Hi there. I am looking for an overview of the pharmaceutical market,
the forces that are driving the sector example quest for manufacturing
excellence, lean manufacturing,regulatory compliance,generic
competition etc. The answer needs to include figures re growth rates
and if possible areas where pharma are spending money. Thank you!

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Clarification of Question by gill53-ga on 20 Jan 2003 13:05 PST

$75 works for me.

Hello Gill53, and thanks for a challenging question.  As one commenter
noted, there's an awful lot of material to cover here (regardless of
the price!), but I think I can provide a reasonable overview.


The pharmaceutical industry is a huge, rapidly changing area of
commerce that is responding to a number of key market, regulatory and
technological forces.
A summary of the scope of the industry, and some of the driving forces
are as follows:

Size of the industry:  Global sales of pharmaceuticals amounted to
$392 billion dollars in 2001 (this applies chiefly to "prescription"
drugs, although different countries have different definitions at work
here).  This represents a growth of 12% over sales in 2000, and makes
the pharmaceutical industry one of the largest sectors of the global
economy.  The industry also seems less prone to economic gyrations
than, say, the automobile or housing industries, because, regardless
of economic conditions, people continue to get sick, and many outlays
for pharmacuticals are the result of government programs and/or
private insurance expenditures.  The U.S. is the largest consumer of
pharmacuticals, accounting for about 50% of the global market. Japan
is the second largest country market; Europe (as a whole) is also a
sizable consumer of pharmaceuticals.

Major Players:  Like many global industries, pharmaceuticals are
undergoing a period of intense restructuring and consolidation. 
Leading companies include Pfizer, Merck and Bristo-Meyers-Squibb in
the U.S.; GlaxoSmithKline and AstraZeneca in the U.K.; and Novartis
and Aventis in Europe.

Products:  Antiulcerants (heartburn medicines) are the leading area of
pharmaceutical products, headed by blockbuster products such as
Prilosec and Lipitor.  Other categories that are large and growing
particularly rapidly (20% or more per year)include:  cholesterol and
triglyceride reducers, antipsychotics, oral antidiabetics, and
systemic antihistamines.  Some other categories, although not as large
commercially, are also growing rapidly.  This is especially true for
HIV therapeuticals and erectile dysfunction drugs like Viagra.

Market Drivers:  Several forces are giving direction to the
pharmaceuticals market:

--Demographics:  The aging of the population, especially in the U.S.,
creates an expanding demand for drugs related to menopause, diabetes,
cholesterol, arthritis, and other conditions of old age.  Emerging and
epidemic diseases (HIV, flu epidemics, West Nile virus, "mad cow"
disease) create a need and/or public expectation of a successful
pharmaceutical treatment.

--Patents:  An explosion of pharmaceutical innovation in the past few
decades has created scores of new, successful drug products.  Many of
the patents on these products are due to expire in the foreseeable
future.  When the patent on Prozac expired, the drug's sales plummeted
by 70% in just two months, in favor of a generic substitute.
 
--Advertising:  The use of direct-to-consumer advertising for
pharmaceutical products -- unheard of not that long ago in the U.S. --
is credited by many observers as having spurred a good deal of the
rapid growth in global pharmaceutical sales.


Technological drivers: This industry is heavily invested in R&D,
spending an estimated $30 billion in 2001.  New avenues of research --
biotechnology (genetic engineering), genomic research (unlocking the
genetic code to understand and treat disease), pharmacogenetics
(targeting specific drugs to individuals depending on their genetic
structure) -- are opening up new areas of drug development. 
Sophisticated diagnostic and testing technologies are reducing the
time needed to screen and evaluate new chemicals as preliminary
candidates for a new drug. For instance, many screening tests that
formerly involved exposing laboratory animals for a period of months,
can now be carried on cell cultures much more rapidly.

Information technology has not only enabled more focused research
efforts, but has tied development more closely to market demands, as
manufacturers make use of real-time feedback from doctors and
pharmacies to gauge what conditions consumers (i.e. patients) are
seeking treatments for.


Regulatory situation:  Bringing a new drug to market can take decades,
partly due to the long research and development time, and partly due
to regulatory clearance procedures imposed by government agencies.  In
the U.S., the Food And Drug Administration has greatly speeded up new
drug reviews in recent years.  Observers are mixed as to the value
gained.  On the one hand, companies can bring new drugs to market much
faster, reducing costs and bringing benefits to consumers in need of
new medicines.  On the other hand, there have been reports of an
increasing number of adverse reactions to new drugs, causing some to
assume that drugs are entering the market without adequate safety
screening.

----

I hope this meets your needs for a brief yet thorough overview.  I try
to give the best answers possible, but if you feel additional
information is needed, please post a "Request for Clarification"
before rating this answer.






Sources:

http://pubs.acs.org/cen/coverstory/8048/8048pharmaceutical.html
Pharma Overview

http://www.census.gov/cir/www/
Current Industrial Reports

Numerous off-line printed reports

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Request for Answer Clarification by gill53-ga on 21 Jan 2003 00:48 PST

Hi there. Thanks for that. Would you be able to point me in the right
direction so as I can do some further research on regulatory and lean
manufacturing drivers?
Thanks!

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Clarification of Answer by pafalafa-ga on 21 Jan 2003 09:19 PST

I'll be happy to provide some additional information.  It will take a
bit of time, though.  I hope to have a response for you
tomorrow....stay tuned!

