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Q: Research on sinus and chronic cough ( Answered,   2 Comments )
Subject: Research on sinus and chronic cough
Category: Health
Asked by: miguelineldelbombin-ga
List Price: $50.00
Posted: 26 May 2005 18:45 PDT
Expires: 25 Jun 2005 18:45 PDT
Question ID: 526122
This person has been suffering from sinus and allergies and "DAILY
CHRONIC COUGHING" FOR 7 YEARS. Had surgery and is going to have
surgery again. We would like to find case studies in the medical field
with similar symptons...The coughing is dry, erratic, it happens awake
or sleeping and wake her up. The case study should be medically
proved, in the last 5 years.
Subject: Re: Research on sinus and chronic cough
Answered By: pafalafa-ga on 20 Jun 2005 12:27 PDT

Hello there.

I searched the National Library of Medicine's PubMed database at:

for the terms [ chronic cough dry ].

More than 100 articles were found on this topic.  I've presented the
main ones in my answer, below, where chronic cough seemed to be the
main symptom under investigation.  There were many cases of chronic
dry cough related to various occupational exposures of dust and spores
in the workplace, but I did not include these here, as I imagine this
would have been one of the first possibilities considered by the
patient's doctors.

In addition to citations, I've also included excerpts from the PubMed
abstracts.  I can't post the full abstracts, since they are protected
by copyright, but you can see them yourself by reproducing the search
at the PubMed site.

Note, also, that many of the authors include contact information with
their abstracts, and if available, I've included this information as

I trust the information below fully answers your question.

However, please don't rate this answer until you have everything you
need.  If there's anything more I can do for you, just post a Request
for Clarification, and I'm happy to assist you further.

Best of luck...



Chest. 2005 May;127(5):1714-21

Noneosinophilic CD4 lymphocytic airway inflammation in menopausal
women with chronic dry cough.

Mund E, Christensson B, Gronneberg R, Larsson K.

The National Institute of Environmental Medicine, Division of Lung and
Allergy Research, Karolinska Institutet, SE-171 77, Stockholm, Sweden.

...Chronic dry cough without dyspnea and wheezing is a well-known
condition that is considered to be clinically overrepresented in
women. The etiology and morphology remain unknown in many cases
despite thorough investigations.

...CONCLUSIONS: HLA-DR-activated CD4+ lymphocytic airway inflammation
with a low number of eosinophils was identified in a group of
nonsmoking, nonatopic otherwise healthy women patients with dry cough
of life-long character. The disease appeared exclusively in connection
to menopause.


Lung. 2005;183(1):53-62

The influence of gastroesophageal reflux disease and its treatment on
asthmatic cough.

Bocskei C, Viczian M, Bocskei R, Horvath I.

Koranyi National Institute for TB and Pulmonology, Budapest, Hungary.

...Gastroesophageal reflux is known to cause chronic cough and is also
implicated in worsening of asthma.

...Our data showing that reflux events preceded coughing in most cases
and that treatment of GERD resulted in an improvement in different
outcome measures of asthma suggest that GERD worsens asthma, and its
treatment is of clinical importance to effectively manage these


Lung. 2004;182(5):285-95

A preliminary study of PEFR monitoring in patients with chronic cough.

Sano T, Ueda H, Bando H.

Department of Pulmonary Medicine, Tokushima Prefectural Central
Hospital, Kuramoto-cho 1-10-3, Tokushima, Tokushima 770-8539, Japan.

...It is important to make a differential diagnosis of cough variant
asthma in patients with chronic cough. To examine whether or not peak
expiratory flow rate (PEFR) is useful for the differential diagnosis
of cough variant asthma in such patients, diurnal variation rates of
PEFR were calculated in 23 patients who presented with dry cough
lasting four or more weeks and who showed no abnormalities on chest

...At week 3 of treatment with bronchodilators, only Group 3 showed a
significant decrease in PEFR diurnal variation rate from 25.7% to
10.1%. The cough score decreased significantly in Group 3 only.

