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Q: Bioadhesives ( Answered 4 out of 5 stars,   0 Comments )
Subject: Bioadhesives
Category: Science > Chemistry
Asked by: blucken-ga
List Price: $200.00
Posted: 20 Apr 2006 06:20 PDT
Expires: 20 May 2006 06:20 PDT
Question ID: 720933
I would like to know...

- What are the different products that qualify as bioadhesives?

For these products:

- What is the actual adhesive?  What is it made up of?  How is it made?

- Who (supplier) makes it?  Is it branded?  What is the brand?  Is it

- What differentiates the adhesive from another bioadhesive?  What does it do?

Thank you!!
Subject: Re: Bioadhesives
Answered By: czh-ga on 20 Apr 2006 16:32 PDT
Rated:4 out of 5 stars
Hello blucken-ga,

My research shows that there is a lot of information available about
bioadhesives and all of the questions you?ve asked. These adhesives
are used in transdermal drug delivery systems and this is considered
to be a mature industry by some while others argue that there are a
lot of opportunities for niche markets.

I?ve collected a variety of articles to address your questions but I
wasn?t sure about what were your chief areas of interest so I?ve
included both scientific and marketing papers and reports and I didn?t
attempt to summarize the scientific material. I suggest that you
review what I?ve posted. Please clarify what additional information
you need if I?ve failed to cover some points of interest.

Wishing you well for your projects.

~ czh ~

What are the different products that qualify as bioadhesives?
 -- What differentiates the adhesive from another bioadhesive?  
 -- What does it do?
Published in: Encyclopedia of Biomaterials and Biomedical Engineering
For online pricing and information on special print/online bundling
discounts, please call 1-888-318-2367 OR email:
Author: John D. Smart 
Pages: 62 - 71 
DOI: 10.1081/E-EBBE-120007260 
Published on: 31/Aug/2004 
Electronic ISBN 

Many examples of bioadhesion exist in nature, including such diverse
events as cell-to-cell adhesion within a living tissue, barnacles
binding to rocks, and bacteria binding to tooth enamel. In health
care, bioadhesives were first used as wound dressings, skin adhesives,
and denture fixatives. Over the last two decades, bioadhesives have
been of interest within the pharmaceutical sciences for their
potential to optimize drug delivery. Such drug delivery may be
optimized at the site of action (e.g., on the cornea or within the
oral cavity) or at the absorption site (e.g., in the small intestine
or nasal cavity). Bioadhesives may also be used as therapeutic agents
in their own right, to coat and protect damaged tissues (gastric
ulcers or lesions of the oral mucosa) or to act as lubricating agents
(in the oral cavity, eye, and vagina). Skin adhesives, tissue
sealants, and dental and bone adhesives and cements are also defined
as bioadhesives.

This article first focuses on the types of muco/bioadhesives currently
used in the pharmaceutical sciences, from first-generation hydrophilic
polymers to second-generation polymers and lectins. The nature of
bioadhesive interactions, types of bioadhesive formulations developed,
and regions of the human body to which they may be administered are
also considered.

Other types of medical bioadhesives, such as those used in wound
management, surgery, and dentistry, are also discussed.

Keyword(s): Skin adhesives ; Bone cements ; Tissue adhesives ;
Chitosan ; Poly(acrylic acid) ; Carbomer ; Mucoadhesion ; Bioadhesive
; Bioadhesion ; Orthodontic adhesives

How do I request a free trial to an Encyclopedia title? 
For institutions in North and South America, please email or call 1-800-797-3803 x7119.

(A section preview is available if you register and you can read three
sections of the article. I registered and read the previews for
Introduction, Pharmaceutical Bioadhesives and Conclusion. I believe
this article may answer all of your questions regarding the
definitions and types of adhesives, their manufacturing and production
and the technical challenges in the field. The section on
Pharmaceutical Bioadhesives included the chemical names and formulas
of the materials discussed. The article doesn?t seem to have any
information about branding or commercialization.

I suggest that you register and read the previews in sections 2 and 3.
This will give you sufficient information to decide whether a
subscription will be appropriate for you so that you can read the
entire article and in order to access other topics in this

Table of Contents
	1. Introduction preview 
	2. Pharmaceutical Bioadhesives preview 
		2.1. First-Generation Bioadhesives 
		2.2. The Bioadhesive Bond 
		2.3. Multifunctional Bioadhesives 
		2.4. Second-Generation Bioadhesives 
		2.5. Formulation Factors 
		2.6. Routes of Administration 
	3. Medical Bioadhesives preview 	
		3.1. Skin Adhesives 
		3.2. Tissue Sealants 
		3.3. Dental Adhesives and Cements 
		3.4. Bone Cements and Bone Graft Substitutes 
		3.5. Other Adhesives 
	4. Conclusion preview 	
	5. Articles of Further Interest preview 	
	6. References no preview	

Drugs and the Pharmaceutical Sciences 
#98: Bioadhesive Drug Delivery Systems

This invaluable reference presents a comprehensive review of the basic
methods for characterizing bioadhesive materials and improving vehicle
targeting and uptake-offering possibilities for reformulating existing
compounds to create new pharmaceuticals at lower development costs.
Evaluates the unique carrier characteristics of bioadhesive polymers
and their power to enhance localization of delivered agents, local
bioavailability, and drug absorption and transport!