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Clarification of Answer by pafalafa-ga on 21 Jan 2003 13:19 PST

Gill53,

Thanks for making your request so specific...it's a great help to me
in being able to follow up and meet your needs.  I'm going to suggest
here some general overview documents that are worth a look, along with
specific materials that address your request:


Overview of the pharmaceutical industry:

The annual report of the Pharmaceutical Research and Manufacturers of
America (PhRMA) is a must read.  It covers the basic economics of the
industry, recent advances, emerging trends in medicine and health
care, and regulatory and policy issues of importance to the industry,
both in the U.S. and around the world.

http://www.phrma.org/publications/publications/annualreport/2002/

The PhRMA site has a number of other publications as well that are
worth exploring, especially the Pharmaceutical Industry Primer 2001:

http://www.phrma.org/publications/publications/10.08.2001.528.cfm

and The PhRMA Industry Profile at:

http://www.phrma.org/publications/publications/profile02/index.cfm




Lean Manufacturing:

In my experience, the pharmaceutical industry is a bit more skittish
of lean manufacturing, six sigmas, and other "quality" trends than
most other manufacturing enterprises.  The reasons are twofold:

(1) the cost of manufacturing drugs is often only a small part of
overall industry costs, which can include huge outlays for R&D,
regulatory clearance, and marketing.  Profit margins in the
pharmaceutical are historically among the highest of any industry. 
Under these conditions, the economic incentive for trimming
manufacturing costs is not as keen as it might be in other sectors.

(2) drug manufacturers are traditionally loathe to tinker with a
production process that is working, fearing that *any* change to the
process – even one with the promise of significant cost savings –
might adversely impact the quality of the finished product.  If the
product is, say, paper towels, a temporary lapse in quality might be
worth the risk to achieve costs savings.  But when the product is a
medicine meant to save lives, a temporary lapse in quality could mean
disaster.

Having said that, drug companies are certainly not immune to economic
pressure, and have adopted a great many techniques aimed at achieving
lean manufacturing operations, ranging from enterprise-wide
information approaches, to increasing precision in supply chain
management, to tinkering with the fundamental chemistry of the
drug-manufacturing process itself .  I've included a few links and
dead-tree articles to give you some background here:

Validation of Enterprise-Wide Systems: Lessons From the Field
http://www.americanpharmaceuticalreview.com/past_articles_f.htm 
Enterprise resource planning in the pharmaceutical industry


Process Variability or Process Capability
http://www.americanpharmaceuticalreview.com/past_articles_f.htm
Statistical process control in the pharmaceutical industry

Emerging Science Issues in Pharmaceutical Manufacturing: Process
Analytical Technologies
http://www.fda.gov/ohrms/dockets/ac/01/briefing/3804b1_07_hussain/
An exploration of recent advances in science that are changing the
nature of  pharmaceutical manufacturing.

An article in Chemical Week magazine, "Drug Industry Cost Pressure
Could Benefit Chemical Firms" (6/19/02) covers factors in the industry
that are leading an increasing number of companies to look more
aggressively for cost savings through lean manufacturing and other
quality improvement approaches.  (Chemical Week articles can be
accessed online if you subscribe to their site at [
http://www.chemweek.com ].

A subsequent Chemical Week issue (9/18/02) has a special multi-article
section that covers, in much more detail, innovations in the
pharmaceutical industry that are leading to greater process
efficiencies.  The articles have  intriguing titles like "Chiral
chemistry is an essential pharma kit component" and "Breakthrough
process development."  The issue covers some of the main efficiency
improvements being pursued in drug manufacturing.


Regulations:

I'm not sure what's more complicated: pharmaceutical chemistry or
pharmaceutical regulation.  One can easily devote a lifetime trying to
understand all the nuances at work here, but a few sites attempt to
make sense out of the regulatory morass, both in the U.S. and
elsewhere around the world:

Once again, PhRMA should be one of your first stops.  Their "Issues"
page at:

http://www.phrma.org/issues/

includes links and write-ups on Bioterrorism, Direct-to-Consumer
Advertising, FDA Issues, Genomics, lawsuits, Intellectual Property,
Medicaid, Medicare, Prescription Drug Costs, Reimportation, Research &
Development, Scientific and Regulatory Affairs.  All of these are "hot
button" areas that are regulated or potentially subject to regulation,
and are active (and complex) drivers in the industry.

Chemical and Engineering News magazine has some good overview articles
on regulatory issues, and I believe these are available to the public
online:

FDA WALKS A FINE LINE
Agency tries to find the right balance between thoroughness and
efficiency in drug approval
http://pubs.acs.org/cen/coverstory/8048/8048pharmaceutical3.html

Long, Laborious Path To Drug Approval
http://pubs.acs.org/cen/coverstory/8048/8048pharmaceutical3A.html


FDA CONSOLIDATES DRUG REVIEW
http://pubs.acs.org/cen/topstory/8037/8037notw7.html

REGULATORY AFFAIRS
Drug industry relies on those who navigate the ground between
development and approval
http://pubs.acs.org/cen/employment/8048/8048regulatoryaffairs.html

								
Lastly, a conference of a few years ago has put a number of its
presentations online, mostly in the form of Powerpoint slides.  But it
is worth a look:

The Second Annual Pharmaceutical Industry Regulatory & Compliance
Summit:
http://www.pharmaregulation.com/agenda/index.html
								

I hope this is what you need, but if anything seems to be missing (or
if I've missed a target!), just let me know.