Chest. 2005 Feb;127(2):550-7

Cough and glottic-stop reflex sensitivity in health and disease.

Prudon B, Birring SS, Vara DD, Hall AP, Thompson JP, Pavord ID.

MB ChB, Institute for Lung Health, Department of Respiratory Medicine,
Glenfield Hospital, Leicester, LE3 9QP UK

...Little is known about the normal ranges and repeatability of cough
reflex sensitivity measurements, or the relationship of cough reflex
sensitivity to other upper airway reflexes in subjects with chronic
dry cough.

...There was a reasonably close relationship between cough sensitivity
and glottic-stop reflex sensitivity, indicating either that the cough
reflex and the glottic-stop reflex share a common pathway or that
subjects who have a chronic cough have a global abnormality of upper
airway reflexes.

Physiol Res. 2005 Jan 10

Enalapril and diltiazem co-administration and respiratory side effects
of enalapril.

Franova S, Nosalova G, Antosova M.

Department of Pharmacology, Jessenius Faculty of Medicine, Comenius
University, Sklabinska 26, 037 53 Martin, Slovakia.

...Persistent, chronic dry cough is the most common adverse effect of
angiotensin converting enzyme (ACE) inhibitors therapy

...The results showed a partially protective effect of diltiazem and
enalapril coadministration on the respiratory adverse effects induced
by enalapril therapy.

Postgrad Med J. 2004 Jun;80(944):339-45

Clues for the differential diagnosis of hypersensitivity pneumonitis
as an expectant variant of diffuse parenchymal lung disease.

Kupeli E, Karnak D, Kayacan O, Beder S.

Ankara University School of Medicine, Department of Chest Diseases, Ankara, Turkey

...Hypersensitivity pneumonitis, also called extrinsic allergic
alveolitis, a type of diffuse parenchymal lung disease (DPLD), is an
immunologically mediated pulmonary disease induced by inhalation of
various antigens.

...The most common symptoms were dry cough and dyspnoea.

...patients with a history of antigen exposure, with mild symptoms
such as dry cough and dyspnoea, and who have diffuse interstitial lung
involvement on radiology should be carefully evaluated for
hypersensitivity pneumonitis.

Ann Pharmacother. 2003 Nov;37(11):1607-9

Omeprazole-induced intractable cough.

Howaizi M, Delafosse C.

Gastroenterology and Hepatology Department, Simone Veil Hospital,
Eaubonne, France.

...OBJECTIVE: To report a case of chronic, persistent cough induced by
omeprazole therapy

...CONCLUSIONS: Chronic, persistent cough may occur as an adverse
effect of omeprazole therapy. Clinicians must be aware of this adverse
effect to avoid useless and costly tests.

Zhonghua Jie He He Hu Xi Za Zhi. 2003 Jun;26(6):362-5

Clinical feature and airway inflammation in eosinophilic bronchitis

Ma HM, Zhu LX, Lai KF, Zhu T, Sun BQ, Zhong NS.

Guangzhou Institute of Respiratory Disease, Guangzhou 510120, China.

...Irwin's anatomic protocol for diagnosing chronic cough was used in
86 patients with chronic cough, and induced sputum by hypertonic
saline aerosol inhalation was performed.

...CONCLUSION: EB, an eosinophilic airway inflammation, is one of
important causes of chronic cough and responds well to corticosteroid

Pediatr Pulmonol. 2003 Jul;36(1):73-5.

Psychogenic cough in a schoolboy: evaluation using an ambulatory cough recorder.

McGarvey LP, Warke TJ, McNiff C, Heaney LG, MacMahon J.

Department of Respiratory Medicine, Belfast City Hospital, Northern
Ireland, UK.

