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Q: adverse reactions to perscription mobic ( Answered 5 out of 5 stars,   3 Comments )
Subject: adverse reactions to perscription mobic
Category: Miscellaneous
Asked by: debs50-ga
List Price: $25.00
Posted: 03 Nov 2002 11:44 PST
Expires: 03 Dec 2002 11:44 PST
Question ID: 97429
Can Mobic cause pancreas inflammation.  

Can Mobic cause pancreas inflammation.
Subject: Re: adverse reactions to perscription mobic
Answered By: voila-ga on 03 Nov 2002 17:22 PST
Rated:5 out of 5 stars
Greetings debs50,

Thanks for your question on the medication Mobic {meloxicam} today.
I've taken the liberty of finding a wide range of information on this
drug at varying levels of understanding.  If you could please skip 
over the sections with which you are already familiar and ask for 
clarification if any of this information is unclear.

My first stop in locating your information was to try
Usually drug names have their own website categorized on the internet.
However, the manufactures of Mobic {Boehringer Ingelheim} has this 
drug listed under "mobictablet.


Mobic (meloxicam):


Physician's Desk Reference:

The following is a list of adverse drug reactions occurring in < 2% of
patients receiving MOBIC in clinical trials involving approximately
400 patients. Adverse reactions reported only in worldwide post-
marketing experience or the literature are shown in italics and are 
considered rare(< 0.1%).

Body as a Whole: allergic reaction, anaphylactoid reactions including
shock, face edema, fatigue, fever, hot flushes, malaise, syncope, 
weight decrease, weight increase Cardiovascular: angina pectoris, 
cardiac failure, hypertension, hypotension, myocardial infarction, 
vasculitis Central and Peripheral Nervous System: convulsions, 
paresthesia, tremor, vertigo Gastrointestinal: colitis, dry mouth, 
duodenal ulcer, eructation, esophagitis, gastric ulcer, gastritis, 
gastroesophageal reflux, gastrointestinal hemorrhage, hematemesis, 
hemorrhagic duodenal ulcer, hemorrhagic gastric ulcer, intestinal 
perforation, melena, pancreatitis, perforated duodenal ulcer, 
perforated gastric ulcer, stomatitis ulcerative Heart Rate and Rhythm:
arrhythmia, palpitation, tachycardia Hematologic: agranulocytosis, 
leukopenia, purpura, thrombocytopenia Liver and Biliary System: ALT 
increased, AST increased, bilirubinemia, GGT increased, hepatitis, 
jaundice, liver failure Metabolic and Nutritional: dehydration 
Psychiatric Disorders: abnormal dreaming, anxiety, appetite increased,
confusion, depression, nervousness, somnolence Respiratory: asthma, 
bronchospasm, dyspnea Skin and Appendages: alopecia, angioedema, 
bullous eruption, erythema multiforme, photosensitivity reaction, 
pruritus, Stevens-Johnson syndrome, sweating increased, toxic 
epidermal necrolysis, urticaria Special Senses: abnormal vision, 
conjunctivitis, taste perversion, tinnitus Urinary System:
 BUN increased, creatinine increased, hematuria, interstitial 
nephritis, renal failure.


Revised Product Summary {6/26/02}:"adverse+reactions"+"mobic"+"2002"&hl=en&ie=UTF-8


Mobic Indications:

What is Mobic used for?

Mobic is used to relieve the signs and symptoms of osteoarthritis in 

Who should not take Mobic?

You should not take Mobic if you have experienced asthma, hives, or 
allergic-type reactions after taking aspirin or other nonsteroidal 
anti-inflammatory drugs (NSAIDs). A few examples of other NSAIDs are 
ibuprofen, naproxen, diclofenac, nabumetone, and ketoprofen.

Mobic Systemic Information:


Pancreatitis is inflammation of the pancreas, a gland that lies behind
the stomach. The pancreas produces the hormones insulin and glucagon 
to control metabolism. It also produces other hormones and enzymes to
aid digestion of fats, proteins, and carbohydrates. The hormones and 
enzymes flow from the pancreas through the pancreatic duct into the 
upper part of the small intestine (duodenum).

Inflammation occurs when the digestive enzymes attack the pancreas. 
The inflammation may occur suddenly (acute pancreatitis) or develop 
over many years (chronic pancreatitis).




In relation to the above information, pancreatitis lies in the 'rare'
risk category for patients taking Mobic.  Therefore, with regard to 
your specific question "Does Mobic cause pancreas inflammation?" I 
would have to say an equivocal "no"; Mobic in and of itself does not 
cause pancreatitis, but any underlying conditions would need to be 
assessed by your physician.   Google Answers is in no way a substitute
for expert medical advice.

The reason I used the word 'equivocal' is because meloxicam is closely
related to the drug piroxicam in which a pancreatitis connection is 
cited in the literature.   Without proper critical review, I can't 
state with certainty that there are additional risk factors for those
taking piroxicam.  The following studies might be of interest to you 
in assessing the risks of NSAIDs, and piroxicam and meloxicam in 
particular.  Please feel free to discuss these studies with your 
doctor or a health professional.

From PubMed

Jick H, Derby LE, Garcia Rodriguez LA, Jick SS, Dean AD.

Nonsteroidal antiinflammatory drugs and certain rare, serious adverse
events: a cohort study.
Pharmacotherapy. 1993 May-Jun;13(3):212-7.
PMID: 8321735


Mallory A, Kern F.

Drug-induced pancreatitis.
Baillieres Clin Gastroenterol. 1988 Apr;2(2):293-307. Review.
PMID: 3044464


Haye OL.