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Clarification of Answer by pafalafa-ga on 21 Jan 2003 19:06 PST

Sorry...there were a few more links I inadvertently omitted:

LEAN MANUFACTURING:

http://www.impletech.com/erp/vertical_mkts/medpharm_cs.htm

Case Study: Medical/Pharmaceutical - Global Pharm Inc.[Enterprise
Resource Planning system implementation]


REGULATIONS:

http://www.fda.gov/cder/present/dia-nice2000/dianice1/index.htm
Accelerating Drug Development:  Regulatory Initiatives in the USA
Author: Murray M. Lumpkin, M.D. 
Deputy Center Director 
Center for Drug Evaluation & Research 
US Food and Drug Administration 

http://www.fda.gov/cder/present/406bjw/index.htm
State of the U.S. Drug Regulatory System

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Clarification of Answer by pafalafa-ga on 18 Dec 2006 12:55 PST

I came across this list of biotechnology firms in the US, and thought
it would be of interest:


21st Century Biochemicals LLC	 http://www.21stcenturybio.com
454 Life Sciences	 http://www.454.com
ABBOTT Bioresearch Center (ABC)	 http://www.abbott.com/abbottbioresearch/
ABCAM, Inc.	 http://www.abcam.com
ABIOMED, Inc.	 http://www.abiomed.com
Absolute Science, Inc.	 http://www.absolutescience.com
Acambis, Inc.	 http://www.acambis.com
Accelerated Cure Project for Multiple Sclerosis	
Acceleron Pharma, Inc.	
Accovion Inc.	 http://www.accovion.com
ACOM* Healthcare	 http://www.acomhealthcare.com
ActivBiotics	 http://www.activbiotics.com
Acusphere	 http://www.acusphere.com
Addgene, Inc.	 http://www.addgene.com
AdipoGenix, Inc.	
Advanced Cell Technology	
Advanced Magnetics, Inc.	 http://www.advancedmagnetics.com
AdvanDx, Inc.	 http://www.advandx.com
Aeris Therapeutics, Inc.	 http://www.aerist.com
Aerotek	 http://www.aerotek.com
Agencourt Bioscience Corporation	 http://www.agencourt.com
Agilent	
Agrenetics	 http://www.agrenetics.com
Alantos Pharmaceuticals, Inc.	 http://www.alantos.com
Alexandria Real Estate Equities	 http://www.labspace.com
Alnylam Pharmaceuticals	 http://www.alnylam.com
ALPCO Diagnostics	
ALS Therapy Development Foundation	 http://www.als.net/alstdf/
ALTANA Research Institute	 http://www.ari.altanapharma.com
Altus Pharmaceuticals Inc.	 http://www.altus.com
Amaranth Bio Inc.	 http://www.amaranthbio.com
American Australian Association of New England	
American Integrated Biologics, Inc.	 http://www.aibiologics.com
Amgen, Inc.	 http://www.amgen.com
Ancora Pharmaceuticals, Inc.	
AniGenics Inc.	 http://www.anigenics.com
Anika Therapeutics, Inc.	 http://www.anikatherapeutics.com
Antigen Express, Inc.	 http://www.antigenexpress.com/
Antigenics	 http://www.antigenics.com
Aphios Corporation	 http://www.aphios.com
ApoConsult LLC	
Apple Computer, Inc.	 http://www.apple.com/scitech
Applied Risk Management, LLC	 http://www.arm-security.com
Apredica	
Archemix Corporation	 http://www.archemix.com
Ardais Corporation	 http://www.ardais.com
Ariad Pharmaceuticals, Inc.	 http://www.ariad.com
Ariston Pharmaceuticals, Inc.	 http://www.aristonpharma.com
ArQule, Inc.	 http://www.arqule.com
Arthur J. Gallagher & Company	 http://www.ajgnewengland.com
Associates of Cape Cod, Inc.	 http://www.acciusa.com
AstraZeneca R&D Boston	
http://http://www.astrazeneca-us.com/content/RD/northAmericanLocations/boston/
Athena Diagnostics, Inc.	
AVANT Immunotherapeutics, Inc.	 http://www.avantimmune.com
Avatar Pharmaceutical Services, Inc.	 http://www.avatarps.com
Avecia Biotechnology, Inc.	 http://www.avecia.com
AVEO Pharmaceuticals, Inc. (f/k/a GenPath Pharmaceuticals)	
http://www.aveopharma.com
Averion, Inc.	 http://www.averioninc.com
Azopax Therapeutics	 http://www.azopax.com
Babson Executive Education	 http://www.babson.edu/bee
BattelleCRO, Inc. (formerly CareStat	 http://www.BattelleCRO.com
Beth Israel Deaconess Medical Center	 http://www.bidmc.harvard.edu
BG Medicine, Inc.	 http://www.BG-Medicine.com
Bingham McCutchen LLP	 http://www.bingham.com
Bioactives	
Bio-Concept Laboratories	 http://www.bioconcept.com
Bioforce Solutions	 http://www.bioforcesolutions.com
Biogen Idec, Inc.	 http://www.biogenidec.com
BioHelix Corporation	
Biomatic Technologies, Inc.	 http://www.biomatic.com
Biomeasure, Incorporated	
BioMed 20/20 Technologies, Inc.	 http://www.biomed2020.com
Biomedical Research Models, Inc. (BRM)	 http://www.biomere.com
