control groups, one trial showed a
slight favorable difference that was not significant, and 3 trials
showed unfavorable, albeit nonsignificant, differences.

In addition, an updated MEDLINE search was completed through April 10,
2002.
You can see the details at
http://www.regence.com/trgmedpol/medicine/med20.html

Also on the Aetna web site http://www.aetna.com/cpb/data/CPBA0348.html

" Recent meta-analyses of randomized controlled trials of
immunotherapy for recurrent miscarriage concluded that IVIG and
paternal leukocyte injections provided no significant beneficial
effect over placebo in preventing further miscarriages (21). The
investigators also found no significant benefit for other
immunological treatments that have been used for recurrent
miscarriage: third party donor cell immunization and trophoblast
membrane infusion. "

You might already be aware of all this but I just wanted to make sure
of that.
If you still want to pursue this search I will be happy to keep
searching for a doctor that perform the procedure in Europe.
Just let me know

Silviares

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Clarification of Question by percygreen-ga on 14 Nov 2002 13:50 PST

Thanks for your information. I am interested in any places in europe
or that are accessible from the UK (the only one I know of is in
Israel, which is not ideal, although there may be a possible place in
athens. I have heard the conflicting info about success, but can only
say it was the only thing that helped last time (not conclusive I
know). The other treatment you mentioned we are less keen on, as I
believe it is ongoing throughout pregnancy (this isn't)
Thanks for your help so far. (If the answer is there are no such
places, obviously you must still claim your fee, as you have put work
into it!)

---

Request for Question Clarification by silviares-ga on 18 Nov 2002 14:03 PST

Dear percygreen-ga 

during my researches to find an answer to your question I was pointed
to Dr. Alan Beer in Chicago, Finch University of Health Sciences at
The Chicago Medical School(http://repro-med.net/litfdaind2.html).

I contacted doctor Beer and got his answer this morning. Here is the
answer:

"
MY CENTER IN LONDON WILL BE OFFERING THE LIT THERAPY AS SOON AS I
RECEIVE MY REGISTRATION.  I SHOULD KNOW THE STATUS OF THIS DECEMBER
5TH.  IF I AM GRANTED THE LICENSE THEN I WILL BE COMING TO LONDON TO
START THE IMMUNIZATION SERVICE PERSONALLY IN DECEMBER.  REGISTER WITH
MY OFFICE SO THAT WE KNOW IF YOU ARE A CANDIDATE.

WARM REGARDS

ALAN E BEER, MD
"

Doctor Beer contact information are

Alan E. Beer, M.D.
Tel: (847) 578-3233
E-mail: beerdoc@aol.com


Let me know if you want to contact him directly or if you want me to
find out
more information.

I'm still waiting for more answers from other clinics and doctors in
Europe and I will keep you posted on what I find

silviares

---

Clarification of Question by percygreen-ga on 18 Nov 2002 15:02 PST

Thanks for your hard work. That is really useful and I will contact
him to register my interest. Please register the question as answered
(or however it works so that you do get paid, never used this before),
as it sounds as if you have put a lot of work in. Thanks again for the
info!
-Nina

Hi Nina 
as you suggested I will post the previous information as an answer.
I'm glad I was able to help. If I will receive answers from other
clinics I contacted I will post any new information as an answer
clarification.
I really hope the treatment works for you and I whish you the best of
luck

silvia

Dear percygreen-ga  
 
during my researches to find an answer to your question I was pointed
to Dr. Alan Beer in Chicago, Finch University of Health Sciences at
The Chicago Medical School(http://repro-med.net/litfdaind2.html).
 
I contacted doctor Beer and got his answer this morning. Here is the
answer:
 
" 
MY CENTER IN LONDON WILL BE OFFERING THE LIT THERAPY AS SOON AS I
RECEIVE MY REGISTRATION.  I SHOULD KNOW THE STATUS OF THIS DECEMBER
5TH.  IF I AM GRANTED THE LICENSE THEN I WILL BE COMING TO LONDON TO
START THE IMMUNIZATION SERVICE PERSONALLY IN DECEMBER.  REGISTER WITH
MY OFFICE SO THAT WE KNOW IF YOU ARE A CANDIDATE.
 
WARM REGARDS 
 
ALAN E BEER, MD 
" 
 
Doctor Beer contact information are 
 
Alan E. Beer, M.D. 
Tel: (847) 578-3233 
E-mail: beerdoc@aol.com 
 
 
Let me know if you want to contact him directly or if you want me to
find out
more information. 
 
I'm still waiting for more answers from other clinics and doctors in
Europe and I will keep you posted on what I find
 
silviares

---

Clarification of Answer by silviares-ga on 19 Nov 2002 14:55 PST

Hi Nina

thank you for the compliments and the good ratings.
I received email today from another of the clinics I contacted. 
They say that for the procedure you requested they refer their patient to 
Dr. Harris Mantouvalos in Greece 30-1-722-0575. 
104 Praxitelous St GR - 15-32 Piraeus Greece -

I thought I would pass the information to you in case you will need a back up
plan

Silvia

Helpful, clear information. researcher found out useful things I had
not in my internet searches! Many thanks!
-Nina

This is a very good question. In the United States, I think the FDA
has 'pulled the plug' on further testing until each of the units
providing this service gets a new IND (investigational new drug)
application put through. My references are sketchy, but they show a
several month backlog.

I'll keep looking -

SgtCory

I have found a mention of this treatment being offered at UCLA
(University of California, Los Angeles) "The Recurrent Pregnancy Loss
Treatment Program provides consultation, evaluation, and treatment
services for women who have suffered from recurrent pregnancy losses.
Immunologic testing, paternal leukocyte immunization, and
psychological support groups are available."
http://www.healthcare.ucla.edu/handbook/program.asp?version=5619&programid=305

However, since there is no date given for this information, since I am
unable to telephone to verify it (I too am in the UK), and in view of
the previous comment, I leave this as a comment rather than as an
answer.

thanks for these comments! -Nina

Hi, 
the department of obstetrics and gynecology of the University Hospital
of Kiel, North Germany used to have an actice and busy program for
immunological treatment for recurrent miscarriages.
You should be aware that there is no scientific evidence based on good
studies that this treatment works at all.
Should you continue to have miscarriages, then I would consult the
most reputed gynecologist in the largest city wherever you live. This
gynecologist should have special interest and experience in management
of recurrent miscarriages and you should undergo a thorough exam.

Many thanks, sylvia!

-Nina