Greetings debs50,
Thanks for your question on the medication Mobic {meloxicam} today.
I've taken the liberty of finding a wide range of information on this
drug at varying levels of understanding. If you could please skip
over the sections with which you are already familiar and ask for
clarification if any of this information is unclear.
My first stop in locating your information was to try www.mobic.com.
Usually drug names have their own website categorized on the internet.
However, the manufactures of Mobic {Boehringer Ingelheim} has this
drug listed under "mobictablet.
==========================
MOBIC INFORMATION
==========================
Mobic (meloxicam):
http://www.mobictablet.com
-----------
Physician's Desk Reference:
http://www.healthandage.com/html/res/pdr/html/08600200.htm
The following is a list of adverse drug reactions occurring in < 2% of
patients receiving MOBIC in clinical trials involving approximately
15,
400 patients. Adverse reactions reported only in worldwide post-
marketing experience or the literature are shown in italics and are
considered rare(< 0.1%).
Body as a Whole: allergic reaction, anaphylactoid reactions including
shock, face edema, fatigue, fever, hot flushes, malaise, syncope,
weight decrease, weight increase Cardiovascular: angina pectoris,
cardiac failure, hypertension, hypotension, myocardial infarction,
vasculitis Central and Peripheral Nervous System: convulsions,
paresthesia, tremor, vertigo Gastrointestinal: colitis, dry mouth,
duodenal ulcer, eructation, esophagitis, gastric ulcer, gastritis,
gastroesophageal reflux, gastrointestinal hemorrhage, hematemesis,
hemorrhagic duodenal ulcer, hemorrhagic gastric ulcer, intestinal
perforation, melena, pancreatitis, perforated duodenal ulcer,
perforated gastric ulcer, stomatitis ulcerative Heart Rate and Rhythm:
arrhythmia, palpitation, tachycardia Hematologic: agranulocytosis,
leukopenia, purpura, thrombocytopenia Liver and Biliary System: ALT
increased, AST increased, bilirubinemia, GGT increased, hepatitis,
jaundice, liver failure Metabolic and Nutritional: dehydration
Psychiatric Disorders: abnormal dreaming, anxiety, appetite increased,
confusion, depression, nervousness, somnolence Respiratory: asthma,
bronchospasm, dyspnea Skin and Appendages: alopecia, angioedema,
bullous eruption, erythema multiforme, photosensitivity reaction,
pruritus, Stevens-Johnson syndrome, sweating increased, toxic
epidermal necrolysis, urticaria Special Senses: abnormal vision,
conjunctivitis, taste perversion, tinnitus Urinary System:
albuminuria,
BUN increased, creatinine increased, hematuria, interstitial
nephritis, renal failure.
-------------
Revised Product Summary {6/26/02}:
http://216.239.51.100/search?q=cache:shwEwAbHPq8C:www3.mpa.se/spc/SPC.F-N/Mobic_supp_15mgENG.pdf+"adverse+reactions"+"mobic"+"2002"&hl=en&ie=UTF-8
-------------
Mobic Indications:
http://arthritis.about.com/library/blmobic.htm
What is Mobic used for?
Mobic is used to relieve the signs and symptoms of osteoarthritis in
adults.
Who should not take Mobic?
You should not take Mobic if you have experienced asthma, hives, or
allergic-type reactions after taking aspirin or other nonsteroidal
anti-inflammatory drugs (NSAIDs). A few examples of other NSAIDs are
ibuprofen, naproxen, diclofenac, nabumetone, and ketoprofen.
Mobic Systemic Information:
http://www.nlm.nih.gov/medlineplus/druginfo/meloxicamsystemic500131.html
========================
PANCREATITIS
========================
http://www.nlm.nih.gov/medlineplus/ency/article/001144.htm
Pancreatitis is inflammation of the pancreas, a gland that lies behind
the stomach. The pancreas produces the hormones insulin and glucagon
to control metabolism. It also produces other hormones and enzymes to
aid digestion of fats, proteins, and carbohydrates. The hormones and
enzymes flow from the pancreas through the pancreatic duct into the
upper part of the small intestine (duodenum).
Inflammation occurs when the digestive enzymes attack the pancreas.
The inflammation may occur suddenly (acute pancreatitis) or develop
over many years (chronic pancreatitis).
----------------
WebMD/Pancreatitis:
http://my.webmd.com/encyclopedia/article/4115.20932
==================
CONCLUSION
==================
In relation to the above information, pancreatitis lies in the 'rare'
risk category for patients taking Mobic. Therefore, with regard to
your specific question "Does Mobic cause pancreas inflammation?" I
would have to say an equivocal "no"; Mobic in and of itself does not
cause pancreatitis, but any underlying conditions would need to be
assessed by your physician. Google Answers is in no way a substitute
for expert medical advice.
The reason I used the word 'equivocal' is because meloxicam is closely
related to the drug piroxicam in which a pancreatitis connection is
cited in the literature. Without proper critical review, I can't
state with certainty that there are additional risk factors for those
taking piroxicam. The following studies might be of interest to you
in assessing the risks of NSAIDs, and piroxicam and meloxicam in
particular. Please feel free to discuss these studies with your
doctor or a health professional.
================
From PubMed
================
Jick H, Derby LE, Garcia Rodriguez LA, Jick SS, Dean AD.
Nonsteroidal antiinflammatory drugs and certain rare, serious adverse
events: a cohort study.