Biometrix Corporation	 http://www.biometrix.com
Bionaut Pharmaceuticals	 http://www.bionautpharma.com
BioPhysics Assay Laboratory, Inc.	 http://www.biopal.com
BioProcessors Corp.	 http://www.bioprocessors.com
Biopure Corporation	 http://www.biopure.com
Bioscience Valuation LLC	
BioSquare at Boston University Medical Center	 http://www.biosquare.org
BioTeam Paris Region	 http://www.bioteam.fr
BioTrove, Inc.	 http://www.biotrove.com
BioVentures Investors	 http://www.bioventuresinvestors.com
BioVest International, Inc.	 http://www.biovest.com
BioVex, Inc.	 http://www.biovex.com
Blue Cross Blue Shield of Massachusetts	 http://www.bluecrossma.com
Blue Hive	 http://www.blue-hive.com
Blue Sky Biotech, Inc.	 http://www.blueskybiotech.com
Boston Analytical	 http://www.bostonanalytical.com
Boston Biochem, Inc.	 http://www.bostonbiochem.com
Boston Biomedical Research Institute	 http://www.bbri.org
Boston Life Sciences, Inc.	 http://www.bostonlifesciences.com
Boston Properties	 http://www.bostonproperties.com
Bristol-Myers Squibb Medical Imaging	 http://www.bmsmi.com
British Consulate -General	 http://www.britainusa.com/boston
Bromberg & Sunstein, LLP	 http://www.bromsun.com
Caliper Life Sciences, Inc.	 http://www.caliperls.com
Cambrex Bioscience Hopkinton, Inc.	 http://www.cambrex.com
Cambria Biosciences LLC	 http://www.cambriabio.com
Cambridge Biomedical Career Program	 http://www.justastart.org/
Cambridge Biomedical Research Group, Inc.	 http://www.cambridgebiomedical.com
Canadian Consulate General	 http://www.dfait-maeci.gc.ca/~boston
Capital Advisors Group	 http://www.capitaladvisors.com
Capralogics, Inc.	 http://www.capralogics.com
Captains of Industry	 http://www.captainsofindustry.com
Cardinal Health	 http://www.cardinal.com/pts
Cardiovascular Clinical Studies, LLC	 http://www.ccstrials.com
Cato Research - Boston	 http://www.cato.com
CB Richard Ellis Whittier Partners	 http://www.cbrichardellis-ne.com
CBR Institute for Biomedical Research	 http://www.cbrinstitute.org
Celera Genomics	 http://www.celera.com
Cell Essentials, Inc	 http://www.cell-essentials.com
Cell NetwoRx LLC	
Cell Signaling Technology	 http://www.cellsignal.com
Cellicon Biotechnologies Inc.	
CereMedix, Inc.	 http://www.ceremedix.com
Cetek Corporation	
Charles River Laboratories	 http://www.criver.com
Chemic Laboratories, Inc.	 http://www.chemiclabs.com
Children's Hospital Boston, Intellectual Property Office	
http://www.childrenshospital.org/ipo
CIS - US, Inc.	 http://www.cisusinc.com
Clarkston Consulting	 http://www.clarkstonconsulting.com.
CleanRooms Magazine	
Clinical Assistance Programs, LLC	 http://www.captrials.com
Clinquest, Inc.	 http://www.clinquestinc.com
CNH Technologies, Inc.	 http://www.cnhtechnologies.com
Codexis, Inc.	 http://www.codexis.com
Codon Devices	
Cohesive Technologies, Inc.	 http://www.cohesivetech.com
Coley Pharmaceutical Group	 http://www.coleypharma.com
Collegium Pharmaceutical	 http://www.collegiumpharma.com
CombinatoRx, Inc.	 http://www.combinatorx.com
Comerica Bank/Technology & Life Sciences Division	 http://www.comerica.com
company	
Compound Therapeutics	 http://www.compoundtherapeutics.com/
CompuCyte Corporation	 http://www.compucyte.com
Comrise Technology, Inc.	 http://www.comrise.com
conduit Systems, Inc.	 http://www.conduitsystems.com
Confluent Surgical, Inc.	 http://www.confluentsurgical.com
Core2 Business Consulting, Inc.	 http://www.core2bc.com
Corning Incorporated	 http://www.corning.com/lifesciences
Correlagen, Inc.	 http://www.correlagen.com
Court Square Data Group	 http://www.csdg.com
Covance Inc.	 http://www.covance.com
Craven & Ober, Policy Strategists, LLC	 http://www.policystrategists.com
Critical Therapeutics, Inc.	 http://www.crtx.com
Cubist Pharmaceuticals, Inc.	 http://www.cubist.com
Curis, Inc.	 http://www.curis.com
Cyagra, Inc.	 http://www.cyagra.com
Cytel Inc.	 http://www.cytel.com
Cytomatrix, LLC	 http://www.cytomatrix.com
Cytonome, Inc.	 http://www.cytonome.com
CytRx Laboratories, Inc. (formerly Araios)	 http://www.cytrxlabs.com
Cytyc Corporation	 http://www.cytyc.com
D. Glass Associates, Inc.	 http://www.dglassassociates.com
Dacon Corporation	 http://www.dacon1.com
Daedalus Software, Inc.	 http://www.daedalussoftware.com
Dana Farber Cancer Institute	 http://www.dfci.harvard.edu
