Request for Question Clarification by
tlspiegel-ga
on
21 Jan 2005 22:28 PST
Hi mcneill420,
Does this information answer your question? If so please post a
clarification asking me to post in the answer box.
http://www.erowid.org/chemicals/lsd/lsd_myth1.shtml
"There is an often circulated myth that once you have taken LSD, it
remains in your body forever. The main thing that keeps these rumors
circulating the is fact that some people (though very few) experience
"flashbacks" (generally within a few months after a hallucinogenic
experience). It is generally accepted, however, that these flashbacks
are not the result of lsd remaining in the system.
LSD is almost entirely metabolized within a day after ingestion. Since
the half-life of LSD is only a few hours, only a very small amount of
LSD remains even at the end of the trip, and this is excreted in the
urine. All traces are undetectable after several days and are
certainly gone entirely within a couple of weeks.
It has long been reported that LSD is fully metabolized almost
immediately after ingestion. This was based on research done in the
50's and 60s which used instruments not sensitive enough to detect the
extremely small amounts of the chemical. More recent research shows
that LSD's metabolism takes several hours and its peak plasma levels
occur at around 3-4 hours after ingestion.
From: "Measurement of lysergic acid diethylamide (LSD) in human plasma
by gas chromatography/negative ion chemical ionization mass
spectrometry." Papac DL, Folts RL , J.Anal. Toxicol., 14, 189-190
(1990)
In a volunteer given about 70 ug, the apparent plasma half-life of LSD
is 5.1 hr. The peak plasma concentration of 1.9 ng/mL occurred 3 hr
after administration.
From LSD My Problem Child, by Albert Hofmann, 1969
The concentration of LSD in the various organs attains maximum values
10 to 15 minutes after injection, then falls off swiftly. The small
intestine, in which the concentration attains the maximum within two
hours, constitutes an exception. The elimination of LSD is conducted
for the most part (up to 80%) through the instestine via liver and
bile. Only 1 to 10 percent of the elimination product exists as
unaltered LSD; the remainder is made up of various transformation
products.
From Psychedelics Encyclopedia :
LSD is a very curious chemical. When given by injection, it disappears
rapidly from the blood. It can be observed when tagged with Carbon 14
in all the tissues, particularly the liver, spleen, kidnes, and
adrenal glands. The concentration found in the brain is lower than in
any other organ -- being only about 0.01 percent of the administered
dose. [...]
LSD is highly active when administered orally, absorbed through mucous
membranes r through the skin, and is almost completely absorbed by the
gastrointestinal tract. Concentrations in the organs reach peak values
after only ten to fifteen minutes; then they decrease very rapidly.
[...] Some 80 percent of injested LSD is excreted via the liver, bile
system and intestinal tract, with only about 8 percent appearing in
uring. After two hours, only 1 to 10 percent is still present in the
form of unchanged LSD; the rest consists of water soluble metabolites
-- such as 2-oxo-2,3-dihydro-LSD -- which do not possess any LSD-type
influence on the central nervous system.
Psychic effects of LSD reach their peak about one to three hours
following ingestion, when much of the substance has disappeared from
the body's major organs, including the brain, though measurable
amounts persist in the blood and brain for about eight hours.
From the DEA Web Site :
LSD is absorbed easily from the gastrointestinal tract, and rapidly
reaches a high concentration in the blood. It is circulated throughout
the body and, subsequently, to the brain. LSD is metabolized in the
liver and is excreted in the urine in about 24 hours.
From Pharmacotheon :
The drug is almost completely eliminated from the body before the peak
effects begin, suggesting that it acts as a sort of catalyst, inducing
neurochemical changes which subsequently result in the entheogenic
experience. Only about 1-10% of injected LSD is excreted unaltered,
the remainder as a variety of degradation products."
=========
From Psychedelic Drugs Reconsidered :
The half-life of LSD in blood plasma is about two hours.
http://en.wikipedia.org/wiki/LSD
"LSD's primary effects normally last from 6 to 12 hours. One
characteristic feature of LSD is that with higher doses, the intensity
of the experience increases, but not the duration. It is typical for a
user of LSD to be unable to sleep restfully until at least 12 hours
have passed, and they do not feel completely "back to normal" until
after getting one or two full nights of restful sleep, although they
will exhibit no outward signs of impairment after the drug has worn
off.
LSD has an extremely short half life in the body. Most of the drug's
already minuscule dose is eliminated before the trip is even over,
suggesting that LSD triggers some sort of neurochemical cascade rather
than acting directly to produce its effects."
==========
Best regards,
tlspiegel