Pharmacotherapy. 1993 May-Jun;13(3):212-7.
PMID: 8321735
----------
Mallory A, Kern F.
Drug-induced pancreatitis.
Baillieres Clin Gastroenterol. 1988 Apr;2(2):293-307. Review.
PMID: 3044464
----------
Haye OL.
Piroxicam and pancreatitis.
Ann Intern Med. 1986 Jun;104(6):895. No abstract available.
PMID: 3706949
======================
FROM LANCET
======================
{note, I had to register here to access this information but the
entire abstract is only available to Lancet subscribers.}
http://www.thelancet.com/journal/vol357/iss9257/abs/llan.357.9257.original_research.15414.1
The safety of cyclo-oxygenase 2 (COX-2) preferential inhibitors such
as meloxicam is debated. We describe a patient who presented with
bloody diarrhoea after 15 mg meloxicam daily for 10 days for
osteoarthritis. The endoscopic and histological features were
consistent with the diagnosis of ischaemic colitis. Symptoms and
endoscopic lesions quickly regressed within 1 week of meloxicam
withdrawal. There was no evidence of another cause of colonic
ischaemia. We suggest that meloxicam might have intestinal toxic
effects when taken in high doses, because of reduced COX-2
selectivity.
--------------------------------------------------------------------------------
Service d'Hépato-Gastroentérologie, Laboratoire Central d'Anatomie et
de Cytologie Pathologiques, CHU Robert Debré, 51092 Reims Cedex,
France (B Garcia MD, F Ramaholimihaso MD, Prof M-D Diebold MD, Prof G
Cadiot, Prof G Thiéfin MD)
--------------------------------------------------------------------------------
Correspondence to: Prof Gérard Thiéfin (e-mail:gthiefin@chu-reims.fr)
===================
FROM MDBROWSE
===================
http://www.mdbrowse.com/Speciality/Clinical-pharma/MeloxicamAdverseReactions.htm
Richard M Martin, Pipasha Biswas and Ronald D. Mann (Drug Safety
Research Unit, Bursledon Hall, Southampton and School of Medicine,
Faculty of Medicine and Biological Sciences, University of
Southampton,
UK).
The incidence of adverse events and risk factors for upper
gastrointestinal disorders associated with meloxicam use amongst 19087
patients in general practice in England: cohort study.
Br.J.Clin.Pharmacol, 50(1),July 2000, 35-42.
Conclusion was that in the absence of gastrointestinal risk factors,
incidence of GI disturbance was low. Such risk factors should be
carefully reviewed prior to prescribing meloxicam.
==============================
INCIDENTAL INFORMATION
==============================
Boehringer-Ingelheim News:
http://www.boehringer-ingelheim.com/corporate/asp/news/ndetail.asp?ID=269
Boehringer Ingelheim continues its commitment to discovering and
developing innovative therapeutics for treatment of chronic
inflammatory diseases. A parenteral formulation of meloxicam for the
initial treatment of painful inflammatory conditions was recently
approved in Europe via a mutual recognition procedure and is now
available in most European countries. Promising drug candidates in
clinical development include inhibitors for cell adhesion molecules
and cell signalling, such as LFA-1antagonists or p38 MAP kinase
inhibitors, for the treatment of diseases such as rheumatoid
arthritis,
psoriasis and Crohn’s disease.
----------
British Medical Association and the Royal Pharmaceutical Society of
Great Britain:
http://bnf.vhn.net/bnf/documents/bnf.1929.html
---------
Australia Drug Watch List:
http://www.health.gov.au/tga/docs/html/aadrbltn/aadr0202.htm
---------
Public Citizen Watch List:
http://www.citizen.org/eletter/articles/psychiatric.htm
Family: Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)
Reactions: Depression, paranoia, psychosis, confusion, anxiety
Notes: Probably more common with indomethacin (INDOCIN); one case of
auditory hallucinations with celecoxib (CELEBREX)
Examples: Ibuprofen (MOTRIN); naproxen (NAPROSYN); meloxicam (MOBIC);
rofecoxib (VIOXX)
----------
Immunotherapy and Immunomodulation:
http://merck.praxis.md/bpm/bpmviewall.asp?page=CPM02AL306
----------
Lupus Organization Summary
http://www.lupus.org/education/brochures/medications.html
About 45% of SLE patients suffer gastrointestinal problems, including
nausea, weight loss, mild abdominal pain, and diarrhea. Severe
inflammation of the intestinal tract occurs in less than 5% of
patients and causes acute cramping, vomiting, diarrhea, and, rarely,
intestinal perforation, which can be life-threatening. Fluid retention
and swelling can cause intestinal obstruction, which is much less
serious but causes the same type of severe pain. Inflammation of the
pancreas can be caused by the disease and by corticosteroid therapy.
{note: Mobic does not fall in the corticosteroid family of drugs}
--------------
Search criteria:
Mobic website
PubMed
PDR website
Google search terms:
Mobic/meloxicam+pancreatitis/inflammation of the pancreas
Mobic/meloxicam+adverse reactions
Darvocet/piroxicam+pancreatitis
Darvocet/piroxicam+adverse reactions
I hope this is the information you're looking for, but if anything is
unclear, would you kindly post a clarification notice before rating my
answer. We would like for your experience at Google Answers to be a
satisfactory one and thanks for visiting us.
Best wishes,
V |