...Psychogenic cough occurs most commonly in patients under 18 years of age

...A large number of cough episodes were recorded during the day, but
during the time he was in bed there were very few episodes recorded.
This suggested a diagnosis of psychogenic cough, and he underwent
behavior modification therapy under the guidance of a clinical
psychologist, with good result.

...Objective cough monitoring may therefore improve the evaluation and
management of chronic cough.

J Korean Med Sci. 2002 Oct;17(5):616-20

Cough sensitivity and extrathoracic airway responsiveness to inhaled
capsaicin in chronic cough patients.

Cho YS, Lee CK, Yoo B, Moon HB.

Division of Allergy and Rheumatology, Department of Medicine, Asan
Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

...Enhanced cough response has been frequently observed in chronic cough. 

...results indicate that cough sensitivity is closely related with
extrathoracic airway responsiveness during capsaicin provocation in
some chronic cough patients.

Eur Respir J. 2002 Mar;19(3):479-86

Associations between markers of respiratory morbidity in European children.

Timonen KL, Schwartz J, Nielsen J, Brunekreef B.

Unit of Environmental Epidemiology, National Public Health Institute.
Kuopio, Finland

...In a multicentre European study, the association between chronic
respiratory symptoms (reported in a questionnaire), skin-prick test
results, and lung function, and the occurrence of acute respiratory
morbidity, was examined among children aged 6-12 yrs with chronic
respiratory symptoms

...asthmatic symptoms reported in a questionnaire, atopic status and a
reduced level of maximal mid-expiratory flow were associated with the
occurrence of acute respiratory symptoms, especially those of lower
respiratory symptoms.

Schweiz Med Wochenschr. 2000 Dec 23;130(51-52):2001-8.

Rapidly progressing respiratory insufficiency of uncertain etiology

Bingisser RM, Gutmann M, Dalquen P.

.....In a 59-year-old male patient, chronic dry cough and dyspnoea on
exertion preexisting for several years became rapidly progressive
within a few weeks prior to hospitalisation.

.....The search for pneumonia, viral infection, tumour, vasculitis, or
a drug-related disorder remained negative. Pathological examination at
autopsy showed nonuniform fibrosing alveolitis.

J Med. 2001;32(3-4):181-7

The combined cough frequency/severity scoring: a new approach to cough
evaluation in clinical settings.

Fisman EZ, Shapira I, Motro M, Pines A, Tenenbaum A.

Cardiac Rehabilitation Institute, Chaim Sheba Medical Center Tel Hashomer, Israel.

...The present study was aimed to determine the feasibility of a new
combined frequency/severity cough scoring method in patients with
ACE-I induced cough before and after their modification with aspirin

....The new combined cough frequency/severity scoring is suitable for
clinical practice and can improve the identification of dynamic cough
modifications during treatment period as compared with the
conventional frequency score method. It may have important
implications in the evaluation of patients with respiratory and
cardiovascular disorders.

Pneumologie. 2001 May;55(5):249-52

Eosinophilic bronchitis without asthma--an additional rare cause for
chronic persistent cough (CPC)? A 30-year old patient with severe CPC
due to eosinophilic bronchitis without asthma or hyperreactivity

Kardos P.

Gemeinschaftspraxis und Pneumologisches-allergologisches Zentrum,
Maingau Krankenhaus, Frankfurt a.M.

...In non-smokers the underlying causes for chronic persistent cough
(CPC) e.g. chronic cough without diagnostic chest X-ray or pulmonary
function test--are usually as follows: several common upper airways
diseases, bronchial (cough type) asthma, gastrooesophageal reflux or
treatment with an ACE (angiotensin converting enzyme)--inhibitor. In
10% of CPC however the cause remains uncertain.

...(Induced) sputum staining should be added to the diagnostic
armamentarium of CPC.

Thorax. 2001 Jun;56(6):450-5

Sex dependent differences in physiological ageing in the immune system
of lower airways in healthy non-smoking volunteers: study of
lymphocyte subsets in bronchoalveolar lavage fluid and blood.

