"Way Down in the Hole" was written by Tom Waits. Here you can listen
to an audio clip from the cover version as performed by Clarence
Fountain and The Blind Boys of Alabama:
Here's some documentation:
"The Blind Boys Of Alabama's 'Way Down In The Hole' Is Theme For HBO's
'The Wire' ...The riveting drama series depicts a world where
distinctions between good & evil and crime & punishment are blurred.
The show premiered June 2nd at 10pm."
The Rosebud Agency
"The Blind Boys of Alabama's song 'Way Down in the Hole' from their
Grammy award winning album Spirit of the Century is the main title
theme song for HBOs new series, The Wire, which premiered June 2,
Blues Music Association
Here is the Blind Boys' home page, with a wealth of information about
Episode guides, message boards, and more information about "The Wire"
can be found at HBO's site:
HBO: The Wire
Google search strategy:
"hbo" + "wire" + "way down in the hole"
"blind boys of alabama"
I hope you're not feeling "clueless" any more! If any part of my
answer is unclear, or if links are broken, please ask for