Decision Biomarkers	 http://www.decisionbiomarkers.com
Deloitte & Touche LLP	 http://www.us.deloitte.com
DePuy Biologics	
Domantis, Ltd.	 http://www.domantis.com
Dow Biopharmaceutical Contract and Manufacturing Services	 http://www.dowpharma.com
Drug Development Resources, Inc.	 http://www.ddres.com
Duane Morris LLP	
Dyax Corporation	 http://www.dyax.com
Dynogen Pharmaceuticals	 http://www.dynogen.com
Edwards Angell Palmer & Dodge LLP	 http://www.eapdlaw.com
Eisai Research Institute of Boston, Inc.	 http://www.eisai.co.jp
Elixir Pharmaceuticals, Inc.	 http://www.elixirpharm.com
Elucida Research LLC	
EMD Lexigen Research Center Corp.	 http://www.emdlexigen.com
ENANTA Pharmaceuticals, Inc.	 http://www.enanta.com
Endpoint Research LLC	 http://www.endpointresearch.com
Ensemble Discovery Corporation	 http://www.ensemblediscovery.com
Envirotainer, Inc.	 http://www.envirotainer.com
EnVivo Pharmaceuticals, Inc.	 http://www.envivopharma.com
Epic Therapeutics, Inc.	
http://http://www.baxterbiopharmasolutions.com/ddft/promaxx_tech.html
Epitome Biosystems	 http://www.epitomebiosystems.com
EpiVax Inc.	 http://www.epivax.com
EPIX Pharmaceuticals, Inc.	 http://www.epixpharma.com
Equis Corporation	 http://www.equiscorp.com
Ernst & Young	 http://www.ey.com
ETEX Corporation	 http://www.etexcorp.com
Exact Sciences Corporation	 http://www.exactsciences.com
Exalpha Biologicals, Inc	 http://www.exalpha.com
Expressive Constructs Inc.	 http://www.ecibiotech.com
Eyetech Pharmaceuticals, Inc.	 http://www.eyetk.com
Feinstein Kean Healthcare	 http://www.fkhealth.com
Fidelity Bioscience Group	
Finnegan, Henderson, Farabow, Garrett & Dunner, LLP	 http://www.finnegan.com
Fish & Richardson P.C.	 http://www.fr.com
Fisher Scientific International	 http://www.fishersci.com
Flagship Ventures	
Fleishman - Hillard	
FoldRx Pharmaceuticals	 http://www.foldrx.com
Foley & Lardner LLP	 http://www.foley.com
Foley Hoag LLP	 http://www.foleyhoag.com
Forest City Commercial GroupBoston Forest City Science + Technology
Group	 http://www.fceboston.com
Formatech, Inc.	 http://www.formatech.com
Foster Design Group, Inc.	 http://www.fosterdesign.com
Fox Relocation Management Corp.	 http://www.foxcorp.com
French Office for Science and Technology	
Fresenius Biotech North America, Inc.	 http://http://www.fresenius-ag.com/
Fulcrum Pharma Development Inc.	 http://www.fulcrumpharma.com
Fusion Medical Education, LLC	 http://www.fusion-meded.com
Galenea	 http://www.galenea.com
Gene Logic Inc.	 http://www.genelogic.com
Genetic Services, Inc.	 http://www.geneticservices.com
Genetix Pharmaceuticals, Inc.	 http://www.genetixpharm.com
Genfit Corp.	 http://www.genfit.com
Genitrix, LLC	 http://www.genitrix.com
Genomic Profiling Systems, Inc.	 http://www.genprosys.com
Genomics Collaborative	 http://www.genecoop.com
Genstruct, Inc.	 http://www.genstruct.com
GenVec, Inc.	 http://www.genvec.com
Genzyme Corporation	 http://www.genzyme.com
GlaxoSmithKline, Inc.	 http://www.gsk.com
Global Prior Art, Inc.	 http://www.globalpriorart.com
Gloucester Pharmaceuticals	 http://www.gloucesterpharma.com
GLSynthesis, Inc.	 http://www.glsynthesis.com
GlycoFi, Inc.	 http://www.glycofi.com
GlycoGenesys, Inc.	 http://www.glycogenesys.com
Goodwin Procter LLP	 http://www.goodwinprocter.com
GPC Biotech Inc.	 http://www.gpc-biotech.com
Green Mountain Antibodies	 http://www.greenmoab.com
GTC Biotherapeutics, Inc.	 http://www.gtc-bio.org
Gwathmey Inc.	 http://www.gwathmey.com
Hammond Hill LLC	 http://www.hammondhill.com
Harvard Clinical Research Institute (HCRI)	 http://www.hcri.harvard.edu
Harvard Extension School	 http://www.extension.harvard.edu/
Harvard Medical School	 http://www.hms.harvard.edu/otl
Health Advances, Inc.	 http://www.healthadvances.com
Helicos BioSciences Corporation	 http://www.helicosbio.com
HireMinds LLC	 http://www.hireminds.com
Histogenics Corporation	 http://www.histogenics.com
Hudson Scientific	 http://www.hudson.com/us
Hyaluron, Inc.	 http://www.hyaluron.com
Hydra Biosciences	 http://www.hydrabiosciences.com
Hypnion, Inc.	 http://www.hypnion.com
IBM Corporation	 http://www.ibm.com
ID Biomedical	 http://www.idbiomedical.com
Idenix Pharmaceuticals, Inc.	 http://www.idenix.com
Idera Pharmaceuticals	 http://www.iderapharma.com
IDIS	 http://www.idispharma.com
Immerge BioTherapeutics, Inc.	 http://www.immergebt.com