Mund E, Christensson B, Larsson K, Gronneberg R.

Division of Respiratory Medicine and Allergology, Department of
Medicine, Karolinska Institutet at Huddinge University Hospital, S-141
86 Huddinge, Sweden.

...Age related changes in the immune system have been studied
frequently but a possible relation to sex has not, to our knowledge,
previously been examined.

...The composition of lymphocytes with different phenotypes in the
lower respiratory tract changes with age in women but not in men. This
may have implications for some clinical conditions such as chronic dry
cough which are observed predominantly in women.

Folia Med Cracov. 2000;41(3-4):25-33

Population based studies on the incidence of chronic respiratory
symptoms and lung function in children from Krakow

Jedrychowski W, Flak E, Mroz E.

Katedra Epidemiologii i Medycyny Zapobiegawczej Collegium Medicum UJ
31-034 Krakow, ul. Kopernika 7

...The epidemiologic study has been carried out in the sample of 1048
schoolchildren at the age of 11 years in order to assess the impact of
various chronic respiratory symptoms on lung function

...only chronic dry cough was related significantly to the lower
values of FEV1 and PEFR in the children

Adv Perit Dial. 2000;16:129-33

Prevalence and causes of cough in chronic dialysis patients: a
comparison between hemodialysis and peritoneal dialysis patients.

Min F, Tarlo SM, Bargman J, Poonai N, Richardson R, Oreopoulos D.

University Health Network, Toronto, Ontario, Canada

...Peritoneal dialysis (PD) and hemodialysis (HD) are both common
forms of dialysis for patients with end-stage renal disease. A few
case reports have suggested that cough is associated with PD

...The findings suggest that GERD and associated cough are more common
in PD patients than in HD patients, perhaps owing to increases in
intra-abdominal pressure from the peritoneal dialysate.

Arch Bronconeumol. 2000 Jul-Aug;36(7):385-90

Rhinitis and cough syndrome. Are epidemiologic, clinical and
functional characteristics useful in the differential diagnosis with
bronchial asthma?]

Elias Hernandez MT, Sanchez Gil R, Castillo Gomez J.

Unidad Medico-Quirurgica de Enfermedades Respiratorias, Hospital
Universitario Virgen del Rocio, Sevilla.

...Patients often visit family practitioners or respiratory
specialists complaining of cough. In non-smokers, the most common
cause is postnasal drip secondary to rhinitis

...CONCLUSIONS: 1) Rhinitis was the most common cause of chronic cough
in the studied patients in whom a diagnosis of bronchial asthma had
been suspected

Thorax. 1999 Mar;54(3):234-7

Increased neutrophils and cytokines, TNF-alpha and IL-8, in induced
sputum of non-asthmatic patients with chronic dry cough.

Jatakanon A, Lalloo UG, Lim S, Chung KF, Barnes PJ.

Department of Thoracic Medicine, Imperial College School of Medicine, London, UK

...The pathogenesis of non-asthmatic chronic dry cough remains unclear

...Neutrophils and cytokines associated with neutrophil chemotaxis and
activation may contribute to the pathogenesis of non-asthmatic chronic
dry cough.


Again, let me know if there is anything else I can do for you on this.

Subject: Re: Research on sinus and chronic cough
From: p1212-ga on 26 May 2005 21:10 PDT
Believe it or not, lactose intolerance can cause chronic sinus issues.
 I've heard of cases of individuals who have removed dairy from their
diet and their sinus issues have cleared.  Have you tried removing
dairy from the diet?
Subject: Re: Research on sinus and chronic cough
From: standsbyriver-ga on 05 Jun 2005 17:47 PDT
I had the same cough you describe for years and found out I had
esphogeal reflux. I stopped Ice tea and rich foods late in the day,
and sleep slighly elevated. My cough stopped. Apparently the tiniest
bit of acid reflux can trigger a cough, even when you are not aware
you are having it.

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