Piroxicam and pancreatitis.
Ann Intern Med. 1986 Jun;104(6):895. No abstract available.
PMID: 3706949


{note, I had to register here to access this information but the 
entire abstract is only available to Lancet subscribers.}

The safety of cyclo-oxygenase 2 (COX-2) preferential inhibitors such 
as meloxicam is debated. We describe a patient who presented with 
bloody diarrhoea after 15 mg meloxicam daily for 10 days for 
osteoarthritis. The endoscopic and histological features were 
consistent with the diagnosis of ischaemic colitis. Symptoms and 
endoscopic lesions quickly regressed within 1 week of meloxicam 
withdrawal. There was no evidence of another cause of colonic 
ischaemia. We suggest that meloxicam might have intestinal toxic 
effects when taken in high doses, because of reduced COX-2
Service d'Hépato-Gastroentérologie, Laboratoire Central d'Anatomie et
de Cytologie Pathologiques, CHU Robert Debré, 51092 Reims Cedex, 
France (B Garcia MD, F Ramaholimihaso MD, Prof M-D Diebold MD, Prof G
Cadiot, Prof G Thiéfin MD)
Correspondence to: Prof Gérard Thiéfin (


Richard M Martin, Pipasha Biswas and Ronald D. Mann (Drug Safety 
Research Unit, Bursledon Hall, Southampton and School of Medicine, 
Faculty of Medicine and Biological Sciences, University of

The incidence of adverse events and risk factors for upper 
gastrointestinal disorders associated with meloxicam use amongst 19087
patients in general practice in England: cohort study.

Br.J.Clin.Pharmacol, 50(1),July 2000, 35-42.

Conclusion was that in the absence of gastrointestinal risk factors, 
incidence of GI disturbance was low. Such risk factors should be 
carefully reviewed prior to prescribing meloxicam.


Boehringer-Ingelheim News:

Boehringer Ingelheim continues its commitment to discovering and 
developing innovative therapeutics for treatment of chronic 
inflammatory diseases. A parenteral formulation of meloxicam for the 
initial treatment of painful inflammatory conditions was recently 
approved in Europe via a mutual recognition procedure and is now 
available in most European countries. Promising drug candidates in 
clinical development include inhibitors for cell adhesion molecules 
and cell signalling, such as LFA-1antagonists or p38 MAP kinase 
inhibitors, for the treatment of diseases such as rheumatoid
psoriasis and Crohn’s disease.


British Medical Association and the Royal Pharmaceutical Society of 
Great Britain:


Australia Drug Watch List:


Public Citizen Watch List:

Family: Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)

Reactions: Depression, paranoia, psychosis, confusion, anxiety

Notes: Probably more common with indomethacin (INDOCIN); one case of 
auditory hallucinations with celecoxib (CELEBREX)

Examples: Ibuprofen (MOTRIN); naproxen (NAPROSYN); meloxicam (MOBIC);
rofecoxib (VIOXX)


Immunotherapy and Immunomodulation:


Lupus Organization Summary

About 45% of SLE patients suffer gastrointestinal problems, including
nausea, weight loss, mild abdominal pain, and diarrhea. Severe 
inflammation of the intestinal tract occurs in less than 5% of 
patients and causes acute cramping, vomiting, diarrhea, and, rarely, 
intestinal perforation, which can be life-threatening. Fluid retention
and swelling can cause intestinal obstruction, which is much less 
serious but causes the same type of severe pain. Inflammation of the 
pancreas can be caused by the disease and by corticosteroid therapy.
{note:  Mobic does not fall in the corticosteroid family of drugs}


Search criteria:
Mobic website
PDR website

Google search terms:
Mobic/meloxicam+pancreatitis/inflammation of the pancreas
Mobic/meloxicam+adverse reactions
Darvocet/piroxicam+adverse reactions

I hope this is the information you're looking for, but if anything is
unclear, would you kindly post a clarification notice before rating my
answer.  We would like for your experience at Google Answers to be a 
satisfactory one and thanks for visiting us.

Best wishes,
debs50-ga rated this answer:5 out of 5 stars
Very good answer. Thank you

Subject: Re: adverse reactions to perscription mobic
From: researcher7-ga on 04 Nov 2002 04:30 PST
The above discussion is an excellent summation of known effects of the
pharmaceutical, mobic.  Several other aspects of your question may be
additionally addressed.

When asking a question about an adverse reaction by a patient to a
specific drug, it's important to know the health status of the person
asking the question.  It's also important to know what other
medications the patient, in question, is taking.

For example, while pancreatitis was a rarely observed side-effect in
the clinical evaluation of this medication, inflammation of the
pancreas might occur in a patient, while numerous medical disorders
and who is also taking numerous medications.

Unfortunately, many patients feel uncomfortable discussing medication
use with their physicians. Because of this, I always suggest to
patients, that should a drug question arise for them, they should pose
their concerns to their pharmacist for clarification.

Thank you for an excellent, thought-provoking question.

Good luck with your research for arthritis therapeutics.
Subject: Re: adverse reactions to perscription mobic
From: researcher7-ga on 04 Nov 2002 04:34 PST
correction of typo:

The correct phrase is: " with numerous medical disorders".
Subject: Re: adverse reactions to perscription mobic
From: voila-ga on 04 Nov 2002 08:53 PST
Gee, research7, thanks a lot!  The GA researchers try to take extra
special care when addressing medical questions.  And I almost used
'pharmacist' but changed the wording to read the all-emcompassing
'healthcare professional.'  Pharmacists do indeed have a wealth of
knowledge and are a physician's and a patient's best friend.

Sadly, my spacing went awry in my cut-and-paste job, so I beg debs50's
indulgence on that.  We appreciate any thoughtful comments that will
add to the discussion, so thanks for your participation and your kind


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