Immunetics, Inc.	 http://www.immunetics.com
ImmunoGen, Inc.	 http://www.immunogen.com
IMPACT Technology Consultants	 http://www.impact-tc.com
Indevus Pharmaceuticals, Inc.	 http://www.indevus.com
Indiana Centers for Applied Protein Sciences (INCAPS)	 http://www.indianacaps.com
Indigene Pharmaceuticals, Inc.	 http://www.indigenepharma.com
Infinity Pharmaceuticals, Inc.	 http://www.ipi.com
InnoCentive	 http://www.innocentive.com
Innovation Norway	
Inotek Pharmaceuticals Corporation	 http://www.inotekcorp.com
Intelligent Medical Devices, Inc.	 http://www.intelligentmd.com
Intercytex Ltd.	 http://www.intercytex.com
Interleukin Genetics, Inc.	 http://www.ilgenetics.com
International Biotechnology Investment Corp.	
Invest Northern Ireland	 http://www.investni.com
Invitrogen Corporation	 http://www.invitrogen.com
IQuum, Inc.	 http://www.IQuum.com
J. Calnan & Associates Inc.	
JETRO (Japan External Trade Organization)	 http://www.Jetro.go.jp
Johnson Matthey Pharma Services	 http://www.jmpharmaservices.com
Kard Scientific	 http://www.kardscientific.com
Keel Pharmaceuticals	
Keystone Partners	 http://www.keystonepartners.net
Kforce Scientific and Clinical Research Group	 http://www.kforce.com
Kirkpatrick & Lockhart Nicholson Graham LLP	 http://www.klng.com
L.E.K. Consulting LLC	 http://www.lek.com
LabPros, Inc.	 http://www.labprosinc.com
LaVoie Strategic Communications Group, Inc.	 http://www.lavoiegroup.com
LCT Biopharma, Inc.	 http://www.lctbiopharma.com
Levin & Company	 http://www.levinandcompany.com
Lex Company	
Life Science Insights	 http://www.life-science-insights.com
Link Medicine Corporation	
LNR Property Corporation	 http://www.lnrproperty.com
Lonza Biologics, Inc.	 http://www.lonzabiologics.com
Lyme Properties, LLC	 http://www.lymeproperties.com/content.html
M Squared Consulting Inc.	 http://www.msquared.com
Mabbett & Associates Inc.	
MacDougall Biomedical Communications, Inc.	 http://www.macbiocom.com
MacroChem Corporation	 http://www.macrochem.com
MannKind BioPharmaceuticals	 http://www.mannkindcorp.com
Marinus Pharmaceuticals, Inc.	 http://www.marinuspharma.com
Marsh Inc.	 http://www.marsh.com
Massachusetts Biomedical Initiatives (MBI)	 http://www.massbiomed.org
Massachusetts College of Pharmacy & Health Sciences	 http://www.mcphs.edu
Massachusetts Institute of Technology	 http://http://web.mit.edu
Massachusetts Office of International Trade and Investment, State
Transportation Building	 http://www.mass.gov/moiti
Matritech Inc.	 http://www.matritech.com
Maxiom Consulting Group	 http://www.MaxiomGroup.Com
MaxThera Inc.	
MBL International	 http://www.mblintl.com
McDermott Will & Emery LLP	 http://www.mwe.com
MedImmune Inc.	
MedPanel, Inc	 http://www.medpanel.com
MedSafe, Inc.	 http://www.medsafe.com
Merck & Co., Inc.	 http://www.merck.com
Mercury Computer Systems	 http://www.lifesciences.mc.com
Mercury Therapeutics, Inc.	
Meredith & Grew Inc.	
Merrimack Pharmaceuticals, Inc.	 http://www.merrimackpharma.com
Mersana Therapeutics	
Metabolix, Inc.	 http://www.metabolix.com
MetriGenix Corporation	 http://www.metrigenix.com
MGI Pharma Biologics, Inc.	 http://www.mgipharma.com
Microbia, Inc.	 http://www.microbia.com
Microbiotix, Inc.	 http://www.microbiotix.com
MicroCHIPS, Inc.	 http://www.mchips.com
MicroTest Laboratories (MTL), Inc.	 http://www.microtestlabs.com
Millennium Pharmaceuticals, Inc.	 http://www.millennium.com
Millipore Corporation	 http://www.millipore.com
Minerva Biotechnologies Corp.	
Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C.	
Modular Genetics, Inc.	 http://www.modulargenetics.com
Molecular Insight Pharmaceuticals, Inc.	 http://www.molecularinsight.com
Momenta Pharmaceuticals, Inc.	 http://www.momentapharma.com
Mouse Specifics, Inc.	 http://www.mousespecifics.com
MPM Capital	 http://www.mpmcapital.com
NAI Hunneman Commercial Co.	 http://www.naihunneman.com
Nanobiosym Inc.	
Nantero, Inc.	 http://www.nantero.com
Needham & Co., Inc.	 http://www.needhamco.com
Neurogen Corp.	 http://www.neurogen.com
Neurotech USA, Inc.	 http://www.neurotech.fr
New England Healthcare Institute	 http://www.nehi.net
New England Peptide, Inc.	 http://www.newenglandpeptide.com
New England Testing Laboratory, Inc.	 http://www.newenglandtesting.com
New World Laboratories	 http://www.NewWorldLabs.Com
NitroMed, Inc.	 http://www.nitromed.com