-- What is the actual adhesive?  
 -- What is it made up of?
Transdermal Drug Delivery Systems : A Review 
Thursday, 12 January 2006

(This is a long and comprehensive article that addresses your
questions. It includes chemical descriptions and formulas.)

Poly(amino acid) bioadhesives for tissue repair 
Source: Journal of Biomaterials Science, Polymer Edition
Volume 11, Number 10, 2000, pp. 1023-1038(16)
The full text article is available for purchase $25.00 plus tax

We report here on poly(amino acid)-based bioadhesives with potential
to bond to soft tissues. The systems investigated included homopolymer
poly(amino acids), mixtures of poly(amino acids) and amino acids, and
blends of different poly(amino acids). Adhesive performance was tested
in tension on glass surfaces, chondroitin sulfate surfaces, as well as
bovine cartilage surfaces. The amino acid structural units contained
acidic, basic, or polar side chains and were found to adhere
reasonably well to the surfaces of glass and chondroitin sulfate.

4 Myths About Transdermal Drug Delivery

An area of continued interest is the transdermal patch formulation.
Because drug-in-adhesive technology has become the preferred system
for passive transdermal delivery, two areas of formulation research
are focused on adhesives and excipients. Adhesive research focuses on
customizing the adhesive to improve skin adhesion over the wear
period, improve drug stability and solubility, reduce lag time, and
increase the rate of delivery.18-21 Because a one-size-fits-all
adhesive does not exist that can accommodate all drug and formulation
chemistries, customizing the adhesive chemistry allows the transdermal
formulator to optimize the performance of the transdermal patch.19-21

(This is a long and detailed article with an extensive bibliography
that discusses the state of the transdermal drug delivery industry and
addresses many issue relating to bioadhesives.

articles searching on adhesives
8 items found

What Is A Bioadhesive?
November 1, 2005 

A number of adhesives and sealants are suitable for short- and/or
long-term biomedical applications. Typical adhesives used in medical
products include silicones, epoxies, acrylics and polyurethanes.
Perhaps the most interesting materials, however, are those that are
aimed at surgical applications.

Middle East Technical University
Biomaterials Research Group
Biomaterials course term-paper database

Adhesives by Oya Tagit
Bone cements by Ceren Oktar
Bone cements by I??l Severcan
Fibrin glue by Didem Demirba?

Some of the term papers give basic description of various aspects of
biomaterials and bioadhesion is simple and language.

 -- How is it made?
 -- Who (supplier) makes it?  
 -- Is it branded?  
 -- What is the brand?  
 -- Is it commercialized?
Mar 30, 2005 
Exactly what is a Bioadhesive?

Biomaterials are becoming valuable resources both commercially and in
extending the functionality of our aging bodies. This week's editorial
takes a look at the significant promise of several new bioadhesives
and biosealants.

(Products mentioned: Dermabond and Liquid Band-Aid manufactured by
Closure, a small start-up company located in Raleigh, NC that was
recently acquired by Johnson and Johnson.)

Adhesives in Transdermal Drug Delivery Systems: Sticking it to Them
Since 1979  Date Published: 31 Oct 2005

As traditional applications for pressure sensitive adhesives begin to
mature, manufacturers are beginning to explore niche markets to enter
and grow their business.  In some cases, niche applications are
high-tech and require development of new adhesives. These adhesives
command a greater price and can result in large streams of revenue for
adhesive manufacturer. The growth from such applications is further
compounded if the products they are used in exhibit a high growth
rate.  One such area is transdermal drug delivery.*   Many, but not
all, transdermal drug delivery (TDD) systems require the use of
adhesives, and current TDD technology advances suggest a bright future
for this segment of the medical market.

(This article provides a lot of information about the development of
the TDD and associated bioadhesive market since 1979. Market trends
and specific products are discussed.)

Transdermal Drug Delivery

Reservoir/Membrane Versus Matrix Transdermal Patches  
The second type of traditional transdermal patch is the matrix system.
The active drug in this type of patch is contained in a polymer
matrix. The drug is released at a rate governed by the components in
the matrix. In a matrix patch, the drug, adhesive, and polymer matrix
are combined.

Currently Marketed Transdermal Drug Delivery Systems 
There are currently a small number of drug products available as
transdermal dosage forms. The 20 transdermal patches described in
TABLE 1 are based on only eight drug molecules. Of the 20 patches, 12
are the matrix type and eight are the membrane type.

(This is a long article that provides a good description of the
application of bioadhesives in TDD. The table provides brand names.)

Your Search for 'drug delivery' returned 186 results 

Kollodis BioSciences, Inc. (KBS) is a biotech company focused on the
commercialization of a proprietary recombinant protein adhesive

Q: List of companies into the transdermal drug delivery business


bioadhesive materials
bioadhesives classification OR categories OR definition OR specification OR types
Adhesives Transdermal Drug Delivery
bioadhesive market OR industry
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