Google Answers Logo
View Question
Q: fertility in women with Down's Syndrome ( Answered 5 out of 5 stars,   1 Comment )
Subject: fertility in women with Down's Syndrome
Category: Science
Asked by: lullu-ga
List Price: $10.00
Posted: 14 Feb 2004 10:48 PST
Expires: 15 Mar 2004 10:48 PST
Question ID: 306781
fertility rates are reduced in people with Downs Syndrome.i am looking
for an up-to date article about this topic
Subject: Re: fertility in women with Down's Syndrome
Answered By: crabcakes-ga on 14 Feb 2004 18:45 PST
Rated:5 out of 5 stars
Hello lullu,

?Only 24 women with Down's syndrome have been reported to have had a
child, and no men with Down's syndrome to have done so (Jagiello,
1981).? (Scroll a little more than halfway down the page)
Healthy Baby

National Down Syndrome Society: ?Approximately 50 percent of women
with Down syndrome are fertile. Between 35 and 50 percent of children
born to mothers with Down syndrome will have Trisomy 21 or other
developmental disabilities.? Regarding men with Down Syndrome, few
studies have been done, but, The NDSS says this of men ?It does seem
clear that, in general, men with Down syndrome have a significantly
lower overall fertility rate than that of other men of comparable

?The chance of a woman with Down's Syndrome having a baby with Down's
Syndrome is theoretically 50%. There is one documented instance of
fertility in a male with Down's Syndrome; the mother also had Down's
Syndrome. The pregnancy miscarried about half-way through.?
National Institute on Developmental Delays

In this study, by Rosa Maria Cento, Letizia Ragusa, Caterina Proto,
Antonino Alberti, Gaetano Fiore, Fabio Colabucci, ovarian function was
found to be impaired in women with Down Syndrome, due to   ovaries
that were insensitive to FSH (Follicle stimulating hormone). Journal
of Human Reproduction

?With rare exceptions, men with Down syndrome cannot father a child.
In any pregnancy, a woman with Down syndrome has a 50-50 chance of
conceiving a child with Down syndrome, but many affected fetuses are
March of Dimes

BioMedCentral: ?Although a small percentage of women with Down's
syndrome do not menstruate, the vast majority of women with
developmental disabilities have regular menstrual cycles, comparable
to women in the general population? Allison A Brown BA and Carol J
Gill PhD

A WHO document states ?Between 65% and 80% of women with Down syndrome
have regular menstrual cycles, while 15 to 20% have never

From the University of Iowa Hospitals, an abstract by Don C. Van Dyke,
MD, Dianne M. McBrien, MD, Andrea Sherbondy, MD, ?Women have impaired
but still significant fertility: a number of reviews document women
with Down syndrome carrying pregnancy to term and delivering infants
with and without Down syndrome (Bovicelli et al, 1982; Rani et al,
1990)? Many babies born to moms with Down Syndrome are of low birth
weight, and may be born prematurely. See Table 5 for a chart
displaying results of births to Down Syndrome moms.

?Females with Down syndrome are fertile; males are sterile. Females
with Down syndrome have a 50% chance of having children with Down
syndrome. Identical twins with Down syndrome will both be affected. In
cases of fraternal twins, usually one twin is not affected?
Biomechanical management of children and adolescents with down
syndrome: proper diagnosis of biomechanical abnormalities allows for
more effective treatment of this condition. (Biomechanics &
April-May, 2003, by Mark A. Caselli

Research on fertility in women with Down Syndrome is very limited. 
Increased risk of thyroid disease, coupled with decreased ovarian
performance, reduce fertility in these women. Apart from natural
factors, many families of women with Down?s provide means of birth
control (Oral contraceptives, tubal ligations) to prevent unwanted

I hope this is the information you were seeking. If any part of my
answer is unclear, please request an Answer Clarification, before
rating. This will allow me to assist you further, if possible.


Search Terms
Fertility + ?women with Down?s?
Pregnancy + ?women with down?s?
lullu-ga rated this answer:5 out of 5 stars
thanks for the v.helpful & speedy reply

Subject: Re: fertility in women with Down's Syndrome
From: crabcakes-ga on 15 Feb 2004 07:18 PST
Thank you for the 5 stars! 

Important Disclaimer: Answers and comments provided on Google Answers are general information, and are not intended to substitute for informed professional medical, psychiatric, psychological, tax, legal, investment, accounting, or other professional advice. Google does not endorse, and expressly disclaims liability for any product, manufacturer, distributor, service or service provider mentioned or any opinion expressed in answers or comments. Please read carefully the Google Answers Terms of Service.

If you feel that you have found inappropriate content, please let us know by emailing us at with the question ID listed above. Thank you.
Search Google Answers for
Google Answers  

Google Home - Answers FAQ - Terms of Service - Privacy Policy