Nixon Peabody LLP	 http://www.nixonpeabody.com
Northeastern University	 http://www.neu.edu
Novartis Institutes for BioMedical Research, Inc.	 http://www.nibr.novartis.com
NovoBiotic Pharmaceuticals	 http://www.novobiotic.com
Nuclea Biomarkers LLC	
NUCRYST Pharmaceuticals Corp.	 http://www.nucryst.com
Nutter McClennen & Fish, LLP	 http://www.nutter.com
OmniGene Bioproducts, Inc.	 http://www.omnigenebioproducts.com
Oncogene Science Diagnostics	 http://www.oncogene.com
One Cell Systems, Inc.	 http://www.onecell.com
Organogenesis, Inc.	 http://www.organogenesis.com
Organon Research Center USA	 http://www.organon.com
Oscient Pharmaceuticals	 http://www.oscient.com
Osmetech, Inc.	 http://www.osmetech.com
Oxford Bioscience Partners	 http://www.oxbio.com
Oxford Finance Corporation	 http://www.oxfordfinance.com
OXiGENE, Inc.	 http://www.oxigene.com
Oxxon Therapeutics Inc.	 http://www.oxti.com
P. P. Manufacturing Corporation	 
P.A. Technologies	
PA Consulting Group	 http://www.paconsulting.com
Panacea Clinical Research	 http://www.panacea.org
Panacos	 http://www.panacos.com
Parallel Solutions, Inc.	 http://www.parallelsolutionsinc.com
Paratek Pharmaceuticals, Inc.	 http://www.paratekpharm.com
PAREXEL International Corp.	 http://www.PAREXEL.com
Partners Healthcare System, Inc.	 http://www.partners.org
Peptimmune, Inc.	 http://www.peptimmune.com
Pervasis Therapeutics, Inc.	 http://www.pervasistx.com
www.pervasistx.com www.pervasistx.com www.pervasistx.com
www.pervasistx.com
Pfizer, Inc.- Research Technology Center	 http://www.pfizerrtc.com
Pharma Bio-Research USA Inc.	 http://www.pbr.nl
PharmaMar USA Inc.	 http://www.pharmamar.com
PharmaPros Corporation	 http://www.pharmapros.com
Phase Forward, Inc.	 http://www.phaseforward.com
Phasex Corporation	
Phillips	 http://www.pdsearch.com
PHT Corporation	
Phylogix, Inc.	 http://www.phylogix.com
Phylonix Pharmaceuticals, Inc.	 http://www.phylonix.com
Pixel Bridge Inc.	 http://www.pixelbridge.com
Point Therapeutics Inc.	 http://www.pther.com
Polaris Venture Partners	 http://www.polarisventures.com
PolyOrg, Inc.	 http://www.polyorginc.com
PPD, Inc.	 http://www.ppdi.com
PRAECIS Pharmaceuticals, Inc.	 http://www.praecis.com
Predix Pharmaceuticals, Inc.	 http://www.predixpharm.com
Pressure BioSciences, Inc.	 http://www.pressurebiosciences.com
Prestige Executive Search Corporation	 http://www.prestigeesc.com
PricewaterhouseCoopers LLP	 http://www.pwc.com
Primera Biosystems	
Produce Safety Solutions, Inc.	 http://www.producesafetysolutions.com
PROMETRIKA	 http://www.prometrika.com
Pro-Motions, Inc.	 http://www.pro-motions.com
Pro-Pharmaceuticals, Inc.	 http://www.pro-pharmaceuticals.com
Protein Forest, Inc.	 http://www.proteinforest.com
Proteome Systems	 http://www.proteomesystems.com
QCB	 http://www.qcb.com
Quebec Delegation	 http://www.bioquebec.com
Queensland, Australia Trade & Investment Office	 http://www.sd.qld.gov.au
QuickSTAT - A division of Quick International Courier	 http://www.qicstat.com
Quintiles Transnational Corp.	 http://www.quintiles.com
Radius (formerly Nuvios)	 http://www.radiuspharm.com
Randstad	 http://www.us.randstad.com
Randstad (old)	 http://www.techspec.com
RDW Group Inc.	
Regis College	 http://www.regiscollege.edu
RenaMed Biologics	
Repligen Corporation	 http://www.repligen.com
RiboNovix, Inc.	 http://www.ribonovix.com
Rib-X Pharmaceutical, Inc.	 http://www.rib-x.com
Ricerca Biosciences LLC	
Ropes & Gray	 http://www.ropesgray.com
Ross Systems	 http://www.rossinc.com
Sanofi Aventis Pharmaceuticals	 http://www.sanofi-aventis.com
Saoirse Corporation	 http://www.saoirse.com
SBH Sciences, Inc.	 http://www.SBHSciences.com
SBR Pharmaceuticals Corp.	
Scimitar Equity Research, Inc.	 http://www.scimitarequity.com
Scion Pharmaceuticals, Inc.	 http://www.scionpharma.com
Scottish Development International	 http://www.scottishdevelopmentinternational.com
Seahorse Bioscience	 http://www.seahorsebioscience.com
Securitas - Pinkerton Consulting & Investigations	 http://www.ci-pinkerton.com
SelectX Pharmaceuticals, Inc.	 http://www.selectxpharm.com
SemanTx Life Sciences Inc.	
Sention	 http://www.sentionpharma.com
Sepracor Inc.	 http://www.sepracor.com
Serono, Inc.	 http://www.seronousa.com
Shire Pharmaceuticals	 http://www.shire.com
Signet Laboratories, Inc.	 http://www.signetlabs.com
