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Q: High Histamine Levels ( Answered,   1 Comment )
Subject: High Histamine Levels
Category: Health > Medicine
Asked by: arek-ga
List Price: $5.00
Posted: 07 Feb 2005 23:38 PST
Expires: 09 Mar 2005 23:38 PST
Question ID: 470861
I have a high histamine level, is there any medicines to normalize or
block histamine. Thank you
Subject: Re: High Histamine Levels
Answered By: crabcakes-ga on 08 Feb 2005 11:34 PST
Hello arek,

  You don?t tell why you have a high histamine. Histamine levels can
become elevated for many reasons,and are usually temporary. Anything
recommended for lowering your level must be run by your physician.
Drug interactions can be problematic and even fatal in persons with an
elevated histamine, so please check before attempting to treat

  Allergies, surgical procedures, parasitic infections (real parasitic
infections such as those contracted from eating raw fish), certain
fish and shellfish, fermented foods, wines, salamis, etc. can cause an
elevated histamine.

?In humans, histamine (-imidazole ethylamine) is the most important
mediator and is mostly found in the initial phase of an anaphylactic
reaction ("immediate type" allergy). Histamine is produced by the
enzymatic decarboxylation of histidine. In the organism, histamine is
present in nearly all tissues, and it is mainly stored in the
metachromatic granules of mast cells and the basophilic leukocytes. It
is present in an inactive bound form and is released only as required.
Histamine acts predominantly on smooth muscle and blood vessels. In
humans, it is responsible for the broncho-constriction occurring
during the acute phase. In the vessels, its constrictive effect is
limited to the venula, whereas aterioles are dilated. Furthermore,
histamine causes a contraction of the cells of the vascular
endothelium and increases the vascular permeability, thereby allowing
higher-molecular substances to escape into the tissue?

?The HACCP information and prior supplier agreements with the sushi operation
should provide controls to prevent potential food safety hazards due
to parasites in certain raw
fish, elevated histamine levels in certain fish, and other seafood safety concerns?

?Symptoms of increased histamine release include impurities
(characteristically produced by bathing or showering), heartburn, acid
eructation, peptic ulcer, small bowel hypermotility, flushing and
angioneurotic edema.?

Reference Ranges
Urine Histamine: < 0.8 umoles/day Urine 1-Methyl-histamine: < 1.5 umoles/day
Blood Histamine: < 0.8 umoles/litre Blood 1-Methyl-histamine < 0.8 umoles/litre

The diet must be followed for 24 hours prior to and also during the
course of urine collection.
Avoid the following:
Fruit: Bananas, canned and fresh pineapple, plum, grapes, kiwifruit,
avocado, cherries, blueberries, raspberries, strawberries,
blackcurrants, oranges, guava, mango, passionfruit, dried fruit.
Jams:All except apricot.
Vegetables:Tomatoes, mushrooms, spinach, broccoli, brussel sprouts,
cauliflower, eggplant, broadbeans, pickled vegetables eg sauerkraut.
Nuts &Seeds: All including peanut butter and tahini
Dairy:All cheeses and cheese spreads, yoghurt flavoured with nuts,
muesli containing nuts or above fruits, chocolate yogo, banana
strawberry and chocolate flavoured milk, fruit smoothies.
Fish & Seafood: All including canned, fried and salted fish and seafood.
Chocolate:All forms including Cocoa and Milo.
Processed Meats: All including devon, salami, sausages, ham, chicken
loaf, turkey loaf.
Condiments:All chutneys and also malted or coloured vinegar,
mayonnaise & tartare sauce.
Fermented Foods: Yeast extracts eg Marmite, Vegemite, fish paste, fish
sauce, soy sauce, meat gravy.
Drinks:All wine and beer (all fermented beverages). Juices of all
fruit listed above.

You could help decrease histamine levels by eating foods that contain
methionine, an essential amino acid. Foods such as  ?sunflower seeds,
beef, eggs, cottage cheese, chicken, fish, pork, liver, sardines,
yogurt, pumpkin seeds, sesame seeds, and lentils? are alleged to lower
histamine levels, naturally.

Benadryl and other over the counter anti-histamines are often used
when histamine is released by mast cells (specialized white cells) in
reaction to an allergen.  ?Although there is always some histamine in
your body, a mosquito bite (for example), causes your body to release
more histamine in the area of the bite, making your skin red and
itchy. In extreme cases, histamine levels in someone who is allergic
to a bee sting or a particular food like strawberries can be elevated
so high that it causes anaphylactic shock and possibly death.
Adrenaline (Epinephrine) is the only chemical that can quickly
eliminate histamine in a person. So called "antihistamines" like
Benadryl only work to block some of your body's histamine receptors
(relieving some histamine related symptoms), they do not remove
histamine. If you do go into anaphylactic shock (where your organs
essentially shut down), it is essential that you are injected with
adrenaline immediately to counteract the dangerously high histamine
level and prevent death.?

?High histamine levels can be gradually reduced over time if the cause
of the "allergic" (autoimmune) reaction can be found. In my case it
was determined that I had trouble metabolizing sulfur (contained in
many foods) and had an excess of a chemical called histadine which is
also contained in many foods, especially breads. The sulfur and
histadine in the foods I ate caused my body to produce large
quantities of histamine. This isn't really an allergic reaction in the
typical sense. Tomatoes, wheat, milk and citrus fruits all contain
high quantities of sulfur which caused my body to produce large
quantities of histamine. To reduce my histamine level, I had to
eliminate these foods from my diet ?

Histamine Diet
Click on the ?Click Here to see My Diet? Icon to see the actual diet.

Clarinex (desloratadine) is another drug that can reduce
histamine-induced symptoms. ?Desloratadine is an oral, long-acting
antihistamine that is similar chemically to loratadine (Claritin). It
is used to treat the symptoms caused by histamine. Histamine is a
chemical that is responsible for many of the signs and symptoms of
allergic reactions, for example, swelling of the lining of the nose,
sneezing, and itchy eyes. Histamine is released from histamine-storing
cells (mast cells) and then attaches to other cells that have
receptors for histamine. The attachment of the histamine to the
receptors causes the cell to be "activated," releasing other chemicals
which produce the effects that we associate with allergy.?

?Antihistamines suppress the body's release of histamines.
Antihistamines dry up mucus and decrease swelling. But, Antihistamines
can make you drowsy. Also, by drying up the normally moist sinuses,
they can make you more susceptible to infection. Antihistamines may
lose effectiveness after a while. According to experts, it can also
interfere with - and perhaps weaken - the immune system.?

The term ?histadelia? appears to be a contrived word, that appears
nowhere on any reputable medical website or dictionary. I would
exercise caution when interpreting information from sites that utilize
this word, as it appears only on sites that promote books and/or

I urge you to seek medical care if you have an elevated histamine
level, especially if you are considering medications.

 If any part of my answer is unclear, please request an Answer
Clarification and wait for my reply, before rating. This will allow me
to assist you further, if possible.

I wish you the best.
Regards, Crabcakes

Search Terms
Elevated histamine
Cause elevated histamine
Histamine levels
Subject: Re: High Histamine Levels
From: tlspiegel-ga on 07 Feb 2005 23:50 PST
Perhaps the information on this site will be helpful to you:

Always check with your physician or health care provider for medical advice.

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