Silicon Valley Bank	 http://www.svb.com
Sirtris Pharmaceuticals	 http://www.sirtrispharma.com
Spanish Biotechnology Association	 http://www.SpanishBiotech.Org
Spaulding & Slye	 http://www.spauldslye.com
Spherics, Inc.	 http://www.spherics.com
State Street Bank & Trust Co., High Technology Group	 http://www.statestreet.com
Straumann	 http://www.straumann.com
Stryker Biotech	 http://www.op1.com
Suffolk University	
Sullivan Insurance Group	 http://www.sullivangroup.com
Surface Logix, Inc.	 http://www.surfacelogix.com
Synta Pharmaceuticals Corp.	 http://www.syntapharma.com
Syntonix Pharmaceuticals, Inc.	 http://www.syntnx.com
Talent Capital Group	 http://www.talentcapitalgroup.com
Techmark Security Integration Inc	 http://www.techmarksecurityinc.com
Techno Venture Management	 http://www.tvmvc.com
Technology Management Corporation	 http://www.tmcrecycles.com
TEI Biosciences, Inc.	 http://www.teibio.com
Tepha, Inc	 http://www.tepha.com
Tepnel LifeCodes Corporation	 http://www.tepnellifecodes.com
Teranode Corporation	
Tessella Inc.	 http://www.tessella.com/Services/Sector/LifeSciences.htm
TGA Sciences, Inc.	 http://www.tgasciences.com
The Brigham and Women's Hospital	 http://www.bwh.partners.org
The Forsyth Institute	 http://www.forsyth.org
The Frankel Group, Inc.	 http://www.frankel-group.com
The GI Company	 http://www.thegicompany.com
The Jackson Laboratory	
The Richmond Group, Inc.	 http://www.therichmondgroup.org
Therion Biologics Corp.	 http://www.therionbio.com
Thermo Electron Corporation	 http://www.thermo.com
Thrasos Therapeutics	
Tissue Regeneration, Inc.	 http://www.tissueregen.com
TolerRx Inc.	 http://www.tolerrx.com
Total ReCord Inc.	
Toxikon Corporation	 http://www.toxikon.com
Trammell Crow Company	 http://www.trammellcrow.com
TransForm Pharmaceuticals, Inc.	 http://www.transformpharma.com
TransMolecular Inc.	
Transport Pharmaceuticals	
Trine Pharmaceuticals, Inc.	 http://www.trinepharma.com
Trinet	
Tufts University	 http://www.tufts.edu/vet/faculty_research
Turner Construction Company	 http://www.turnerconstruction.com
U.S. Genomics, Inc.	 http://www.usgenomics.com
Unither Pharmaceuticals, Inc.	 http://www.unither.com
University of Connecticut Technology Incubation Program	
University of Massachusetts	 http://www.massachusetts.edu
University of Massachusetts Medical Center Office of Technology
Transfer	 http://www.umassmed.edu
Vaccine Technologies, Inc.	
Verax Biomedical Incorporated	 http://www.veraxbiomedical.com
Versal Technologies, Inc.	 http://www.versal.com
Vertex Pharmaceuticals Inc.	 http://www.vrtx.com
ViaCell, Inc.	 http://www.viacell.com
VICAM, L.P.	 http://www.vicam.com
Vienna Business Agency	 http://www.vba.at
VisEn Medical	 http://www.visenmedical.com
Waterview Information Technology	 http://www.waterviewIT.com
Whitehead Institute	 http://www.wi.mit.edu
William Gallagher Associates	 http://www.wgains.com
Wilmer Cutler Pickering Hale and Dorr LLP	 http://www.wilmerhale.com
Wolf Greenfield & Sacks	 http://www.wolfgreenfield.com
Wolfe Laboratories, Inc.	 http://www.wolfelabs.com
Worcester Polytechnic Institute	 http://www.wpi.edu
WorldCare Clinical Trials, Inc.	 http://www.worldcareclinical.com
Wyeth Pharmaceuticals and Research Headquarters	 http://www.wyeth.com
Xanthus Life Sciences, Inc.	 http://www.xanthus.com
Xcellerex, Inc.	 http://www.xcellerex.com
Xemplar Pharmaceuticals, LLC	 http://www.xemplarpharm.com
Zapaq, Inc.	
Zelos Therapeutics	 http://www.zelostherapeutics.com
ZIOPHARM, Inc.	 http://www.ziopharm.com
ZymeQuest, Inc.	 http://www.zymequest.com

Hi -

You may want to consider upping the price point of your question to
the $75+ range due to the breadth of what you're requiring.

jbf777-ga
GA Researcher

You can check:
www.dsm.ru/old/news/ims_1100.pdf --> worldwide pharma market 2000

Do not forget to visit: http://open.imshealth.com/ (a very well-known
provider of medicines sales data). Some general snapshots are free.
You also can buy selected reports from open IMSHealth.

Check also this link: http://open.imshealth.com/download/sep2002.pdf

An intersting link from Bioscorpio: http://www.bioscorpio.com/
Click on the different medical conditions/diseases/therapeutic areas
in the left column in order to get a brief snapshot of the US market
related to that condition/therapeutic area.

Regards,
Tom